Gene Report

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Basic Info

Approved Symbol	ZWINT
Symbol Alias	KNTC2AP, SIP30
Approved Name	ZW10 interacting kinetochore protein
Previous Name	ZW10 interactor
Name Alias	SNAP25 interacting protein of 30 kDa
Location	10q21-q22
Position	chr10:56357228-56361275, -1
External Links	HGNC: 13195 Entrez Gene: 11130 Ensembl: ENSG00000122952 UCSC: uc001jka.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000777	condensed chromosome kinetochore	cellular component	IEA	7
GO:0047485	protein N-terminus binding	molecular function	IPI[15485811]	12
GO:0051301	cell division	biological process	IEA	20
GO:0005515	protein binding	molecular function	IPI[15502821]	563
GO:0000070	mitotic sister chromatid segregation	biological process	IDA[15485811]	3
GO:0005829	cytosol	cellular component	TAS	223
GO:0051649	establishment of localization in cell	biological process	IDA[15485811]	2
GO:0007093	mitotic cell cycle checkpoint	biological process	IDA[15485811]	5
GO:0005737	cytoplasm	cellular component	IDA[11682612]	322
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0030425	dendrite	cellular component	IEA	65
GO:0000776	kinetochore	cellular component	IDA[11682612]	7

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZWINT	ZW10	NO	in vitro;in vivo	15485811 , 10806105 , 15824131 , 16732327
ZWINT	NDC80	NO	in vitro;yeast 2-hybrid	16732327
ZWINT	MIS12	NO	in vitro;in vivo	15502821
ZWINT	DSN1	NO	in vivo	15502821

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_12	chr10:56465084-58506956 (NCBI Build 36/hg18)	2	10q21.1	deletion

Gene related other variants (count: 0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11.21-q22.1	chr10:34200000-73100000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q11.21-q22.1	chr10:41600000-73100000	1 (0/0/1)
10q11-q21	chr10:39800000-68800000	1 (0/1/0)
10q21	chr10:51100000-68800000	4 (0/3/1)
10q21.1-2	chr10:51100000-62800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr10:56357228..56361275 View in gBrowse