Gene Report

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Basic Info

Approved Symbol	TPX2
Previous Symbol	C20orf2, C20orf1
Symbol Alias	p100, DIL-2
Approved Name	TPX2, microtubule-associated
Previous Name	chromosome 20 open reading frame 1, "TPX2, microtubule-associated, homolog (Xenopus laevis)"
Location	20q11.2
Position	chr20:31739271-31801805, 1
External Links	HGNC: 1249 Entrez Gene: 22974 Ensembl: ENSG00000088325 UCSC: uc002wwp.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.06. Encodes form TPX2 protein that is required for normal assembly of microtubules during apoptosis.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	TAS[9207457]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060236	regulation of mitotic spindle organization	biological process	ISS[18663142]	1
GO:0000922	spindle pole	cellular component	IDA[14718566]	6
GO:0051301	cell division	biological process	IEA	20
GO:0015630	microtubule cytoskeleton	cellular component	IDA	12
GO:0005819	spindle	cellular component	ISS[18663142]	9
GO:0005874	microtubule	cellular component	IEA	24
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005515	protein binding	molecular function	IPI[14580337]	563
GO:0005524	ATP binding	molecular function	TAS[10512675]	118
GO:0032147	activation of protein kinase activity	biological process	IDA[14580337]	4
GO:0007067	mitotic nuclear division	biological process	IEA	15
GO:0008283	cell proliferation	biological process	TAS[10512675]	37
GO:0005525	GTP binding	molecular function	TAS[10512675]	20
GO:0043203	axon hillock	cellular component	IEA	3
GO:0019901	protein kinase binding	molecular function	IPI[14580337]	29
GO:0006915	apoptotic process	biological process	IEA	39

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
ranMSpathway	Role of Ran in mitotic spindle regulation	1

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TPX2	AURKA	NO	in vitro;in vivo	12177045 , 14580337
TPX2	HMMR	NO	in vivo	15705883

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:31739271..31801805 View in gBrowse