Gene Report

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Basic Info

Approved Symbol	BRE
Symbol Alias	BRCC45, BRCC4
Approved Name	brain and reproductive organ-expressed (TNFRSF1A modulator)
Name Alias	BRCA1/BRCA2-containing complex, subunit 4
Location	2p23
Position	chr2:27889941-28338901, 1
External Links	HGNC: 1106 Entrez Gene: 9577 Ensembl: ENSG00000158019 UCSC: uc002rls.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cichon, S.,2011	SNP: rs6547829	No positive signal in this gene was observed for BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[15465831]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006974	cellular response to DNA damage stimulus	biological process	IEP[7826398]	14
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0000152	nuclear ubiquitin ligase complex	cellular component	IDA[14636569]	1
GO:0006302	double-strand break repair	biological process	IMP[19261748]	6
GO:0070552	BRISC complex	cellular component	IDA[19214193]	1
GO:0031593	polyubiquitin binding	molecular function	IDA[19261749]	3
GO:0016568	chromatin modification	biological process	IEA	5
GO:0000268	peroxisome targeting sequence binding	molecular function	TAS[11676476]	1
GO:0006915	apoptotic process	biological process	IEA	39
GO:0005515	protein binding	molecular function	IPI[14636569]	563
GO:0005164	tumor necrosis factor receptor binding	molecular function	IDA[15465831]	2
GO:0045739	positive regulation of DNA repair	biological process	IMP[19261748]	4
GO:0007165	signal transduction	biological process	TAS[9737713]	136
GO:0010212	response to ionizing radiation	biological process	IMP[19261748]	2
GO:0031572	G2 DNA damage checkpoint	biological process	IMP[19261748]	2
GO:0070531	BRCA1-A complex	cellular component	IDA[17525341]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
BRE	C19orf62	NO	yeast 2-hybrid	16189514
BRE	GFI1B	YES	yeast 2-hybrid	16713569

Related other genetic factors

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6547829	chr2:28101002 - 28101002(1)	intron_variant	1(0/1/0)
rs13414801	chr2:28067480 - 28067480(1)	intron_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs11889865	chr2:28122922 - 28122922(1)	intron_variant
rs10495762	chr2:28117981 - 28117981(1)	intron_variant
rs937813	chr2:28078673 - 28078673(1)	intron_variant
rs7602555	chr2:28185795 - 28185795(1)	intron_variant
rs6710247	chr2:28189691 - 28189691(1)	intron_variant
rs6751559	chr2:28144894 - 28144894(1)	intron_variant
rs17759746	chr2:28171426 - 28171426(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p23.2	chr2:27700000-29800000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:27889941..28338901 View in gBrowse