SNP |
Related Gene(s) |
No. of Studies (Positive/Trend/Negative) for BD |
No. of Studies for MDD |
Overlap with MDD |
Statistical Results |
Description |
Result Category |
Reference |
|
rs2391191 |
DAOA
DAOA-AS1
|
18(3/0/15) |
3
|
Armitage's trend test:P-value = 0.13
Armitage's trend test:P-value = 0.13
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
A vs. G: OR = 0.98; 95% CI = 0.77–1.24; P-value = 0.855
A vs. G: OR = 0.98; 95% CI = 0.77–1.24; P-value = 0.855
|
No significant association was found between M15 and DD.
No significant association was found between M15 and DD.
|
Negative
|
Tan, J., 2014 |
For MDD, allele, P-value = 0.12;For Mood, allele, P-value =......
For MDD, allele, P-value = 0.12;For Mood, allele, P-value = 0.0465, OR=0.8524, P-value(perm)=0.888
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|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soronen, P.,2011 |
|
rs6265 |
BDNF
BDNF-AS
|
17(7/0/10) |
1
|
Armitage Trend Test:in Bonn sample, for MDD, P-value(odds r......
Armitage Trend Test:in Bonn sample, for MDD, P-value(odds ratio)=0.314(1.10);in Munich sample, for MDD, P-value(odds ratio)=0.881(1.02)
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|
No association was observed.
No association was observed.
|
Negative
|
Schumacher, J.,2005 |
|
rs1006737 |
CACNA1C
|
15(9/2/4) |
3
|
genotype test P-value = 0.013 when using New controls as co......
genotype test P-value = 0.013 when using New controls as control, genotype test P-value = 3.9E-4 when using WTCCC expanded reference as control, OR(%95 CI) = 1.15 (1.02-1.31) for allele test when using New controls as control, OR(%95 CI) = 1.17 (1.07-1.27) for allele test when using WTCCC expanded reference as control.
More...
|
We found that the risk allele conferred increased risk for ......
We found that the risk allele conferred increased risk for recurrent major depression (P= 0.013) with similar effect sizes to those previously observed in BD (allelic odds ratio B1.15).
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|
Positive
|
Green, E. K., 2010 |
Meta analysis:P-value = 3.1E-08
Meta analysis:P-value = 3.1E-08
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Liu, Y.,2011 |
genotypic P-value=0.33, X2=2.23; allelic P-value......
genotypic P-value=0.33, X2=2.23; allelic P-value=0.39, X2=0.75, OR (95%CI)=0.73 (0.36-1.48)
More...
|
no significant differences were observed in the genotype fr......
no significant differences were observed in the genotype frequencies compared with healthy subjects among MDD patients. However, allele frequencies were not significantly different in MDD compared with healthy subjects.
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|
Negative
|
Uemura, T., 2015 |
|
rs1935062 |
DAOA
DAOA-AS1
|
12(6/0/6) |
1
|
Armitage's trend test:P-value = 0.6
Armitage's trend test:P-value = 0.6
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
|
rs10994336 |
ANK3
|
12(7/0/5) |
1
|
Meta analysis:P-value = 5.0E-07
Meta analysis:P-value = 5.0E-07
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Liu, Y.,2011 |
|
rs3918342 |
DAOA
|
11(4/0/7) |
2
|
T vs. C: OR = 0.93; 95% CI = 0.83–1.03; P-value = 0.179
T vs. C: OR = 0.93; 95% CI = 0.83–1.03; P-value = 0.179
|
Significant association between M23 and DD was not found.
Significant association between M23 and DD was not found.
|
Negative
|
Tan, J., 2014 |
Armitage's trend test:P-value = 0.29
Armitage's trend test:P-value = 0.29
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
|
rs947267 |
DAOA
DAOA-AS1
|
9(1/0/8) |
2
|
C vs. A: OR= 1.05, 95% CI = 0.91–1.22, P-value = 0.476; C......
C vs. A: OR= 1.05, 95% CI = 0.91–1.22, P-value = 0.476; CC+CA vs. AA: OR = 1.09, 95%CI = 0.88–1.34, P-value = 0.43; CC vs. CA+AA: OR = 1.05, 95% CI = 0.79–1.40, P-value = 0.748; CC vs. CA: OR = 1.01, 95% CI = 0.75–1.37, P-value = 0.941; CA vs. AA: OR = 1.08, 95% CI = 0.87–1.35, P-value = 0.475; CC vs. AA: OR= 1.10, 95% CI= 0.80–1.51, P-value = 0.544.
More...
|
No significant association was found between M18 and DD in ......
No significant association was found between M18 and DD in six models.
More...
|
Negative
|
Tan, J., 2014 |
Armitage's trend test:P-value = 0.99
Armitage's trend test:P-value = 0.99
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
|
rs2230912 |
P2RX7
|
9(2/0/7) |
4
|
Chi-square analysis:1.allele:overall group: X2(1......
Chi-square analysis:1.allele:overall group: X2(1)=1.86, P-value = 0.17; for MDD: X2(1)=0.94, P-value = 0.33; for BPD: X2(1)=1.64, P-value = 0.20 2.genptype:overall group:X2(2, 349)=1.91, P-value = 0.38;for MDD: X2(2, 285)=0.99, P-value = 0.61; for BPD: X2(2242)=1.66, P-value = 0.44 multivariate analysis of variance (MANOVA):1.Genotype GG:Clinical group:F(2, 149)=4.568, P-value(ANOVA)=0.0119 in HADS-anxiety scale;F(2, 149)=8.319, P-value(ANOVA)=0.0004 in HADS-depression scale;Control group:F(2, 134)=0.055, P-value(ANOVA)=0.947 in HADS-anxiety scale;F(2, 134)=0.263, P-value(ANOVA)=0.769 in HADS-depression scale 2.Genotype AG+GG:Clinical group:F(1, 150)=3.949, P-value(ANOVA)=0.00487 in HADS-anxiety scale;F(1.150)=13.091, P-value(ANOVA)=0.0004 in HADS-depression scale;Control group:F(1, 135)=0.021, P-value(ANOVA)=0.884 in HADS-anxiety scale;F(1, 135)=0.024, P-value(ANOVA)=0.876 in HADS-depression scale 3.interaction of clinical status and P2RX7 polymorphism:P-value(ANOVA)=0.025, subsequent ANOVA for anxiety:P-value(ANOVA)=0.252; depression: P-value(ANOVA)=0.002.
More...
|
The case-control analysis did not yield significant results......
The case-control analysis did not yield significant results, comparing either the overall patient sample, or the MDD and BPD groups separately to the control group.Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups.A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale.
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|
Positive
|
Hejjas, K.,2009 |
P-value>0.05
P-value>0.05
|
The case-control analyses did not show any significant diff......
The case-control analyses did not show any significant difference in the genotype distributions of the two investigated P2RX7 polymorphisms (i.e.,rs2230912 and rs1653625) between the MDD or the BPD and the control groups.
More...
|
Negative
|
Halmai Z, 2013 |
For MDD, allele, P-value = 0.0217;For Mood, allele, P-value......
For MDD, allele, P-value = 0.0217;For Mood, allele, P-value = 0.0172, OR=1.287, P-value(perm)=0.586
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soronen, P.,2011 |
Allelic Association Analysis and Genotype Frequencies of SN......
Allelic Association Analysis and Genotype Frequencies of SNP rs2230912 (P2 RX7):P-value = 0.834(Armitage trend test), Corrected global P-value = 0.840 and Genotype:P-value = 0.772(2 df)in German Mdd-UP vs. German control sample
More...
|
we observed no significant differences between German Mdd-......
we observed no significant differences between German Mdd-UP samples and German control.
More...
|
Negative
|
Grigoroiu-Serbanescu, M.,2009 |
|
rs1170191 |
DGKH
|
7(1/0/6) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs1935058 |
DAOA-AS1
DAOA
|
7(3/0/4) |
1
|
Armitage's trend test:P-value = 0.3
Armitage's trend test:P-value = 0.3
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
|
rs165599 |
ARVCF
COMT
|
7(5/0/2) |
2
|
For MD:allele, X2=3.58, P-value = 0.05, genotype......
For MD:allele, X2=3.58, P-value = 0.05, genotype, X2=4.35, P-value = 0.1;eraly onset:allele, X2=2.56, P-value = 0.11, genotype, X2=3.25, P-value = 0.2
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Massat, I.,2011 |
Allelic association:for MDD, P-value = 0.169, trend P-value......
Allelic association:for MDD, P-value = 0.169, trend P-value = 0.184, OR (95%CI)=1.46(0.85, 2.51)
More...
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Funke, B.,2005 |
|
rs1012053 |
DGKH
|
6(1/0/5) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs1801260 |
CLOCK
TMEM165
|
6(3/0/3) |
3
|
For MDD:Allele T, unadjusted analyses, OR=1.12, 95%CI=0.790......
For MDD:Allele T, unadjusted analyses, OR=1.12, 95%CI=0.790-1.59, P-value = 0.519;adjusted analyses, OR=1.13, 95%CI=0.785-1.59, P-value = 0.542. Recessive:genotype TT and TC, unadjusted analyses, OR=1.07, 95%CI=0.359-2.57, P-value = 0.893;adjusted analyses, OR=1.08, 95%CI=0.364-2.62, P-value = 0.87 .Dominant:genotype TT, unadjusted analyses, OR=0.85, 95%CI=0.562-1.26, P-value = 0.428;adjusted analyses, OR=0.847, 95%CI=0.560-1.26, P-value = 0.422. Co-dominant:genotype TT, unadjusted analyses, OR=0.898, 95%CI=0.401-1.78, P-value = 0.761;adjusted analyses, OR=0.898, 95%CI=0.403-1.79, P-value = 0.773;Co-dominant:genotype TC, unadjusted analyses, OR=1.3, 95%CI=0.550-2.86, P-value = 0.525;adjusted analyses, OR=1.32, 95%CI=0.557-2.91, P-value = 0.504
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Kishi, T.,2011(c) |
chi-square test: 1. total samples:P-value = 0.833(Genotype)......
chi-square test: 1. total samples:P-value = 0.833(Genotype), P-value = 0.972(Allele) in MDD 2. male samples: P-value = 0.451(Genotype), P-value = 0.746(Allele) in MDD 3. female samples: P-value = 0.648(Genotype), P-value = 0.872(Allele) in MDD
More...
|
We did not find an association between these tag SNPs and J......
We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses.
More...
|
Negative
|
Kishi, T.,2009(a) |
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs9315885 |
DGKH
MAPK6PS3
|
6(0/0/6) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs4680 |
COMT
|
6(3/0/3) |
2
|
For MD:allele, X2=0.82, P-value = 0.36, genotype......
For MD:allele, X2=0.82, P-value = 0.36, genotype, X2=6.6, P-value = 0.03;eraly onset:allele, X2=0.83, P-value = 0.36, genotype, X2=5.62, P-value = 0.05
More...
|
Significant association was found in genotype for MD.
Significant association was found in genotype for MD.
|
Positive
|
Massat, I.,2011 |
Allelic association:for MDD, P-value = 0.101, trend P-value......
Allelic association:for MDD, P-value = 0.101, trend P-value = 0.093, OR (95%CI)=1.56(0.91, 2.68)
More...
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Funke, B.,2005 |
|
rs3738401 |
DISC1
TSNAX
|
5(0/0/5) |
1
|
genotypic/allelic test P-value: 0.77/0.59
genotypic/allelic test P-value: 0.77/0.59
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs1487275 |
TPH2
|
5(0/0/5) |
1
|
|
rs737865 |
COMT
TXNRD2
|
5(2/0/3) |
2
|
For MD:allele, X2=0.85, P-value = 0.35, genotype......
For MD:allele, X2=0.85, P-value = 0.35, genotype, X2=1.25, P-value = 0.52;eraly onset:allele, X2=3.95, P-value = 0.04, genotype, X2=4.3, P-value = 0.12
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Massat, I.,2011 |
Allelic association:for MDD, P-value = 0.688, trend P-value......
