Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CIDEA
Symbol Alias	CIDE-A
Approved Name	cell death-inducing DFFA-like effector a
Location	18p11.21
Position	chr18:12254319-12277595, 1
External Links	HGNC: 1976 Entrez Gene: 1149 Ensembl: ENSG00000176194 UCSC: uc002kqt.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs115278913	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	ISS[17080483]	283

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	biological process	ISS[17080483]	3
GO:0019915	lipid storage	biological process	ISS	4
GO:0008219	cell death	biological process	ISS[17080483]	5
GO:0005811	lipid particle	cellular component	IDA[18509062]	2
GO:1902510	regulation of apoptotic DNA fragmentation	biological process	ISS[9564035]	2
GO:0005737	cytoplasm	cellular component	ISS[17080483]	322
GO:0050710	negative regulation of cytokine secretion	biological process	IMP[15919794]	2
GO:1900118	negative regulation of execution phase of apoptosis	biological process	ISS[17080483]	2
GO:0005740	mitochondrial envelope	cellular component	ISS	2
GO:0001659	temperature homeostasis	biological process	ISS	4
GO:0050995	negative regulation of lipid catabolic process	biological process	IMP[15919794]; ISS	6
GO:0032720	negative regulation of tumor necrosis factor production	biological process	IMP[15919794]	5
GO:0042803	protein homodimerization activity	molecular function	ISS[17080483]	71
GO:0042981	regulation of apoptotic process	biological process	IBA	10
GO:0006915	apoptotic process	biological process	IEA	39
GO:0006629	lipid metabolic process	biological process	ISS	10
GO:0010890	positive regulation of sequestering of triglyceride	biological process	ISS[18509062]	1
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0035634	response to stilbenoid	biological process	IEA	2
GO:0005739	mitochondrion	cellular component	ISS	75

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CIDEA	CIDEB	NO	in vivo	10837461
CIDEA	UCP1	NO	in vitro	12910269
CIDEA	ZBTB16	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs115278913	chr18:12277151 - 12277151(1)	3_prime_UTR_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18p11-q12.3	chr18:0-45900000	1 (0/0/1)
18pter-p11	chr18:0-18500000	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)
18p11	chr18:0-18500000	6 (1/2/3)
18p	chr18:0-18500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:12254319..12277595 View in gBrowse