Gene Report

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Basic Info

Approved Symbol	ZNF536
Symbol Alias	KIAA0390
Approved Name	zinc finger protein 536
Location	19q13.11
Position	chr19:30228290-30713538, 1
External Links	HGNC: 29025 Entrez Gene: 9745 Ensembl: ENSG00000198597 UCSC: uc002nsu.1
No. of Studies	2 (Positive: 0; Negative: 1; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Winham S.J., 2014	SNP: rs7249968	rs7249968 near ZNF536 showed little evidence for association with BD.	Trend	Comment on Study
Xu, W., 2014	SNP: rs12609580, rs12610463, rs2866972, rs4805573, rs4805574	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044323	retinoic acid-responsive element binding	molecular function	IEA	1
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[19398580]	23
GO:0048387	negative regulation of retinoic acid receptor signaling pathway	biological process	IEA	1
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA[19398580]	14
GO:0045665	negative regulation of neuron differentiation	biological process	IEA	8
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[19398580]	62
GO:0046872	metal ion binding	molecular function	IEA	115

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 18)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4805573	chr19:30504848 - 30504848(1)	intron_variant	1(0/1/0)
rs7249968	chr19:30220335 - 30220335(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)
rs2866972	chr19:30482476 - 30482476(1)	intron_variant	1(0/1/0)
rs4805574	chr19:30522854 - 30522854(1)	intron_variant	1(0/1/0)
rs12610463	chr19:30489060 - 30489060(1)	intron_variant	1(0/1/0)
rs12609580	chr19:30529495 - 30529495(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs3786796	chr19:30514027 - 30514027(1)	intron_variant
rs2866971	chr19:30482055 - 30482055(1)	intron_variant
rs3786792	chr19:30535636 - 30535636(1)	intron_variant
rs12611123	chr19:30508596 - 30508596(1)	intron_variant
rs3786797	chr19:30513054 - 30513054(1)	intron_variant
rs11879284	chr19:30503749 - 30503749(1)	intron_variant
rs11880513	chr19:30505082 - 30505082(1)	intron_variant
rs4804932	chr19:30487575 - 30487575(1)	intron_variant
rs4804934	chr19:30504718 - 30504718(1)	intron_variant
rs12609450	chr19:30529111 - 30529111(1)	intron_variant
rs2082484	chr19:30530200 - 30530200(1)	intron_variant
rs3786794	chr19:30532912 - 30532912(1)	intron_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lyudmila Georgieva[2014]_13	chr19:30861683-36685690 (UCSC build 37, hg19)	58247	19q12-q13.12	duplication

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr19:30228290..30713538 View in gBrowse