Allelic association:for MDD, P-value = 0.688, trend P-value = 0.689, OR (95%CI)=1.12(0.64, 1.95)
More...
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Funke, B.,2005 |
|
rs2251219 |
PBRM1
SMIM4
RNU6-856P
|
5(5/0/0) |
2
|
P-value=0.008059, OR=1.062 for MDD, P-value=0.00000001913, ......
P-value=0.008059, OR=1.062 for MDD, P-value=0.00000001913, OR=1.1 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.2.
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|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs2251219 was significantly associated with major mood diso......
rs2251219 was significantly associated with major mood disorder. The findings were more robust in bipolar disorder than in MDD.The result is replicable in replication samples. We did not find a significant association signal at any of these loci after genome-wide correction for multiple testing. Our genetic association results provide support for the previous epidemiologic evidence of genetic overlap between bipolar disorder and MDD.
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|
Positive
|
McMahon, F. J., 2010 |
|
rs9371601 |
SYNE1
|
5(4/1/0) |
1
|
Association analysis:genotype trend P-value = 0.063, allele......
Association analysis:genotype trend P-value = 0.063, allele OR (95% CI)=1.111 (0.99--1.24) with independent control;genotype trend P-value = 0.032, allele OR (95% CI)=1.118 (1.01--1.24) with all controls (WTCCC and independent)
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Green EK, 2013 |
|
rs11178997 |
TPH2
|
5(1/0/4) |
1
|
genotypic P-value = 0.001, allelic P-value = 0.001
genotypic P-value = 0.001, allelic P-value = 0.001
|
In the sample of patients with UP disorder and controls, si......
In the sample of patients with UP disorder and controls, significant association was observed for the A allele of rs11178997.
More...
|
Positive
|
Van Den Bogaert, A., 2006 (a) |
|
rs766288 |
TSNAX
DISC1
|
4(1/0/3) |
2
|
chi square test:genotype P-value = 0.0742, allele P-value =......
chi square test:genotype P-value = 0.0742, allele P-value = 0.0727
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Okuda, A.,2010 |
genotypic/allelic test P-value: 0.27/0.15
genotypic/allelic test P-value: 0.27/0.15
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs1000731 |
DISC1
TSNAX
|
4(0/0/4) |
1
|
genotypic/allelic test P-value: 0.84/0.57
genotypic/allelic test P-value: 0.84/0.57
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs4792887 |
CRHR1
MAPT-AS1
|
4(0/0/4) |
1
|
allelic P-value=0.201, genotypic P-value=0.266, OR=1.631, 9......
allelic P-value=0.201, genotypic P-value=0.266, OR=1.631, 95% CI=0.665-1.080 for affective disorder; allelic P-value=0.431, genotypic P-value=0.443, OR=0.853, 95% CI=0.598-1.218 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs110402 |
CRHR1
MAPT-AS1
|
4(0/0/4) |
1
|
allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 9......
allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 95% CI=0.755-1.013 for affective disorder; allelic P-value=0.144, genotypic P-value=0.238, OR=0.852, 95% CI=0.689-1.054 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs1360780 |
FKBP5
|
4(0/0/4) |
1
|
P-value=0.011
P-value=0.011
|
Our main finding is an association of FKBP5 polymorphisms (......
Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.
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|
Positive
|
Szczepankiewicz A., 2014 |
|
rs6313 |
HTR2A
|
4(0/0/4) |
2
|
Overall: T vs. C (Allele frequency): OR=1.006, 95%CI=0.914-......
Overall: T vs. C (Allele frequency): OR=1.006, 95%CI=0.914-1.107, P-value=0.908; TT + TC vs. CC (Dominant): OR=0.999, 95%CI=0.845-1.181, P-value=0.994; TT vs. TC + CC (Recessive): OR=1.033, 95%CI=0.919-1.161, P-value=0.592; TT vs. TC (Codominant1): OR=1.022, 95%CI=0.903-1.158, P-value=0.73; TC vs. CC (Codominant2): OR=1.012, 95%CI=0.891-1.148, P-value=0.856; TT vs. CC (Homozygote): OR=0.993, 95%CI=0.807-1.222, P-value=0.949. Caucasian: T vs. C (Allele frequency): OR=1.055, 95%CI=0.894-1.246, P-value=0.528; TT + TC vs. CC (Dominant): OR=1.085, 95%CI=0.806-1.461, P-value=0.689; TT vs. TC + CC (Recessive): OR=1.068, 95%CI=0.852-1.339, P-value=0.568; TT vs. TC (Codominant1): OR=1.028, 95%CI=0.809-1.306, P-value=0.824; TC vs. CC (Codominant2): OR=1.085, 95%CI=0.878-1.342, P-value=0.449; TT vs. CC (Homozygote): OR=1.092, 95%CI=0.781-1.527, P-value=0.607. Asian: T vs. C (Allele frequency): OR=0.980, 95%CI=0.868-1.106, P-value=0.743; TT + TC vs. CC (Dominant): OR=0.950, 95%CI=0.772-1.169, P-value=0.629; TT vs. TC + CC (Recessive): OR=1.020, 95%CI=0.890-1.169, P-value=0.778; TT vs. TC (Codominant1): OR=1.020, 95%CI=0.882-1.180, P-value=0.788; TC vs. CC (Codominant2): OR=0.973, 95%CI=0.831-1.139, P-value=0.737; TT vs. CC (Homozygote): OR=0.936, 95%CI=0.713-1.229, P-value=0.635. Chinese: T vs. C (Allele frequency): OR=1.008, 95%CI=0.864-1.177, P-value=0.917; TT + TC vs. CC (Dominant): OR=1.034, 95%CI=0.850-1.259, P-value=0.736; TT vs. TC + CC (Recessive): OR=1.042, 95%CI=0.877-1.238, P-value=0.637; TT vs. TC (Codominant1): OR=1.021, 95%CI=0.851-1.225, P-value=0.823; TC vs. CC (Codominant2): OR=1.026, 95%CI=0.833-1.264, P-value=0.81; TT vs. CC (Homozygote): OR=0.977, 95%CI=0.664-1.436, P-value=0.905
More...
|
The results of our study indicate that theT102C polymorphis......
The results of our study indicate that theT102C polymorphism is not associates with increased susceptibility to MDD.
More...
|
Negative
|
Tan J., 2014 |
chi-square test: 1.total samples:P-value = 0.430(Genotype),......
chi-square test: 1.total samples:P-value = 0.430(Genotype), P-value = 0.254(Allele) in Mood disorders;P-value = 0.883(Genotype), P-value = 0.656(Allele) in MDD 2. male samples: P-value = 0.424(Genotype), P-value = 0.240(Allele) in Mood disorders;P-value = 0.616(Genotype), P-value = 0.361(Allele) in MDD 3. female samples: P-value = 0.310(Genotype), P-value = 0.731(Allele) in Mood disorders;P-value = 0.763(Genotype), P-value = 0.732(Allele) in MDD
More...
|
we did not detect any significant association of HTR2A with......
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(b) |
|
rs6675281 |
DISC1
TSNAX
|
4(0/0/4) |
1
|
genotypic/allelic test P-value: 0.47/0.23
genotypic/allelic test P-value: 0.47/0.23
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs3916966 |
DAOA-AS1
DAOA
|
4(1/0/3) |
1
|
Armitage's trend test:P-value = 0.54
Armitage's trend test:P-value = 0.54
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
|
rs6196 |
NR3C1
|
4(1/0/3) |
1
|
X2 test:allele, P-value > 0.05;the Fisher exact ......
X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A.,2011 |
|
rs10052957 |
NR3C1
|
4(1/0/3) |
1
|
X2 test:allele, P-value > 0.05;the Fisher exact ......
X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A.,2011 |
|
rs6198 |
NR3C1
|
4(0/0/4) |
1
|
X2 test:allele, P-value > 0.05;the Fisher exact ......
X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value = 0.018, df=2, X2=7.964, OR=0.950, 95% CI: 0.693-1.303.
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Szczepankiewicz, A.,2011 |
|
rs1843809 |
TPH2
|
4(1/0/3) |
1
|
|
rs258813 |
NR3C1
|
3(0/0/3) |
1
|
X2 test:allele, P-value > 0.05;the Fisher exact ......
X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A.,2011 |
|
rs1982350 |
ARNTL
|
3(2/0/1) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs1630250 |
TSNAX
DISC1
|
3(0/0/3) |
1
|
chi square test:genotype P-value = 0.356, allele P-value = ......
chi square test:genotype P-value = 0.356, allele P-value = 0.165
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Okuda, A.,2010 |
|
rs3789327 |
ARNTL
|
3(2/0/1) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs242950 |
CRHR1
MAPT-AS1
|
3(0/0/3) |
1
|
allelic P-value=0.407, genotypic P-value=0.671, OR=0.901, 9......
allelic P-value=0.407, genotypic P-value=0.671, OR=0.901, 95% CI=0.716-1.134 for affective disorder; allelic P-value=0.867, genotypic P-value=0.958, OR=0.954, 95% CI=0.686-1.327 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs28536160 |
AVPR1B
|
3(1/0/2) |
1
|
allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 9......
allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 95% CI=0.607-1.067 for affective disorder; allelic P-value=1, genotypic P-value=0.387, OR=1.001, 95% CI=0.662-1.514 for MDD
More...
|
In the single marker association analysis of AVPR1b gene we......
In the single marker association analysis of AVPR1b gene we observed an association of rs28536160 with mood disorders (P=0.036); this was not observed in the bipolar disorder and MDD patients separately.
More...
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs41423247 |
NR3C1
|
3(0/0/3) |
1
|
X2 test:allele, P-value > 0.05;the Fisher exact ......
X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A.,2011 |
|
rs2535629 |
ITIH3
|
3(3/0/0) |
2
|
Association analysis:P-value = 0.00000000000254,OR(95%CI) =......
Association analysis:P-value = 0.00000000000254,OR(95%CI) = 1.1(1.07–1.12) when five disorders were combined
More...
|
Significant association was observed in cross-disorder anal......
Significant association was observed in cross-disorder analysis.
More...
|
Positive
|
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 |
P-value=0.0009575, OR=0.9239 for MDD, P-value=0.00000000588......
P-value=0.0009575, OR=0.9239 for MDD, P-value=0.000000005883, OR=0.8998 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.1.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs6191 |
NR3C1
|
3(0/0/3) |
1
|
X2 test:allele, P-value = 0.015 for alleles, OR=......
X2 test:allele, P-value = 0.015 for alleles, OR=1.338, 95% CI: 1.059-1.689;the Fisher exact test:genotype, P-value = 0.049
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Szczepankiewicz, A.,2011 |
|
rs2071427 |
NR1D1
THRA
|
3(1/0/2) |
2
|
Hardy-Weinberg equilibrium P value=0.600, genotypic P value......
Hardy-Weinberg equilibrium P value=0.600, genotypic P value=0.911, allelic P value=0.706 for MDD.
More...
|
No significant association was found with major depressive ......
No significant association was found with major depressive disorder.
More...
|
Negative
|
Kishi, T., 2008 (b) |
X2-tests:allele P-value = 0.235, Model Recessive......
X2-tests:allele P-value = 0.235, Model Recessive, genotype P-value = 0.039, OR(95%CI)=1.80 (1.03-3.16)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs2492367 |
DISC1
TSNAX
|
3(1/0/2) |
1
|
genotypic/allelic test P-value: 0.31/0.97
genotypic/allelic test P-value: 0.31/0.97
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs6850524 |
CLOCK
|
3(2/0/1) |
1
|
X2-tests:allele P-value = 0.056, Model Log-addit......
X2-tests:allele P-value = 0.056, Model Log-additive, genotype P-value = 0.015, OR(95%CI)=1.30 (1.05-1.61)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs3800373 |
FKBP5
|
3(1/0/2) |
1
|
P-value=0.083
P-value=0.083
|
association analysis for single polymorphisms within FKBP5 ......
association analysis for single polymorphisms within FKBP5 gene
More...
|
Negative
|
Szczepankiewicz A., 2014 |
|
rs6903874 |
TAAR6
|
3(1/0/2) |
1
|
|
The significant association of rs6903874 with BID was not o......
