Gene Report

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Basic Info

Approved Symbol	RABGAP1L
Symbol Alias	HHL, TBC1D18, KIAA0471, FLJ38519
Approved Name	RAB GTPase activating protein 1-like
Location	1q24
Position	chr1:174159410-174995308, 1
External Links	HGNC: 24663 Entrez Gene: 9910 Ensembl: ENSG00000152061 UCSC: uc001gjx.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs989423	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[16923123]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043547	positive regulation of GTPase activity	biological process	IDA[16923123]; IEA	30
GO:0032880	regulation of protein localization	biological process	IDA[16923123]	4
GO:0005794	Golgi apparatus	cellular component	IDA[16923123]	60
GO:0017137	Rab GTPase binding	molecular function	IDA[16923123]	6
GO:0005096	GTPase activator activity	molecular function	IDA[16923123]	19
GO:0005769	early endosome	cellular component	IDA[16923123]	13

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6681627	chr1:174157604 - 174157604(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs989423	chr1:174813385 - 174813385(1)	intron_variant; NMD_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1q24.2-q25.1	chr1:167200000-176100000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:174159410..174995308 View in gBrowse