Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	CLIP1
Previous Symbol	RSN
Symbol Alias	CYLN1, CLIP170, CLIP, CLIP-170
Approved Name	CAP-GLY domain containing linker protein 1
Previous Name	restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Name Alias	restin
Location	12q24.3
Position	chr12:122271432-122422632, -1
External Links	HGNC: 10461 Entrez Gene: 6249 Ensembl: ENSG00000130779 UCSC: uc001ucg.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shink, E.,2005(a)	Other variant: RSN_GC04E12A, RSN_GC04E14A, RSN_GC04E19A	We found no polymorphisms associated with bipolar disorder in this gene.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 26)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003676	nucleic acid binding	molecular function	IEA	5

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005813	centrosome	cellular component	IDA[21399614]	34
GO:0046872	metal ion binding	molecular function	NAS[15928712]	115
GO:0031116	positive regulation of microtubule polymerization	biological process	IMP[15262990]	1
GO:0015630	microtubule cytoskeleton	cellular component	IMP[17889670]	12
GO:0035371	microtubule plus-end	cellular component	IDA; IDA[12433698]	2
GO:0005874	microtubule	cellular component	IMP[19004523]; ISS	24
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0044861	protein transport into plasma membrane raft	biological process	IEA	1
GO:0001578	microtubule bundle formation	biological process	IMP[17889670]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0008270	zinc ion binding	molecular function	IDA[17828275]	77
GO:0008017	microtubule binding	molecular function	IDA[17889670]	10
GO:0007067	mitotic nuclear division	biological process	TAS[15928712]	15
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0005881	cytoplasmic microtubule	cellular component	IEA	2
GO:0005882	intermediate filament	cellular component	TAS[1600942]	8
GO:0051010	microtubule plus-end binding	molecular function	IDA[12433698]	2
GO:0005768	endosome	cellular component	TAS[1356075]	27
GO:0042803	protein homodimerization activity	molecular function	TAS[15928712]	71
GO:0015631	tubulin binding	molecular function	IDA[17889670]	5
GO:0001726	ruffle	cellular component	IEA	10
GO:0044354	macropinosome	cellular component	IDA[12433698]	1
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA	12
GO:0005515	protein binding	molecular function	IPI[11940666]	563
GO:0000776	kinetochore	cellular component	TAS[15928712]	7

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CLIP1	MAPRE2	NO	in vitro	16455083
CLIP1	IQGAP1	NO	in vitro;in vivo	12110184
CLIP1	CLASP2	NO	in vitro;yeast 2-hybrid	11290329
CLIP1	PAFAH1B1	NO	in vitro;in vivo;yeast 2-hybrid	11940666
CLIP1	DCTN1	NO	in vivo	12789661

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Variant Name	Variant Type	No. of Studies (Positive/Negative/Trend)
RSN_GC04E19A	point mutation	1 (0/1/0)
RSN_GC04E14A	point mutation	1 (0/1/0)
RSN_GC04E12A	point mutation	1 (0/1/0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
12q24.3	chr12:120300000-133275309	1 (1/0/0)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q24	chr12:108600000-133275309	4 (1/1/2)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q24.31	chr12:120300000-125400000	1 (1/0/0)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr12:122271432..122422632 View in gBrowse