The significant association of rs6903874 with BID was not observed in the overall groups of patients with MDD nor in the patients with psychotic MDD vs. controls.
More...
|
Negative
|
Pae, C. U., 2008 |
|
rs2278749 |
ARNTL
|
3(1/0/2) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs10748185 |
TPH2
|
3(2/0/1) |
1
|
|
rs3736544 |
CLOCK
TMEM165
|
3(1/0/2) |
2
|
For MDD:Allele G, unadjusted analyses, OR=0.783, 95%CI=0.58......
For MDD:Allele G, unadjusted analyses, OR=0.783, 95%CI=0.585-1.05, P-value = 0.0989;adjusted analyses, OR=0.787, 95%CI=0.588-1.05, P-value = 0.106. Recessive:genotype GG and GT, unadjusted analyses, OR=2.19, 95%CI=1.10-4.10, P-value = 0.0187(0.224);adjusted analyses, OR=2.23, 95%CI=1.11-4.20, P-value = 0.0174(0.209) .Dominant:genotype GG, unadjusted analyses, OR=1.18, 95%CI=0.818-1.69, P-value = 0.372;adjusted analyses, OR=1.12, 95%CI=0.774-1.60, P-value = 0.551. Co-dominant:genotype GG, unadjusted analyses, OR=1.75, 95%CI=0.986-3.04, P-value = 0.0506;adjusted analyses, OR=1.67, 95%CI=0.939-2.92, P-value = 0.074;Co-dominant:genotype GT, unadjusted analyses, OR=0.161, 95%CI=0.873-2.96, P-value = 0.123;adjusted analyses, OR=1.74, 95%CI=0.940-3.21, P-value = 0.0751
More...
|
Significant association was observed in recessive model , b......
Significant association was observed in recessive model , but this significance did not survive Bonferroni correction.
More...
|
Positive
|
Kishi, T.,2011(c) |
chi-square test: 1. total samples: P-value = 0.914(Genotype......
chi-square test: 1. total samples: P-value = 0.914(Genotype), P-value = 0.334(Allele) in MDD 2. male samples: P-value = 0.160(Genotype), P-value = 0.229(Allele) in MDD 3. female samples: P-value = 0.233(Genotype), P-value = 0.316(Allele) in MDD
More...
|
We did not find an association between these tag SNPs and J......
We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses.
More...
|
Negative
|
Kishi, T.,2009(a) |
|
rs28373064 |
AVPR1B
|
3(0/0/3) |
1
|
allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 9......
allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 95% CI=0.766-1.119 for affective disorder; allelic P-value=0.514, genotypic P-value=0.399, OR=1.099, 95% CI=0.830-1.454 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs821597 |
DISC1
TSNAX
|
3(0/0/3) |
1
|
genotypic/allelic test P-value: 0.40/0.28
genotypic/allelic test P-value: 0.40/0.28
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs33388 |
NR3C1
|
3(0/0/3) |
1
|
X2 test:allele, P-value = 0.018, OR=0.759, 95% C......
X2 test:allele, P-value = 0.018, OR=0.759, 95% CI=0.605-0.953;the Fisher exact test:genotype, P-value > 0.05
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Szczepankiewicz, A.,2011 |
|
rs646558 |
NCAM1
|
3(1/0/2) |
1
|
Fisher's exact test genotypic P-value = 0.51 , allelic P-va......
Fisher's exact test genotypic P-value = 0.51 , allelic P-value = 0.64
More...
|
For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...
|
Negative
|
Arai, M., 2004 |
|
rs1997644 |
CSNK1E
|
3(2/0/1) |
2
|
Chi square test:MAF = 0.37,P-value = 0.49,OR = 0.95
Chi square test:MAF = 0.37,P-value = 0.49,OR = 0.95
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs173365 |
CRHR1
MAPT-AS1
|
3(0/0/3) |
1
|
allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 9......
allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 95% CI=0.877-1.180 for affective disorder; allelic P-value=0.476, genotypic P-value=0.469, OR=1.088, 95% CI=0.876-1.350 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs1800532 |
TPH1
|
3(1/0/2) |
1
|
Meta analysis:On the basis of the random effect model, P-va......
Meta analysis:On the basis of the random effect model, P-value > 0.05 in any genetic models either in Caucasians or in Asians.
More...
|
On the basis of the random effect model, no significant ass......
On the basis of the random effect model, no significant association between TPH1 A218C polymorphism and MDD risk was found in any genetic models either in Caucasians or in Asians.
More...
|
Negative
|
Chen, D.,2011 |
|
rs9296158 |
FKBP5
|
3(1/0/2) |
1
|
P-value=0.03
P-value=0.03
|
Our main finding is an association of FKBP5 polymorphisms (......
Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.
More...
|
Positive
|
Szczepankiewicz A., 2014 |
|
rs9315897 |
DGKH
|
3(0/0/3) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs28632197 |
AVPR1B
|
3(0/0/3) |
1
|
allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 9......
allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 95% CI=0.763-1.244 for affective disorder; allelic P-value=0.397, genotypic P-value=0.353, OR=0.853, 95% CI=0.597-1.219 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs4076452 |
CRHR1
|
3(0/0/3) |
1
|
allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 9......
allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 95% CI=0.940-1.386 for affective disorder; allelic P-value=0.177, genotypic P-value=0.02, OR=1.225, 95% CI=0.917-1.635 for MDD
More...
|
We found that rs4076452 was significantly associated with a......
We found that rs4076452 was significantly associated with an increased risk for MDD in our group.
More...
|
Positive
|
Szczepankiewicz, A., 2013 |
|
rs878886 |
CRHR1
MAPT-AS1
|
3(0/0/3) |
1
|
allelic P-value=0.113, genotypic P-value=0.258, OR=1.176, 9......
allelic P-value=0.113, genotypic P-value=0.258, OR=1.176, 95% CI=0.967-1.430 for affective disorder; allelic P-value=0.768, genotypic P-value=0.941, OR=1.047, 95% CI=0.785-1.394 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs35369693 |
AVPR1B
|
3(0/0/3) |
1
|
allelic P-value=0.729, genotypic P-value=0.907, OR=0.934, 9......
allelic P-value=0.729, genotypic P-value=0.907, OR=0.934, 95% CI=0.682-1.279 for affective disorder; allelic P-value=0.71, genotypic P-value=0.797, OR=0.925, 95% CI=0.573-1.492 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs1049353 |
CNR1
|
2(0/0/2) |
1
|
Pearson's X2 test: X2= 10.321; df = 2......
Pearson's X2 test: X2= 10.321; df = 2, P-value = 0.005 for genotypes; X2= 12.469;df = 1, P-value = 0.0004 for alleles
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Monteleone, P.,2010 |
|
rs9470080 |
FKBP5
|
2(0/0/2) |
1
|
P-value=0.007
P-value=0.007
|
Our main finding is an association of FKBP5 polymorphisms (......
Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.
More...
|
Positive
|
Szczepankiewicz A., 2014 |
|
rs2156921 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value = 0.031, OR=1.29
Allelic association:for MDD, P-value = 0.031, OR=1.29
|
Significant associations were found in MDD.
Significant associations were found in MDD.
|
Positive
|
Hashimoto, R.,2005(a) |
|
rs988748 |
BDNF
|
2(0/0/2) |
1
|
Armitage Trend Test:in Bonn sample, for MDD, P-value(odds r......
Armitage Trend Test:in Bonn sample, for MDD, P-value(odds ratio)=0.651(1.04);in Munich sample, for MDD, P-value(odds ratio)=0.470(1.10)
More...
|
No association was observed.
No association was observed.
|
Negative
|
Schumacher, J.,2005 |
|
rs2267013 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value = 0.044, OR=1.27
Allelic association:for MDD, P-value = 0.044, OR=1.27
|
Significant associations were found in MDD.
Significant associations were found in MDD.
|
Positive
|
Hashimoto, R.,2005(a) |
|
rs3755806 |
PBRM1
|
2(1/1/0) |
1
|
P-value=0.006818, OR=1.063 for MDD, P-value=0.00000003091, ......
P-value=0.006818, OR=1.063 for MDD, P-value=0.00000003091, OR=1.098 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.8.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs131702 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value > 0.05
Allelic association:for MDD, P-value > 0.05
|
No significant associations were found in MDD.
No significant associations were found in MDD.
|
Negative
|
Hashimoto, R.,2005(a) |
|
rs140504 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value > 0.05
Allelic association:for MDD, P-value > 0.05
|
No significant associations were found in MDD.
No significant associations were found in MDD.
|
Negative
|
Hashimoto, R.,2005(a) |
|
rs1611115 |
DBH
|
2(1/0/1) |
1
|
DBH genotype and affective disorders:total(X2 = ......
DBH genotype and affective disorders:total(X2 = 0.55, P-value = 0.758), Unipolar(X2 = 2.05, P-value = 0.359), Bipolar(X2 = 0.90, P-value = 0.638)
More...
|
No differences in DBH C-1021T genotype distribution were ob......
No differences in DBH C-1021T genotype distribution were observed
More...
|
Negative
|
Hess, C.,2009 |
|
rs778336 |
DAOA-AS1
DAOA
|
2(0/0/2) |
1
|
For MDD, allele, P-value = 0.0406;For Mood, allele, P-value......
For MDD, allele, P-value = 0.0406;For Mood, allele, P-value = 0.031, OR=0.8072, P-value(perm)=0.769
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soronen, P.,2011 |
|
rs969486 |
ARNTL
|
2(1/0/1) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs3794808 |
SLC6A4
|
2(0/0/2) |
1
|
For MDD, allele, P-value = 0.0046;For Mood, allele, P-value......
For MDD, allele, P-value = 0.0046;For Mood, allele, P-value = 0.0115, OR=0.8167, P-value(perm)=0.432
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soronen, P.,2011 |
|
rs956572 |
BCL2
|
2(0/0/2) |
1
|
chi-square tests:genotype, MDD(P-value = 0.31, X2
chi-square tests:genotype, MDD(P-value = 0.31, X2=2.32);allele, MDD[P-value = 0.89;OR = 0.95, 95% CI:(0.52-1.75), X2=0.02]
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Uemura, T.,2011 |
|
rs324420 |
FAAH
|
2(0/0/2) |
1
|
Pearson's X2 test:Genotype frequencies with MD p......
Pearson's X2 test:Genotype frequencies with MD patients ( X2=3.748;df = 1, P-value = 0.05)
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Monteleone, P.,2010 |
|
rs2267020 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value > 0.05
Allelic association:for MDD, P-value > 0.05
|
No significant associations were found in MDD.
No significant associations were found in MDD.
|
Negative
|
Hashimoto, R.,2005(a) |
|
rs1024582 |
CACNA1C
CACNA1C-IT3
|
2(2/0/0) |
1
|
|
rs12504300 |
CLOCK
|
2(2/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs228642 |
PER3
|
2(1/0/1) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs12936511 |
CRHR1
MAPT-AS1
|
2(0/0/2) |
1
|
allelic P-value=0.362, genotypic P-value=0.269, OR=0.828, 9......
allelic P-value=0.362, genotypic P-value=0.269, OR=0.828, 95% CI=0.603-1.180 for affective disorder; allelic P-value=0.904, genotypic P-value=0.962, OR=0.947, 95% CI=0.587-1.526 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs939347 |
NR1D1
|
2(0/0/2) |
1
|
Hardy-Weinberg equilibrium P value=0.178, genotypic P value......
Hardy-Weinberg equilibrium P value=0.178, genotypic P value=0.907, allelic P value=0.831 for MDD.
More...
|
No significant association was found with major depressive ......
No significant association was found with major depressive disorder.
