Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	KAT6B
Previous Symbol	MYST4
Symbol Alias	querkopf, qkf, Morf, MOZ2, ZC2HC6B
Approved Name	K(lysine) acetyltransferase 6B
Previous Name	MYST histone acetyltransferase (monocytic leukemia) 4
Name Alias	MOZ-related factor
Location	10q22.2
Position	chr10:74825582-75032622, 1
External Links	HGNC: 17582 Entrez Gene: 23522 Ensembl: ENSG00000156650 UCSC: uc001jwn.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kuo, P. H., 2014	SNP: rs11001178, rs16931793	Gene-based P-value (allelic model) =0.0078, P-value (additive model) =0.0047. MYST4, which encodes histone acetyltransferase (P = 0.0047)	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA; TAS[10497217]	283
GO:0003677	DNA binding	molecular function	IEA	83

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004402	histone acetyltransferase activity	molecular function	IDA[10497217]	5
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[10497217]	58
GO:0016573	histone acetylation	biological process	IDA[11965546]	5
GO:0016407	acetyltransferase activity	molecular function	IDA[11965546]	2
GO:0008134	transcription factor binding	molecular function	IDA[11965546]	28
GO:0006355	regulation of transcription, DNA-templated	biological process	NAS[10497217]	62
GO:0005515	protein binding	molecular function	IPI[11965546]	563
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0070776	MOZ/MORF histone acetyltransferase complex	cellular component	IDA[16387653]	2
GO:0006334	nucleosome assembly	biological process	NAS[10497217]	2
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0043966	histone H3 acetylation	biological process	IDA[16387653]	4
GO:0000786	nucleosome	cellular component	NAS[10497217]	1
GO:0006325	chromatin organization	biological process	TAS	14
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[10497217]	43
GO:0005654	nucleoplasm	cellular component	TAS	163

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 44)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11001178	chrCHR_HG2191_PATCH:74844104 - 74844104(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs7917746	chrCHR_HG2191_PATCH:74907902 - 74907902(1)	intron_variant	1(1/0/0)
rs16931793	chrCHR_HG2191_PATCH:74875963 - 74875963(1)	intron_variant	1(1/0/0)
rs7909358	chrCHR_HG2191_PATCH:74930381 - 74930381(1)	intron_variant	1(1/0/0)

LD-proxies (count: 40)

rs_ID	Location	Functional Annotation
rs2278803	chrCHR_HG2191_PATCH:74978999 - 74978999(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs3213967	chrCHR_HG2191_PATCH:74971931 - 74971931(1)	intron_variant
rs1868628	chrCHR_HG2191_PATCH:75002892 - 75002892(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs2278804	chrCHR_HG2191_PATCH:74991538 - 74991538(1)	intron_variant; non_coding_transcript_variant
rs2395125	chrCHR_HG2191_PATCH:74941272 - 74941272(1)	intron_variant
rs2395124	chrCHR_HG2191_PATCH:74932896 - 74932896(1)	intron_variant
rs10824251	chrCHR_HG2191_PATCH:74966224 - 74966224(1)	intron_variant
rs7072392	chrCHR_HG2191_PATCH:74945351 - 74945351(1)	intron_variant
rs736086	chrCHR_HG2191_PATCH:74926084 - 74926084(1)	intron_variant
rs7097121	chrCHR_HG2191_PATCH:74920947 - 74920947(1)	intron_variant
rs12260609	chrCHR_HG2191_PATCH:74896880 - 74896880(1)	intron_variant
rs4746248	chrCHR_HG2191_PATCH:74948180 - 74948180(1)	intron_variant
rs1993006	chrCHR_HG2191_PATCH:74946286 - 74946286(1)	intron_variant
rs1551067	chrCHR_HG2191_PATCH:75029427 - 75029427(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs10762649	chrCHR_HG2191_PATCH:74952096 - 74952096(1)	intron_variant
rs4746250	chrCHR_HG2191_PATCH:75010731 - 75010731(1)	intron_variant; non_coding_transcript_variant
rs10824242	chrCHR_HG2191_PATCH:74885296 - 74885296(1)	intron_variant
rs11001252	chrCHR_HG2191_PATCH:75036856 - 75036856(1)	downstream_gene_variant
rs958320	chrCHR_HG2191_PATCH:74852808 - 74852808(1)	intron_variant
rs1880690	chrCHR_HG2191_PATCH:74906981 - 74906981(1)	intron_variant
rs11001179	chrCHR_HG2191_PATCH:74845781 - 74845781(1)	downstream_gene_variant; intron_variant
rs4745760	chrCHR_HG2191_PATCH:74900629 - 74900629(1)	intron_variant
rs6480762	chrCHR_HG2191_PATCH:74870534 - 74870534(1)	intron_variant
rs7092435	chrCHR_HG2191_PATCH:74912610 - 74912610(1)	intron_variant
rs951308	chrCHR_HG2191_PATCH:74859778 - 74859778(1)	intron_variant
rs10824245	chrCHR_HG2191_PATCH:74909098 - 74909098(1)	intron_variant
rs7072471	chrCHR_HG2191_PATCH:74915505 - 74915505(1)	intron_variant
rs2395121	chrCHR_HG2191_PATCH:74913148 - 74913148(1)	intron_variant
rs7906881	chrCHR_HG2191_PATCH:74843666 - 74843666(1)	intron_variant; non_coding_transcript_variant
rs4746247	chrCHR_HG2191_PATCH:74924866 - 74924866(1)	intron_variant
rs6480764	chrCHR_HG2191_PATCH:74915761 - 74915761(1)	intron_variant
rs10824244	chrCHR_HG2191_PATCH:74889274 - 74889274(1)	intron_variant
rs11001187	chrCHR_HG2191_PATCH:74867956 - 74867956(1)	intron_variant
rs11001184	chrCHR_HG2191_PATCH:74854052 - 74854052(1)	intron_variant
rs7095910	chrCHR_HG2191_PATCH:74896019 - 74896019(1)	intron_variant
rs7899542	chrCHR_HG2191_PATCH:74911016 - 74911016(1)	intron_variant
rs12221332	chrCHR_HG2191_PATCH:74893241 - 74893241(1)	intron_variant
rs16931798	chrCHR_HG2191_PATCH:74883661 - 74883661(1)	intron_variant
rs7917040	chrCHR_HG2191_PATCH:74879678 - 74879678(1)	intron_variant
rs12220684	chrCHR_HG2191_PATCH:74871010 - 74871010(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q22	chr10:68800000-80300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr10:74825582..75032622 View in gBrowse