Gene Report

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Basic Info

Approved Symbol	RNASE4
Approved Name	ribonuclease, RNase A family, 4
Location	14q11
Position	chr14:20684100-20701215, 1
External Links	HGNC: 10047 Entrez Gene: 6038 Ensembl: ENSG00000258818 UCSC: uc001vya.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Winham S.J., 2014	SNP: rs5019558	No significant association of SNP in this gene with BD was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003676	nucleic acid binding	molecular function	IEA	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004522	pancreatic ribonuclease activity	molecular function	NAS[7742370]	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	biological process	NAS[7742370]	3
GO:0005576	extracellular region	cellular component	IDA[3467790]	97
GO:0009267	cellular response to starvation	biological process	IEA	6
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0006379	mRNA cleavage	biological process	NAS[7742370]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs5019558	chr14:20686090 - 20686090(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q11.2	chr14:18200000-24100000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q11.2-12.0	chr14:18200000-32900000	1 (0/1/0)
14q11.2-14q12	chr14:18200000-32900000	1 (0/0/1)
14q11.2-q13.1	chr14:18200000-34800000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:20684100..20701215 View in gBrowse