More...
|
Negative
|
Kishi, T., 2008 (b) |
|
rs13440581 |
GPR50
GPR50-AS1
|
2(1/0/1) |
2
|
X2 goodness of fit test:P-value > 0.05
X2 goodness of fit test:P-value > 0.05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Macintyre, D. J.,2010 |
Single marker association:for MDD, allele P-value = 0.04(al......
Single marker association:for MDD, allele P-value = 0.04(all), P-value = 0.99(male), P-value = 0.0096(female)
More...
|
Association was observed in MDD and MDD(female).
Association was observed in MDD and MDD(female).
|
Positive
|
Thomson, P. A.,2005(b) |
|
rs723672 |
CACNA1C
CACNA1C-IT2
|
2(0/0/2) |
1
|
genotypic P-value=0.56, X2=1.16, allelic P-value......
genotypic P-value=0.56, X2=1.16, allelic P-value=0.56, OR(95%CI)=1.05(0.88-1.26)
More...
|
Neither allele nor genotype frequencies of the three SNPs w......
Neither allele nor genotype frequencies of the three SNPs were significantly different between MDD patients and control subjects.
More...
|
Negative
|
Zhang X, 2013 |
|
rs12966547 |
CCDC68
|
2(2/0/0) |
1
|
|
rs878567 |
HTR1A
|
2(1/0/1) |
1
|
Meta analysis:P (allele model) = 0.0007 and P (dominant mod......
Meta analysis:P (allele model) = 0.0007 and P (dominant model) = 0.01
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Kishi, T.,2012(a) |
|
rs41279104 |
NOS1
|
2(0/0/2) |
1
|
genotype test P-value = 0.787, allele test P-value = 0.531.
genotype test P-value = 0.787, allele test P-value = 0.531.
|
no association was observed.
no association was observed.
|
Negative
|
Okumura, T., 2010 |
|
rs17025005 |
NPAS2
|
2(1/0/1) |
1
|
X2-tests:allele P-value = 0.092, Model Dominant,......
X2-tests:allele P-value = 0.092, Model Dominant, genotype P-value = 0.039, OR(95%CI)=0.72 (0.53-0.98)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs755658 |
FKBP5
|
2(0/0/2) |
1
|
P-value=0.46
P-value=0.46
|
association analysis for single polymorphisms within FKBP5 ......
association analysis for single polymorphisms within FKBP5 gene
More...
|
Negative
|
Szczepankiewicz A., 2014 |
|
rs1928040 |
HTR2A
|
2(0/0/2) |
1
|
chi-square test: 1.total samples:P-value = 0.894(Genotype),......
chi-square test: 1.total samples:P-value = 0.894(Genotype), P-value = 0.888(Allele) in Mood disorders;P-value = 0.370(Genotype), P-value = 0.499(Allele) in MDD 2. male samples: P-value = 0.929(Genotype), P-value = 0.977(Allele) in Mood disorders;P-value = 0.623(Genotype), P-value = 0.524(Allele) in MDD 3. female samples: P-value = 0.930(Genotype), P-value = 0.837(Allele) in Mood disorders;P-value = 0.551(Genotype), P-value = 0.771(Allele) in MDD
More...
|
we did not detect any significant association of HTR2A with......
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(b) |
|
rs6465084 |
GRM3
|
2(0/0/2) |
1
|
For MDD:Genotypic association:P-value = 0.0344, allelic ass......
For MDD:Genotypic association:P-value = 0.0344, allelic association:P-value = 0.00928
More...
|
We found an association between rs6465084 in GRM3 and MDD i......
We found an association between rs6465084 in GRM3 and MDD in the allele-wise analysis after Bonferroni's correction.
More...
|
Positive
|
Tsunoka, T.,2009 |
|
rs6438552 |
GSK3B
|
2(0/0/2) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.228, dominant P-value = 0.277, recessive P-value = 0.109, additive P-value = 0.102
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs4279178 |
GABRB1
ADM
|
2(1/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs3761418 |
BCR
BCRP8
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value = 0.012, OR=1.32
Allelic association:for MDD, P-value = 0.012, OR=1.32
|
Significant associations were found in MDD.
Significant associations were found in MDD.
|
Positive
|
Hashimoto, R.,2005(a) |
|
rs2279287 |
ARNTL
|
2(1/0/1) |
1
|
X2-tests:allele P-value = 0.178, Model Dominant,......
X2-tests:allele P-value = 0.178, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.71 (0.53-0.95)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs2213172 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value = 0.031, OR=1.28
Allelic association:for MDD, P-value = 0.031, OR=1.28
|
Significant associations were found in MDD.
Significant associations were found in MDD.
|
Positive
|
Hashimoto, R.,2005(a) |
|
rs1610037 |
ADCYAP1
|
2(1/0/1) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs208294 |
P2RX7
|
2(0/0/2) |
1
|
For MDD, allele, P-value = 0.007;For Mood, allele, P-value ......
For MDD, allele, P-value = 0.007;For Mood, allele, P-value = 0.0033, OR=1.26, P-value(perm)=0.158
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soronen, P.,2011 |
|
rs2072621 |
GPR50
GPR50-AS1
|
2(0/0/2) |
2
|
X2 goodness of fit test:P-value > 0.05
X2 goodness of fit test:P-value > 0.05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Macintyre, D. J.,2010 |
Single marker association:for MDD, allele P-value = 0.58(al......
Single marker association:for MDD, allele P-value = 0.58(all), P-value = 0.19(male), P-value = 0.97(female)
More...
|
No association was observed.
No association was observed.
|
Negative
|
Thomson, P. A.,2005(b) |
|
rs4713916 |
FKBP5
|
2(0/0/2) |
1
|
P-value=0.038
P-value=0.038
|
Our main finding is an association of FKBP5 polymorphisms (......
Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.
More...
|
Positive
|
Szczepankiewicz A., 2014 |
|
rs7297582 |
CACNA1C
|
2(0/1/1) |
1
|
Meta analysis:P-value = 3.4E-08
Meta analysis:P-value = 3.4E-08
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Liu, Y.,2011 |
|
rs2267015 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value = 0.023, OR=1.3
Allelic association:for MDD, P-value = 0.023, OR=1.3
|
Significant associations were found in MDD.
Significant associations were found in MDD.
|
Positive
|
Hashimoto, R.,2005(a) |
|
rs6295 |
HTR1A
|
2(2/0/0) |
1
|
Meta analysis:MDD: P (allele model) = 0.006, P (recessive m......
Meta analysis:MDD: P (allele model) = 0.006, P (recessive model) = 0.01
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Kishi, T.,2012(a) |
|
rs1653625 |
P2RX7
|
2(1/0/1) |
1
|
P-value>0.05
P-value>0.05
|
The case-control analyses did not show any significant diff......
The case-control analyses did not show any significant difference in the genotype distributions of the two investigated P2RX7 polymorphisms (i.e.,rs2230912 and rs1653625) between the MDD or the BPD and the control groups.
More...
|
Negative
|
Halmai Z, 2013 |
|
rs2129575 |
TPH2
|
2(0/0/2) |
1
|
|
rs13025524 |
NPAS2
|
2(1/0/1) |
1
|
X2-tests:allele P-value = 0.017, Model Recessive......
X2-tests:allele P-value = 0.017, Model Recessive, genotype P-value = 0.004, OR(95%CI)=0.52 (0.33-0.83)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs716934 |
DGKH
|
2(0/0/2) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs131690 |
BCR
|
2(1/0/1) |
1
|
Allelic association:for MDD, P-value > 0.05
Allelic association:for MDD, P-value > 0.05
|
No significant associations were found in MDD.
No significant associations were found in MDD.
|
Negative
|
Hashimoto, R.,2005(a) |
|
rs2075507 |
COMT
TXNRD2
|
2(0/0/2) |
1
|
For MD:allele, X2=0.05, P-value = 0.81, genotype......
For MD:allele, X2=0.05, P-value = 0.81, genotype, X2=2.43, P-value = 0.29;eraly onset:allele, X2=0.99, P-value = 0.75, genotype, X2=0.63, P-value = 0.72
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Massat, I.,2011 |
|
rs686050 |
NCAM1
|
2(1/0/1) |
1
|
Fisher's exact test genotypic P-value = 0.45 , allelic P-va......
Fisher's exact test genotypic P-value = 0.45 , allelic P-value = 0.48
More...
|
For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...
|
Negative
|
Arai, M., 2004 |
|
rs4131348 |
TBC1D15
TPH2
|
2(1/0/1) |
1
|
|
rs591874 |
P2RX7
|
2(0/0/2) |
1
|
For MDD, allele, P-value = 0.0053;For Mood, allele, P-value......
For MDD, allele, P-value = 0.0053;For Mood, allele, P-value = 0.0103, OR=0.8096, P-value(perm)=0.402
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soronen, P.,2011 |
|
rs3749474 |
CLOCK
TMEM165
|
2(0/0/2) |
2
|
For MDD:Allele T, unadjusted analyses, OR=0.938, 95%CI=0.72......
For MDD:Allele T, unadjusted analyses, OR=0.938, 95%CI=0.724-1.22, P-value = 0.63;adjusted analyses, OR=0.937, 95%CI=0.723-1.22, P-value = 0.626. Recessive:genotype TT and TC, unadjusted analyses, OR=1.35, 95%CI=0.828-2.14, P-value = 0.21;adjusted analyses, OR=1.33, 95%CI=0.816-2.11, P-value = 0.233 .Dominant:genotype TT, unadjusted analyses, OR=0.958, 95%CI=0.667-1.38, P-value = 0.817;adjusted analyses, OR=0.922, 95%CI=0.641-1.34, P-value = 0.665. Co-dominant:genotype TT, unadjusted analyses, OR=1.06, 95%CI=0.609-1.77, P-value = 0.821;adjusted analyses, OR=1.01, 95%CI=0.607-1.68, P-value = 0.972;Co-dominant:genotype TC, unadjusted analyses, OR=1.4, 95%CI=0.851-2.32, P-value = 0.185;adjusted analyses, OR=1.45, 95%CI=0.874-2.40, P-value = 0.152
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Kishi, T.,2011(c) |
chi-square test: 1.total samples:P-value = 0.793(Genotype),......
chi-square test: 1.total samples:P-value = 0.793(Genotype), P-value = 0.547(Allele) in MDD 2. male samples: P-value = 0.540(Genotype), P-value = 0.409(Allele) in MDD 3. female samples: P-value = 0.822(Genotype), P-value = 0.925(Allele) in MDD
More...
|
We did not find an association between these tag SNPs and J......
We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses.
More...
|
Negative
|
Kishi, T.,2009(a) |
|
rs11123857 |
NPAS2
|
2(1/0/1) |
1
|
X2-tests:allele P-value = 2E-04, Model Log-addit......
X2-tests:allele P-value = 2E-04, Model Log-additive, genotype P-value = 7.4E-04, OR(95%CI)=1.51 (1.19-1.92)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs1170098 |
DGKH
|
2(0/0/2) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs11048994 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.156, Model Codominan......
X2-tests:allele P-value = 0.156, Model Codominant, genotype P-value = 0.014, OR(95%CI)=0.65 (0.47-0.90)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs11921360 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.097, dominant P-value = 0.038, recessive P-value = 0.223, additive P-value = 0.033, all P-value > 0.05 after multiple testing correction.
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs2279020 |
GABRA1
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = 0.55, allele P-valu......
Association analysis:genotype P-value = 0.55, allele P-value = 0.58
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Horiuchi, Y.,2004 |
|
rs4640029 |
MTERFD3
CRY1
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.295, Model Dominant,......
X2-tests:allele P-value = 0.295, Model Dominant, genotype P-value = 0.048, OR(95%CI)=1.40 (1.00-1.95)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs2336149 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.01088, OR=0.9443 for MDD, P-value=0.00000004847, ......
P-value=0.01088, OR=0.9443 for MDD, P-value=0.00000004847, OR=0.9127 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.14.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs1701946 |
KLK8
KLK9
|
1(1/0/0) |
1
|
Genotype frequency (df=2) X2=0.33, P value=0.85 ......
Genotype frequency (df=2) X2=0.33, P value=0.85 . Allele frequency (df=1) X2=0.21, P value=0.65 in Patients with MD vs controls.
