Gene Report

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Basic Info

Approved Symbol	TSPYL4
Symbol Alias	dJ486I3.2, KIAA0721
Approved Name	TSPY-like 4
Location	6q22.1
Position	chr6:116249961-116254140, -1
External Links	HGNC: 21559 Entrez Gene: 23270 Ensembl: ENSG00000187189 UCSC: uc003pwn.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010		For gene-based test, P-value = 0.041 in STEP1. nominally significant in STEP1 sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006334	nucleosome assembly	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TSPYL4	CELSR3	NO	yeast 2-hybrid	12421765
TSPYL4	CCDC85B	NO	yeast 2-hybrid	16189514
TSPYL4	NINL	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 8)

rs_ID	Location	Functional Annotation
rs2232472	chr6:116253292 - 116253292(1)	downstream_gene_variant; synonymous_variant; upstream_gene_variant
rs9387389	chr6:116252504 - 116252504(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs1931895	chr6:116251808 - 116251808(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs1048920	chr6:116245042 - 116245042(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs3749893	chr6:116250532 - 116250532(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs6755	chr6:116250092 - 116250092(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs1055814	chr6:116249434 - 116249434(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs1052443	chr6:116247610 - 116247610(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:116249961..116254140 View in gBrowse