Gene Report

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Basic Info

Approved Symbol	PHF20
Previous Symbol	C20orf104
Symbol Alias	dJ1121G12.1, TDRD20A
Approved Name	PHD finger protein 20
Previous Name	chromosome 20 open reading frame 104
Name Alias	tudor domain containing 20A
Location	20q11.22-q11.23
Position	chr20:35771974-35950381, 1
External Links	HGNC: 16098 Entrez Gene: 51230 Ensembl: ENSG00000025293 UCSC: uc002xek.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs6060612	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0071339	MLL1 complex	cellular component	IDA[15960975]	2
GO:0043982	histone H4-K8 acetylation	biological process	IDA[20018852]	1
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	molecular function	IDA[20018852]	1
GO:0006325	chromatin organization	biological process	TAS	14
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	molecular function	IDA[20018852]	1
GO:0043981	histone H4-K5 acetylation	biological process	IDA[20018852]	1
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	molecular function	IDA[20018852]	1
GO:0005515	protein binding	molecular function	IPI[16415788]	563
GO:0000123	histone acetyltransferase complex	cellular component	IDA[20018852]	2
GO:0043984	histone H4-K16 acetylation	biological process	IDA[20018852]	1
GO:0031965	nuclear membrane	cellular component	IDA	15
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0005737	cytoplasm	cellular component	IDA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6060612	chr20:35802605 - 35802605(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2378412		chr20:35888380 - 35888380(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs6058339		chr20:35872557 - 35872557(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:35771974..35950381 View in gBrowse