More...
|
There was no significant difference in genotype or allele d......
There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression.
More...
|
Negative
|
Izumi, A., 2008 |
|
rs5746826 |
TBX1
GNB1L
|
1(0/0/1) |
1
|
X2= 0.005, P-value = 0.943 for affective disord......
X2= 0.005, P-value = 0.943 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs10207288 |
ERBB4
|
1(0/0/1) |
1
|
Chi square test: allele P-value = 0.578, OR=0.946;genotype ......
Chi square test: allele P-value = 0.578, OR=0.946;genotype P-value = 0.796, chi square=0.455 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Chen, P.,2012 |
|
rs672607 |
BCL9
|
1(1/0/0) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.001, OR(95%CI)=0.79(0.69-0.90)
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, J.,2011(b) |
|
rs2117713 |
NPAS2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.01, Model Log-additi......
X2-tests:allele P-value = 0.01, Model Log-additive, genotype P-value = 0.006, OR(95%CI)=1.51 (1.13-2.01)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs3744805 |
NR1D1
THRA
|
1(0/0/1) |
1
|
Hardy-Weinberg equilibrium P value=0.783, genotypic P value......
Hardy-Weinberg equilibrium P value=0.783, genotypic P value=0.833, allelic P value=0.768 for MDD.
More...
|
No significant association was found with major depressive ......
No significant association was found with major depressive disorder.
More...
|
Negative
|
Kishi, T., 2008 (b) |
|
rs16949856 |
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value = 0.0000362, best-fit model is De......
Omnibus GWAS Test:P-value = 0.0000362, best-fit model is Depressive disorders
More...
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Huang, J.,2010 |
|
rs7748266 |
FKBP5
|
1(0/0/1) |
1
|
P-value=0.347
P-value=0.347
|
association analysis for single polymorphisms within FKBP5 ......
association analysis for single polymorphisms within FKBP5 gene
More...
|
Negative
|
Szczepankiewicz A., 2014 |
|
rs671056 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.78, OR(95%CI)=1.03(0.81-1.03)
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(b) |
|
rs3746684 |
PROKR2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.821(Genotype),......
chi-square test: 1.total samples:P-value = 0.821(Genotype), P-value = 0.600(Allele) in MDD 2. male samples: P-value = 0.277(Genotype), P-value = 0.133(Allele) in MDD 3. female samples: P-value = 0.732(Genotype), P-value = 0.420(Allele) in MDD
More...
|
We did not detect any significant association with MDD or B......
We did not detect any significant association with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs1148247 |
CREM
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs3890379 |
CSNK1E
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.14,P-value = 0.69,OR = 0.96
Chi square test:MAF = 0.14,P-value = 0.69,OR = 0.96
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs3752826 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.1[0.97-1.24], P-value = 0.1254,......
For MDD:allele, OR[95%CI]=1.1[0.97-1.24], P-value = 0.1254, P-permutation=0.7886;genotype, P-value = 0.29907, P-permutation=0.9841
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs34041110 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.14[1.01-1.29], P-value = 0.0284......
For MDD:allele, OR[95%CI]=1.14[1.01-1.29], P-value = 0.02843, P-permutation=0.3244;genotype, P-value = 0.06655, P-permutation=0.5703
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs10807187 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.8324, OR[95%CI]=1.0......
Single SNP analyses:allele, P-value = 0.8324, OR[95%CI]=1.0137[0.8937, 1.1498], genotype, P-value = 0.8088 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs17500692 |
ADCYAP1
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.038, Model Dominant,......
X2-tests:allele P-value = 0.038, Model Dominant, genotype P-value = 0.021, OR(95%CI)=0.67 (0.47-0.94)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs4774370 |
RORA
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs9558575 |
DAOA
DAOA-AS1
|
1(0/0/1) |
1
|
Armitage's trend test:P-value = 0.95
Armitage's trend test:P-value = 0.95
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Gawlik, M.,2010 |
|
rs3738398 |
DISC1
|
1(0/0/1) |
1
|
Genotypic P-value = 0.27, allelic P-value = 1.00
Genotypic P-value = 0.27, allelic P-value = 1.00
|
no significant differences between unipolar disorder and co......
no significant differences between unipolar disorder and controls
More...
|
Negative
|
Arai, M., 2007 |
|
rs2131431 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.04[0.90-1.20], P-value = 0.5817......
For MDD:allele, OR[95%CI]=1.04[0.90-1.20], P-value = 0.58175, P-permutation=0.9999;genotype, P-value = 0.59049, P-permutation=0.9999
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs2070040 |
HTR2A
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.675(Genotype),......
chi-square test: 1.total samples:P-value = 0.675(Genotype), P-value = 0.394(Allele) in Mood disorders;P-value = 0.884(Genotype), P-value = 0.684(Allele) in MDD 2. male samples: P-value = 0.339(Genotype), P-value = 0.158(Allele) in Mood disorders;P-value = 0.456(Genotype), P-value = 0.214(Allele) in MDD 3. female samples: P-value = 0.982(Genotype), P-value = 0.851(Allele) in Mood disorders;P-value = 0.8182(Genotype), P-value = 0.526(Allele) in MDD
More...
|
we did not detect any significant association of HTR2A with......
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(b) |
|
rs4131347 |
TBC1D15
TPH2
|
1(0/0/1) |
1
|
Genotypic P-value = 0.684, allelic P-value = 0.502 for MDD ......
Genotypic P-value = 0.684, allelic P-value = 0.502 for MDD when compared with controls.
More...
|
There were no differences between MDD and healthy volunteer......
There were no differences between MDD and healthy volunteers in genotype or allelic frequency.
More...
|
Negative
|
Mann, J. J., 2008 |
|
rs4842318 |
PAWR
|
1(0/0/1) |
1
|
Hardy-Weinberg equilibrium P value=0.897, genotypic P value......
Hardy-Weinberg equilibrium P value=0.897, genotypic P value=0.726, allelic P value=0.439 for MDD compared with controls.
More...
|
No association was detected with schizophrenia or MDD in al......
No association was detected with schizophrenia or MDD in allele/genotype-wise analyses.
More...
|
Negative
|
Kishi, T., 2008 (a) |
|
rs4963954 |
BHLHE41
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs129974 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs11130317 |
GLT8D1
GNL3
SNORD69
|
1(1/0/0) |
1
|
P-value=0.007697, OR=0.9415 for MDD, P-value=0.00000004832,......
P-value=0.007697, OR=0.9415 for MDD, P-value=0.00000004832, OR=0.912 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.13.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs7431209 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.076, dominant P-value = 0.048, recessive P-value = 0.594, additive P-value = 0.159, all P-value > 0.05 after multiple testing correction.
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs3654 |
NTRK2
|
1(0/0/1) |
1
|
For MDD, allele, P-value = 0.054;For Mood, allele, P-value ......
For MDD, allele, P-value = 0.054;For Mood, allele, P-value = 0.0425, OR=1.397, P-value(perm)=0.836
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soronen, P.,2011 |
|
rs17005769 |
PAWR
|
1(0/0/1) |
1
|
Hardy-Weinberg equilibrium P value=0.313, genotypic P value......
Hardy-Weinberg equilibrium P value=0.313, genotypic P value=0.21, allelic P value=0.261 for MDD compared with controls.
More...
|
No association was detected with schizophrenia or MDD in al......
No association was detected with schizophrenia or MDD in allele/genotype-wise analyses.
More...
|
Negative
|
Kishi, T., 2008 (a) |
|
rs2239316 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs7090018 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.944, Permutated P-v......
Allelic association results:P-value = 0.944, Permutated P-value = 1
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs1374913 |
PROK2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.875(Genotype),......
chi-square test: 1.total samples:P-value = 0.875(Genotype), P-value = 0.823(Allele) in MDD 2. male samples: P-value = 0.572(Genotype), P-value = 0.554(Allele) in MDD 3. female samples: P-value = 0.592(Genotype), P-value = 0.305(Allele) in MDD
More...
|
We did not detect any significant association with MDD or B......
We did not detect any significant association with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs17014011 |
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs3829773 |
CSNK1D
SLC16A3
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.07,P-value = 0.39,OR = 0.87
Chi square test:MAF = 0.07,P-value = 0.39,OR = 0.87
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs2070062 |
CLOCK
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs4726220 |
ACTR3B
|
1(0/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs2241802 |
FZD3
RNA5SP259
|
1(0/0/1) |
1
|
Allelic association:P-value = 0.96 for MDD
Allelic association:P-value = 0.96 for MDD
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Hashimoto, R.,2005(b) |
|
rs11130315 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.007335, OR=1.063 for MDD, P-value=0.00000003019, ......
P-value=0.007335, OR=1.063 for MDD, P-value=0.00000003019, OR=1.098 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.7.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs4851392 |
NPAS2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs16840252 |
CTLA4
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=0.9253[0.7769-1.1021], P-value = ......
For MDD:allele, OR[95%CI]=0.9253[0.7769-1.1021], P-value = 0.3841, P-permutation=0.9537;genotype, P-value = 0.3011, P-permutation=0.8963
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(a) |
|
rs11927974 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.389, dominant P-value = 0.975, recessive P-value = 0.172, additive P-value = 0.909
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs738149 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=1.315,......
Single site association analysis:for MDD, allele, OR=1.315, P-value = 0.001
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Chen, P.,2011 |
|
rs1532976 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.11[0.99-1.25], P-value = 0.0806......
For MDD:allele, OR[95%CI]=1.11[0.99-1.25], P-value = 0.08061, P-permutation=0.6353;genotype, P-value = 0.2204, P-permutation=0.9506
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs7326068 |
IFT88
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value = 0.00000292, best-fit model is D......
Omnibus GWAS Test:P-value = 0.00000292, best-fit model is Depressive disorders
More...
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Huang, J.,2010 |
|
rs2463169 |
PAWR
|
1(0/0/1) |
1
|
Hardy-Weinberg equilibrium P value=0.225, genotypic P value......
Hardy-Weinberg equilibrium P value=0.225, genotypic P value=0.402, allelic P value=0.608 for MDD compared with controls.
More...
|
No association was detected with schizophrenia or MDD in al......
No association was detected with schizophrenia or MDD in allele/genotype-wise analyses.
More...
|
Negative
|
Kishi, T., 2008 (a) |
|
rs135764 |
CSNK1E
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.17,P-value = 0.48,OR = 1.08
Chi square test:MAF = 0.17,P-value = 0.48,OR = 1.08
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs1001021 |
MYO18B
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs3087243 |
CTLA4
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=0.9668[0.8323-1.1231], P-value = ......
For MDD:allele, OR[95%CI]=0.9668[0.8323-1.1231], P-value = 0.6588, P-permutation=0.9996;genotype, P-value = 0.5772, P-permutation=0.9972
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(a) |
|
rs6900617 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.1106, OR[95%CI]=1.1......
Single SNP analyses:allele, P-value = 0.1106, OR[95%CI]=1.1083[0.9768, 1.2575], genotype, P-value = 0.2453 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs2871042 |
TBX1
|
1(0/0/1) |
1
|
X2= 0.033, P-value = 0.856 for affective disord......
X2= 0.033, P-value = 0.856 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs2238777 |
TBX1
|
1(0/0/1) |
1
|
X2= 0.198, P-value = 0.657 for affective disord......
X2= 0.198, P-value = 0.657 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs231775 |
CTLA4
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.0616[0.9359-1.2043], P-value = ......
For MDD:allele, OR[95%CI]=1.0616[0.9359-1.2043], P-value = 0.3525, P-permutation=0.9371;genotype, P-value = 0.115, P-permutation=0.5522
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(a) |
|
rs4912138 |
HTR6
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = 0.894, allele P-val......
Association analysis:genotype P-value = 0.894, allele P-value = 0.938
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Fukuo, Y.,2010 |
|
rs9659997 |
HTR6
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = 0.65, allele P-valu......
Association analysis:genotype P-value = 0.65, allele P-value = 0.966
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Fukuo, Y.,2010 |
|
rs17102287 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.346, Permutated P-v......
Allelic association results:P-value = 0.346, Permutated P-value = 0.985
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs946903 |
BCL9
ACP6
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.006, OR(95%CI)=0.82(0.71-0.95)
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, J.,2011(b) |
|
rs2540352 |
VIPR2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.035, Model Dominant,......
X2-tests:allele P-value = 0.035, Model Dominant, genotype P-value = 0.023, OR(95%CI)=0.67 (0.48-0.95)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs7611731 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.01077, OR=1.059 for MDD, P-value=0.00000004995, O......
P-value=0.01077, OR=1.059 for MDD, P-value=0.00000004995, OR=1.096 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.15.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs804831 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.6245, OR[95%CI]=1.0......
Single SNP analyses:allele, P-value = 0.6245, OR[95%CI]=1.0412[0.8858, 1.2239], genotype, P-value = 0.7732 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs885861 |
VIPR2
LINC00689
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.009, Model Recessive......
X2-tests:allele P-value = 0.009, Model Recessive, genotype P-value = 0.004, OR(95%CI)=1.71 (1.18-2.46)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs4140862 |
ANO2
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs11191454 |
AS3MT
|
1(1/0/0) |
1
|
Association analysis:P-value = 0.0000000139,OR(95%CI) = 1.1......
Association analysis:P-value = 0.0000000139,OR(95%CI) = 1.13(1.08–1.18) when five disorders were combined
More...
|
Significant association was observed in cross-disorder anal......
Significant association was observed in cross-disorder analysis.
More...
|
Positive
|
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 |
|
rs909486 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=1.17, ......
Single site association analysis:for MDD, allele, OR=1.17, P-value = 0.026
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Chen, P.,2011 |
|
rs11048995 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs231777 |
CTLA4
|
1(1/0/0) |
1
|
For MDD:allele, OR[95%CI]=0.8736[0.7334-1.0405], P-value = ......
For MDD:allele, OR[95%CI]=0.8736[0.7334-1.0405], P-value = 0.1295, P-permutation=0.5924;genotype, P-value = 0.2679, P-permutation=0.8568
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(a) |
|
rs529386 |
GPR50-AS1
MIR4330
GPR50
|
1(0/0/1) |
1
|
X2 goodness of fit test:P-value > 0.05
X2 goodness of fit test:P-value > 0.05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Macintyre, D. J.,2010 |
|
rs1051375 |
CACNA1C
CACNA1C-AS1
|
1(1/0/0) |
1
|
genotypic P-value=0.71, X2=0.68, allelic P-value......
genotypic P-value=0.71, X2=0.68, allelic P-value=0.70, OR(95%CI)=0.97(0.83-1.14)
More...
|
Neither allele nor genotype frequencies of the three SNPs w......
Neither allele nor genotype frequencies of the three SNPs were significantly different between MDD patients and control subjects.
More...
|
Negative
|
Zhang X, 2013 |
|
rs1316780 |
PROK2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.527(Genotype),......
chi-square test: 1.total samples:P-value = 0.527(Genotype), P-value = 0.962(Allele) in MDD 2. male samples: P-value = 0.757(Genotype), P-value = 0.947(Allele) in MDD 3. female samples: P-value = 0.697(Genotype), P-value = 0.870(Allele) in MDD
More...
|
We did not detect any significant association with MDD or B......
We did not detect any significant association with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs1561337 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.006834, OR=0.9404 for MDD, P-value=0.0000000283, ......
P-value=0.006834, OR=0.9404 for MDD, P-value=0.0000000283, OR=0.9103 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.4.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs33967311 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.007529, OR=0.9413 for MDD, P-value=0.00000002789,......
P-value=0.007529, OR=0.9413 for MDD, P-value=0.00000002789, OR=0.9105 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.3.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs2287161 |
CRY1
MTERFD3
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs130021 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs11610949 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.043, Model Log-addit......
X2-tests:allele P-value = 0.043, Model Log-additive, genotype P-value = 0.018, OR(95%CI)=0.65 (0.46-0.94)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs1883901 |
MDGA1
|
1(1/0/0) |
1
|
Single SNP analyses:allele, P-value = 0.0463(0.4825), OR[95......
Single SNP analyses:allele, P-value = 0.0463(0.4825), OR[95%CI]=1.1676[1.0025, 1.3599], genotype, P-value = 0.1073 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs714359 |
MTERFD3
CRY1
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.032, Model Dominant,......
X2-tests:allele P-value = 0.032, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.70 (0.51-0.95)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs12487957 |
GRM2
|
1(0/0/1) |
1
|
For MDD:Genotypic association:P-value = 0.579, allelic asso......
For MDD:Genotypic association:P-value = 0.579, allelic association:P-value = 0.91
More...
|
No significant association was observed
No significant association was observed
|
Negative
|
Tsunoka, T.,2009 |
|
rs9394309 |
FKBP5
|
1(0/0/1) |
1
|
P-value=0.018
P-value=0.018
|
Our main finding is an association of FKBP5 polymorphisms (......
Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.
More...
|
Positive
|
Szczepankiewicz A., 2014 |
|
rs5748425 |
TBX1
GNB1L
|
1(0/0/1) |
1
|
For MDD, chi square test:allele P-value = 0.9845
For MDD, chi square test:allele P-value = 0.9845
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, Y.,2011 |
|
rs7280842 |
SAMSN1
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs12487591 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.006943, OR=1.063 for MDD, P-value=0.00000003091, ......
P-value=0.006943, OR=1.063 for MDD, P-value=0.00000003091, OR=1.098 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.9.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs747226 |
TBX1
|
1(0/0/1) |
1
|
X2= 0.191, P-value = 0.662 for affective disord......
X2= 0.191, P-value = 0.662 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs9326555 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.99, OR(95%CI)=1.00(0.81-1.23)
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(b) |
|
rs9533042 |
DGKH
|
1(0/0/1) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs839523 |
ERBB4
|
1(0/0/1) |
1
|
Chi square test: allele P-value = 0.555, OR=1.037;genotype ......
Chi square test: allele P-value = 0.555, OR=1.037;genotype P-value = 0.837, chi square=0.357 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Chen, P.,2012 |
|
rs130005 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs3821829 |
GRM2
TEX264
|
1(0/0/1) |
1
|
For MDD:Genotypic association:P-value = 0.869, allelic asso......
For MDD:Genotypic association:P-value = 0.869, allelic association:P-value = 0.924
More...
|
No significant association was observed
No significant association was observed
|
Negative
|
Tsunoka, T.,2009 |
|
rs352203 |
FZD3
|
1(0/0/1) |
1
|
Allelic association:P-value = 0.64 for MDD
Allelic association:P-value = 0.64 for MDD
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Hashimoto, R.,2005(b) |
|
rs12133766 |
DISC1
|
1(0/0/1) |
1
|
genotypic/allelic test P-value: 0.69/0.60
genotypic/allelic test P-value: 0.69/0.60
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs194487 |
CTNND2
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs4765914 |
CACNA1C
|
1(1/0/0) |
1
|
|
rs2371276 |
ERBB4
|
1(0/0/1) |
1
|
Chi square test: allele P-value = 0.062, OR=1.174;genotype ......
Chi square test: allele P-value = 0.062, OR=1.174;genotype P-value = 0.176, chi square=3.472 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Chen, P.,2012 |
|
rs7769372 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.8802, OR[95%CI]=0.9......
Single SNP analyses:allele, P-value = 0.8802, OR[95%CI]=0.9904[0.8732, 1.1232], genotype, P-value = 0.9888 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs2981578 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.661, Permutated P-v......
Allelic association results:P-value = 0.661, Permutated P-value = 1
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs12496634 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.007207, OR=1.063 for MDD, P-value=0.00000003439, ......
P-value=0.007207, OR=1.063 for MDD, P-value=0.00000003439, OR=1.098 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.12.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs11133379 |
CLOCK
TMEM165
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.167, Model Recessive......
X2-tests:allele P-value = 0.167, Model Recessive, genotype P-value = 0.046, OR(95%CI)=1.53 (1.01-2.32)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs2268026 |
NEK4
|
1(1/0/0) |
1
|
P-value=0.007732, OR=1.063 for MDD, P-value=0.00000003412, ......
P-value=0.007732, OR=1.063 for MDD, P-value=0.00000003412, OR=1.099 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.11.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs231779 |
CTLA4
|
1(1/0/0) |
1
|
For MDD:allele, OR[95%CI]=1.2515[1.1015-1.4218], P-value = ......
For MDD:allele, OR[95%CI]=1.2515[1.1015-1.4218], P-value = 0.0006, P-permutation=0.001;genotype, P-value = 0.0026, P-permutation=0.0201
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Liu, J,2011(a) |
|
rs5746832 |
TBX1
GNB1L
|
1(1/0/0) |
1
|
For MDD, chi square test:allele P-value = 0.0137
For MDD, chi square test:allele P-value = 0.0137
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, Y.,2011 |
|
rs7678609 |
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs1541187 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.04, OR(95%CI)=1.23(1.01-1.52)
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, J.,2011(b) |
|
rs12670064 |
VIPR2
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.157, Model Dominant,......
X2-tests:allele P-value = 0.157, Model Dominant, genotype P-value = 0.044, OR(95%CI)=0.73 (0.53-0.99)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs17101921 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.675, Permutated P-v......
Allelic association results:P-value = 0.675, Permutated P-value = 1
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs278865 |
NR4A2
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs135745 |
CSNK1E
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.21,P-value = 0.08,OR = 0.85
Chi square test:MAF = 0.21,P-value = 0.08,OR = 0.85
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs3732360 |
GSK3B
NR1I2
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.515, dominant P-value = 0.25, recessive P-value = 0.765, additive P-value = 0.302
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs2289250 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.007089, OR=0.9408 for MDD, P-value=0.00000002893,......
P-value=0.007089, OR=0.9408 for MDD, P-value=0.00000002893, OR=0.9106 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.5.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs1801117 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=0.994,......
Single site association analysis:for MDD, allele, OR=0.994, P-value = 0.964
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Chen, P.,2011 |
|
rs11875674 |
TXNL1
|
1(0/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs4633 |
COMT
|
1(0/0/1) |
1
|
For MD:allele, X2=1.86, P-value = 0.17, genotype......
For MD:allele, X2=1.86, P-value = 0.17, genotype, X2=3.57, P-value = 0.17;eraly onset:allele, X2=0.99, P-value = 0.31, genotype, X2=1.35, P-value = 0.5
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Massat, I.,2011 |
|
rs2981427 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.116, Permutated P-v......
Allelic association results:P-value = 0.116, Permutated P-value = 0.711
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs11030102 |
BDNF
BDNF-AS
|
1(0/0/1) |
1
|
For MDD, allele, P-value = 0.0516;For Mood, allele, P-value......
For MDD, allele, P-value = 0.0516;For Mood, allele, P-value = 0.0249, OR=0.8134, P-value(perm)=0.703
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soronen, P.,2011 |
|
rs11121029 |
PER3
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.769, Model Recessive......
X2-tests:allele P-value = 0.769, Model Recessive, genotype P-value = 0.047, OR(95%CI)=0.43 (0.18-1.04)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs4964060 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs2075984 |
CSNK1E
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.45,P-value = 0.36,OR = 0.93
Chi square test:MAF = 0.45,P-value = 0.36,OR = 0.93
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs1873827 |
YWHAE
|
1(1/0/0) |
1
|
For MDD:allele, OR[95%CI]=0.93[0.89-1.051, P-value = 0.9368......
For MDD:allele, OR[95%CI]=0.93[0.89-1.051, P-value = 0.93684, P-permutation=0.9597;genotype, P-value = 0.41119, P-permutation=0.9974
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs17083008 |
VIP
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs2284031 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=0.801,......
Single site association analysis:for MDD, allele, OR=0.801, P-value = 0.006
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Chen, P.,2011 |
|
rs4982029 |
NPAS3
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs1612902 |
KLK8
|
1(1/0/0) |
1
|
Genotype frequency (df=2) X2=0.56, P value=0.75 ......
Genotype frequency (df=2) X2=0.56, P value=0.75 . Allele frequency (df=1) X2=0.56, P value=0.45 in Patients with MD vs controls.
More...
|
There was no significant difference in genotype or allele d......
There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression.
More...
|
Negative
|
Izumi, A., 2008 |
|
rs6740584 |
CREB1
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs3796224 |
PROK2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.832(Genotype),......
chi-square test: 1.total samples:P-value = 0.832(Genotype), P-value = 0.556(Allele) in MDD 2. male samples: P-value = 0.768(Genotype), P-value = 0.514(Allele) in MDD 3. female samples: P-value = 0.995(Genotype), P-value = 0.916(Allele) in MDD
More...
|
We did not detect any significant association with MDD or B......
We did not detect any significant association with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs2254298 |
OXTR
CAV3
|
1(0/0/1) |
1
|
Chi-squared test:genotype, P-value = 0.035;allele A-carrier......
Chi-squared test:genotype, P-value = 0.035;allele A-carriers vs. GG, OR(95%CI)=0.55(0.31-0.98), P-value = 0.04
More...
|
Significant association was found in MDD.
Significant association was found in MDD.
|
Positive
|
Costa, B.,2009 |
|
rs4818 |
COMT
|
1(0/0/1) |
1
|
For MD:allele, X2=1.71, P-value = 0.18, genotype......
For MD:allele, X2=1.71, P-value = 0.18, genotype, X2=2.72, P-value = 0.25;eraly onset:allele, X2=2.12, P-value = 0.14, genotype, X2=2.42, P-value = 0.29
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Massat, I.,2011 |
|
rs4821565 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=1.051,......
Single site association analysis:for MDD, allele, OR=1.051, P-value = 0.417
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Chen, P.,2011 |
|
rs734312 |
WFS1
|
1(0/0/1) |
1
|
patients with MDD (R vs. H: OR=0.95, 95% CI=0.70-1.28, P-va......
patients with MDD (R vs. H: OR=0.95, 95% CI=0.70-1.28, P-value=0.73; HR+RR vs. HH: OR= 1.01, 95% CI=0.61-1.67, P-value=0.97; RR vs. HH+HR: OR=0.79, 95% CI=0.59-1.07, P-value=0.13; RR vs. HH: OR=0.84, 95% CI=0.59-1.20, P-value=0.34; HR vs. HH: OR=1.07, 95% CI=0.64-1.78, P-value=0.60).
More...
|
No significant associations were observed.
No significant associations were observed.
|
Negative
|
Tang, X. W., 2014 |
|
rs7581886 |
NPAS2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs3790757 |
HTR6
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = 0.479, allele P-val......
Association analysis:genotype P-value = 0.479, allele P-value = 0.366
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Fukuo, Y.,2010 |
|
rs2304673 |
PER2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.076, Model Dominant,......
X2-tests:allele P-value = 0.076, Model Dominant, genotype P-value = 0.049, OR(95%CI)=1.39 (1.00-1.94)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs3754674 |
NPAS2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.097, Model Recessive......
X2-tests:allele P-value = 0.097, Model Recessive, genotype P-value = 0.016, OR(95%CI)=0.62 (0.41-0.92)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs1240083 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.63, OR(95%CI)=0.96(0.82-1.13)
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(b) |
|
rs11022778 |
ARNTL
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.125, Model Recessive......
X2-tests:allele P-value = 0.125, Model Recessive, genotype P-value = 0.022, OR(95%CI)=1.67 (1.08-2.58)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs11541353 |
NPAS2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.009, Model Log-addit......
X2-tests:allele P-value = 0.009, Model Log-additive, genotype P-value = 0.028, OR(95%CI)=1.35 (1.03-1.76)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs9462341 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.0303(0.0902), OR[95......
Single SNP analyses:allele, P-value = 0.0303(0.0902), OR[95%CI]=0.8748[0.7751, 0.9874], genotype, P-value = 0.082 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs16935888 |
CREM
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs5748427 |
TBX1
GNB1L
|
1(1/0/0) |
1
|
For MDD, chi square test:allele P-value = 0.0304
For MDD, chi square test:allele P-value = 0.0304
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, Y.,2011 |
|
rs1722550 |
KLK8
KLK9
|
1(1/0/0) |
1
|
Genotype frequency (df=2) X2=0.5, P value=0.78 .......
Genotype frequency (df=2) X2=0.5, P value=0.78 . Allele frequency (df=1) X2=0.58, P value=0.47 in Patients with MD vs controls.
More...
|
There was no significant difference in genotype or allele d......
There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression.
More...
|
Negative
|
Izumi, A., 2008 |
|
rs2236570 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.78, OR(95%CI)=1.02(0.89-1.16)
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(b) |
|
rs8064578 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.05[0.94-1.19], P-value = 0.3885......
For MDD:allele, OR[95%CI]=1.05[0.94-1.19], P-value = 0.38858, P-permutation=0.9966;genotype, P-value = 0.69385, P-permutation=1
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs960914 |
FZD3
MIR4288
|
1(0/0/1) |
1
|
Allelic association:P-value = 0.61 for MDD
Allelic association:P-value = 0.61 for MDD
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Hashimoto, R.,2005(b) |
|
rs989713 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.0748, OR[95%CI]=1.1......
Single SNP analyses:allele, P-value = 0.0748, OR[95%CI]=1.1775[0.9837, 1.4094], genotype, P-value = 0.1617 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs2072707 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=0.919,......
Single site association analysis:for MDD, allele, OR=0.919, P-value = 0.364
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Chen, P.,2011 |
|
rs1170099 |
DGKH
|
1(0/0/1) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs3766512 |
BCL9
ACP6
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.13, OR(95%CI)=1.10(0.97-1.24)
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(b) |
|
rs3783641 |
GCH1
|
1(0/0/1) |
1
|
chi-square test:Allele:,unadjusted OR = 1,95%CI = 0.831–1......
chi-square test:Allele:,unadjusted OR = 1,95%CI = 0.831–1.20,P-value = 0.999;adjusted OR = 1,95%CI = 0.831–1.20,P-value = 0.999;Dominant:,unadjusted OR = 0.961,95%CI = 0.768–1.20,P-value = 0.724;adjusted OR = 0.938,95%CI = 0.742–1.18,P-value = 0.591;Recessive:,unadjusted OR = 1.2,95%CI = 0.740–1.88,P-value = 0.44;adjusted OR = 1.17,95%CI = 0.706–1.86,P-value = 0.53;Co-dominant:TT,unadjusted OR = 0.772,95%CI = 0.424–1.47,P-value = 0.413;adjusted OR = 0.797,95%CI = 0.428–1.56,P-value = 0.49;CC:,unadjusted OR = 1.06,95%CI = 0.721–1.53,P-value = 0.769;adjusted OR = 1.02,95%CI = 0.684–1.49,P-value = 0.932
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Kishi, T.,2012(b) |
|
rs208290 |
P2RX7
|
1(0/0/1) |
1
|
For MDD, allele, P-value = 0.0507;For Mood, allele, P-value......
For MDD, allele, P-value = 0.0507;For Mood, allele, P-value = 0.0706, OR=0.8661, P-value(perm)=0.965
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soronen, P.,2011 |
|
rs7225165 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.02[0.83-1.25], P-value = 0.8609......
For MDD:allele, OR[95%CI]=1.02[0.83-1.25], P-value = 0.86091, P-permutation=1;genotype, P-value = 0.02088, P-permutation=0.0605
More...
|
Significant association was found, but the significance was......
Significant association was found, but the significance was lost after permutation.
More...
|
Positive
|
Liu, J,2011(b) |
|
rs17721321 |
PROKR2
|
1(1/0/0) |
1
|
chi-square test: 1.total samples:P-value = 0.145(Genotype),......
chi-square test: 1.total samples:P-value = 0.145(Genotype), P-value = 0.0658(Allele) in MDD 2. male samples: P-value = 0.833(Genotype), P-value = 0.548(Allele) in MDD 3. female samples: P-value = 0.177(Genotype), P-value = 0.0907(Allele) in MDD;
More...
|
Significant association was observed only in the BP group, ......
Significant association was observed only in the BP group, not in the MDD group.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs900144 |
ARNTL
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.181, Model Dominant,......
X2-tests:allele P-value = 0.181, Model Dominant, genotype P-value = 0.023, OR(95%CI)=0.69 (0.50-0.95)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs9566940 |
DGKH
|
1(0/0/1) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs10842905 |
ARNTL2
STK38L
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs2269726 |
GNB1L
|
1(1/0/0) |
1
|
For MDD, chi square test:allele P-value = 0.1334
For MDD, chi square test:allele P-value = 0.1334
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, Y.,2011 |
|
rs6693503 |
HTR6
NBL1
MINOS1-NBL1
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = 0.977, allele P-val......
Association analysis:genotype P-value = 0.977, allele P-value = 0.904
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Fukuo, Y.,2010 |
|
rs1805054 |
HTR6
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = 0.917, allele P-val......
Association analysis:genotype P-value = 0.917, allele P-value = 0.963;meta analysis:fixed model: pooled OR= 0.943, 95%CI = 0.820-1.08, P(Z) = 0.406
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Fukuo, Y.,2010 |
|
rs16940655 |
CRHR1
MAPT-AS1
|
1(1/0/0) |
1
|
allelic P-value=0.228, genotypic P-value=0.003, OR=1.137, 9......
allelic P-value=0.228, genotypic P-value=0.003, OR=1.137, 95% CI=0.930-1.389 for affective disorder; allelic P-value=0.94, genotypic P-value=0.277, OR=1.014, 95% CI=0.755-1.362 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Szczepankiewicz, A., 2013 |
|
rs4474484 |
TPH2
|
1(0/0/1) |
1
|
|
rs215976 |
CACNA1C
|
1(0/0/1) |
1
|
genotypic P-value=0.89, X2=0.23, allelic P-value......
genotypic P-value=0.89, X2=0.23, allelic P-value=0.98, OR(95%CI)=0.98(0.83-1.16)
More...
|
Neither allele nor genotype frequencies of the three SNPs w......
Neither allele nor genotype frequencies of the three SNPs were significantly different between MDD patients and control subjects.
More...
|
Negative
|
Zhang X, 2013 |
|
rs2799573 |
CACNB2
|
1(1/0/0) |
1
|
Association analysis:P-value = 0.0000000429,OR(95%CI) = 1.0......
Association analysis:P-value = 0.0000000429,OR(95%CI) = 1.08(1.05-1.12) when five disorders were combined
More...
|
Significant association was observed in cross-disorder anal......
Significant association was observed in cross-disorder analysis.
More...
|
Positive
|
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 |
|
rs2400546 |
PAWR
|
1(0/0/1) |
1
|
Hardy-Weinberg equilibrium P value=0.408, genotypic P value......
Hardy-Weinberg equilibrium P value=0.408, genotypic P value=0.453, allelic P value=0.656 for MDD compared with controls.
More...
|
No association was detected with schizophrenia or MDD in al......
No association was detected with schizophrenia or MDD in allele/genotype-wise analyses.
More...
|
Negative
|
Kishi, T., 2008 (a) |
|
rs707284 |
ERBB4
|
1(0/0/1) |
1
|
Chi square test: allele P-value = 0.799, OR=0.984;genotype ......
Chi square test: allele P-value = 0.799, OR=0.984;genotype P-value = 0.964, chi square=0.074 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Chen, P.,2012 |
|
rs55909231 |
KLK8
KLK9
|
1(0/0/1) |
1
|
Genotype frequency (df=2) X2=4.94, P value=0.08 ......
Genotype frequency (df=2) X2=4.94, P value=0.08 . Allele frequency (df=1) X2=2.48, P value=0.12 in Patients with MD vs controls.
More...
|
There was no significant difference in genotype or allele d......
There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression.
More...
|
Negative
|
Izumi, A., 2008 |
|
rs11931061 |
CLOCK
|
1(0/0/1) |
1
|
chi-square test: 1. total samples:P-value = 0.902(Genotype)......
chi-square test: 1. total samples:P-value = 0.902(Genotype), P-value = 0.208(Allele) in MDD 2. male samples: P-value = 0.195(Genotype), P-value = 0.190(Allele) in MDD 3. female samples: P-value = 0.297(Genotype), P-value = 0.330(Allele) in MDD
More...
|
We did not find an association between these tag SNPs and J......
We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses.
More...
|
Negative
|
Kishi, T.,2009(a) |
|
rs6269 |
COMT
|
1(0/0/1) |
1
|
For MD:allele, X2=0.17, P-value = 0.67, genotype......
For MD:allele, X2=0.17, P-value = 0.67, genotype, X2=1.12, P-value = 0.56;eraly onset:allele, X2=0.06, P-value = 0.79, genotype, X2=1.44, P-value = 0.48
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Massat, I.,2011 |
|
rs10508451 |
CCDC3
OPTN
|
1(0/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs4271171 |
FAM20B
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs35878285 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs917815 |
SP8
|
1(0/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs10462028 |
CLOCK
TMEM165
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs7071307 |
PPP2R2D
|
1(0/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs1701947 |
KLK8
KLK9
|
1(0/0/1) |
1
|
Genotype frequency (df=2) X2=0.31, P value=0.86 ......
Genotype frequency (df=2) X2=0.31, P value=0.86 . Allele frequency (df=1) X2=0.21, P value=0.65 in Patients with MD vs controls.
More...
|
There was no significant difference in genotype or allele d......
There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression.
More...
|
Negative
|
Izumi, A., 2008 |
|
rs6085086 |
PROKR2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.314(Genotype),......
chi-square test: 1.total samples:P-value = 0.314(Genotype), P-value = 0.125(Allele) in MDD 2. male samples: P-value = 0.600(Genotype), P-value = 0.479(Allele) in MDD 3. female samples: P-value = 0.445(Genotype), P-value = 0.192(Allele) in MDD
More...
|
We did not detect any significant association with MDD or B......
We did not detect any significant association with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs11237798 |
TENM4
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs2117975 |
GPR176
EIF2AK4
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs2981581 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.283, Permutated P-v......
Allelic association results:P-value = 0.283, Permutated P-value = 0.963
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs17662394 |
NPAS2
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.014, Model Log-addit......
X2-tests:allele P-value = 0.014, Model Log-additive, genotype P-value = 0.022, OR(95%CI)=1.43 (1.05-1.95)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs2289247 |
GLT8D1
GNL3
SNORD19
SNORD69
SNORD19B
|
1(1/0/0) |
1
|
P-value = 8.96E-7 for a meta-analysis in the GAIN-MDD sampl......
P-value = 8.96E-7 for a meta-analysis in the GAIN-MDD sample.
More...
|
It is significant in the GAIN-MDD sample.
It is significant in the GAIN-MDD sample.
|
Positive
|
McMahon, F. J., 2010 |
|
rs6001093 |
CSNK1E
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.09,P-value = 0.92,OR = 0.99
Chi square test:MAF = 0.09,P-value = 0.92,OR = 0.99
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs386551 |
SPHK2
CA11
DBP
SEC1P
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.104, Model Recessive......
X2-tests:allele P-value = 0.104, Model Recessive, genotype P-value = 0.011, OR(95%CI)=2.15 (1.18-3.93)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs11655548 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=0.94[0.83-1.07], P-value = 0.3606......
For MDD:allele, OR[95%CI]=0.94[0.83-1.07], P-value = 0.36063, P-permutation=0.9959;genotype, P-value = 0.63938, P-permutation=1
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs12452627 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=0.94[0.77-1.14], P-value = 0.5221......
For MDD:allele, OR[95%CI]=0.94[0.77-1.14], P-value = 0.52212, P-permutation=0.9996;genotype, P-value = 0.02815, P-permutation=0.322
More...
|
Significant association was found, but the significance was......
Significant association was found, but the significance was lost after permutation.
More...
|
Positive
|
Liu, J,2011(b) |
|
rs8007267 |
GCH1
|
1(0/0/1) |
1
|
chi-square test:Allele:,unadjusted OR = 0.841,95%CI = 0.698......
chi-square test:Allele:,unadjusted OR = 0.841,95%CI = 0.698–1.01,P-value = 0.0684;adjusted OR = 0.841,95%CI = 0.698–1.01,P-value = 0.0684;Dominant:,unadjusted OR = 0.814,95%CI = 0.651–1.02,P-value = 0.0702;adjusted OR = 0.814,95%CI = 0.644–1.03,P-value = 0.0823;Recessive:,unadjusted OR = 0.789,95%CI = 0.450–1.30,P-value = 0.378;adjusted OR = 0.768,95%CI = 0.428–1.30,P-value = 0.348;Co-dominant:TT,unadjusted OR = 0.717,95%CI = 0.469–1.66,P-value = 0.111;adjusted OR = 0.707,95%CI = 0.454–1.07,P-value = 0.111;CC:,unadjusted OR = 1.33,95%CI = 0.678–2.80,P-value = 0.433;adjusted OR = 1.37,95%CI = 0.681–3.00,P-value = 0.401
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Kishi, T.,2012(b) |
|
rs53576 |
OXTR
CAV3
|
1(0/0/1) |
1
|
Chi-squared test:genotype, P-value = 0.042;allele A-carrier......
Chi-squared test:genotype, P-value = 0.042;allele A-carriers vs. GG, OR(95%CI)=0.56(0.34-0.93), P-value = 0.02
More...
|
Significant association was found in MDD.
Significant association was found in MDD.
|
Positive
|
Costa, B.,2009 |
|
rs3746682 |
PROKR2
|
1(1/0/0) |
1
|
chi-square test:1.total samples:P-value = 0.169(Genotype), ......
chi-square test:1.total samples:P-value = 0.169(Genotype), P-value = 0.549(Allele) in MDD 2. male samples: P-value = 0.710(Genotype), P-value = 0.500(Allele) in MDD 3. female samples: P-value = 0.0673(Genotype), P-value = 0.0261, Corrected P-value = 0.470(Allele) in MDD
More...
|
Significant association was observed only in the BP group, ......
Significant association was observed only in the BP group, not in the MDD group.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs12539410 |
PLXNA4
CHCHD3
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value = 0.00000474, best-fit model is D......
Omnibus GWAS Test:P-value = 0.00000474, best-fit model is Depressive disorders
More...
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Huang, J.,2010 |
|
rs10865660 |
PROK2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.882(Genotype),......
chi-square test: 1.total samples:P-value = 0.882(Genotype), P-value = 0.638(Allele) in MDD 2. male samples: P-value = 0.960(Genotype), P-value = 0.954(Allele) in MDD 3. female samples: P-value = 0.793(Genotype), P-value = 0.632(Allele) in MDD
More...
|
We did not detect any significant association with MDD or B......
We did not detect any significant association with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(c) |
|
rs6481941 |
CREM
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs9392 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs334538 |
RN7SL762P
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.992, dominant P-value = 0.907, recessive P-value = 0.946, additive P-value = 0.902
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs11199993 |
FGFR2
|
1(1/0/0) |
1
|
Allelic association results:P-value = 0.018, Permutated P-v......
Allelic association results:P-value = 0.018, Permutated P-value = 0.175
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs334555 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.793, dominant P-value = 0.556, recessive P-value = 0.632, additive P-value = 0.506
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs3135730 |
FGFR2
|
1(0/0/1) |
1
|
Allelic association results:P-value = 0.214, Permutated P-v......
Allelic association results:P-value = 0.214, Permutated P-value = 0.909
More...
|
No significant association was observed in MDD
No significant association was observed in MDD
|
Negative
|
Wang, T.,2012 |
|
rs841 |
GCH1
|
1(0/0/1) |
1
|
chi-square test:Allele:,unadjusted OR = 1.03,95%CI = 0.882â......
chi-square test:Allele:,unadjusted OR = 1.03,95%CI = 0.882–1.20,P-value = 0.711;adjusted OR = 1.03,95%CI = 0.882–1.20,P-value = 0.711;Dominant:,unadjusted OR = 1,95%CI = 0.802–1.26,P-value = 0.98;adjusted OR = 0.933,95%CI = 0.740–1.18,P-value = 0.562;Recessive:,unadjusted OR = 1.1,95%CI = 0.824–1.45,P-value = 0.513;adjusted OR = 1.1,95%CI = 0.816–1.47,P-value = 0.519;Co-dominant:TT,unadjusted OR = 0.884,95%CI = 0.612–1.30,P-value = 0.523;adjusted OR = 0.887,95%CI = 0.603–1.32,P-value = 0.548;CC:,unadjusted OR = 1.04,95%CI = 0.759–1.42,P-value = 0.821;adjusted OR = 0.953,95%CI = 0.690–1.32,P-value = 0.771
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Kishi, T.,2012(b) |
|
rs2301558 |
TBX1
|
1(0/0/1) |
1
|
X2= 1.676, P-value = 0.195 for affective disord......
X2= 1.676, P-value = 0.195 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs3758354 |
ANXA1
|
1(0/1/0) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs9901910 |
CSNK1D
SLC16A3
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.29,P-value = 0.14,OR = 1.14
Chi square test:MAF = 0.29,P-value = 0.14,OR = 1.14
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs1468089 |
GNB1L
|
1(0/0/1) |
1
|
For MDD, chi square test:allele P-value = 0.731
For MDD, chi square test:allele P-value = 0.731
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, Y.,2011 |
|
rs1054190 |
GSK3B
NR1I2
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.521, dominant P-value = 0.393, recessive P-value = 0.547, additive P-value = 0.506
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs6311 |
HTR2A
|
1(0/0/1) |
1
|
Meta analysis: Allele model:Asian,OR = 0.86,95%CI = 0.67–......
Meta analysis: Allele model:Asian,OR = 0.86,95%CI = 0.67–1.09; Caucasian,OR = 1.13,95%CI = 0.80–1.59; Total,OR = 0.91,95%CI = 0.74–1.12.Dominant model:Asian,OR = 0.88,95%CI = 0.61–1.27; Caucasian,OR = 1.18,95%CI = 0.73–1.90; Total,OR = 0.96,95%CI = 0.73–1.25.Recessive model:Asian,OR = 0.84,95%CI = 0.62–1.14; Caucasian,OR = 1.14,95%CI = 0.56–2.31; Total,OR = 0.87,95%CI = 0.69–1.11.Codominant model:Asian,OR = 0.74,95%CI = 0.49–1.12; Caucasian,OR = 1.06,95%CI = 0.51–2.23; Total,OR = 0.79,95%CI = 0.56–1.11.Codominant model:Asian,OR = 0.97,95%CI = 0.75–1.25; Caucasian,OR = 1.17,95%CI = 0.71–1.92; Total,OR = 1.01,95%CI = 0.80–1.26
More...
|
The results indicated that the HTR2A 21438A/G polymorphism ......
The results indicated that the HTR2A 21438A/G polymorphism was not associated with MDD in Caucasians in all genetic models.
More...
|
Negative
|
Gu, L.,2013 |
|
rs969485 |
ARNTL
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.713, Model Codominan......
X2-tests:allele P-value = 0.713, Model Codominant, genotype P-value = 0.041, OR(95%CI)=0.75 (0.55-1.02)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs2239317 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs13064064 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.006704, OR=1.063 for MDD, P-value=0.00000003091, ......
P-value=0.006704, OR=1.063 for MDD, P-value=0.00000003091, OR=1.098 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.10.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs4687771 |
GRM2
|
1(0/0/1) |
1
|
For MDD:Genotypic association:P-value = 0.989, allelic asso......
For MDD:Genotypic association:P-value = 0.989, allelic association:P-value = 0.911
More...
|
No significant association was observed
No significant association was observed
|
Negative
|
Tsunoka, T.,2009 |
|
rs737868 |
TBX1
|
1(0/0/1) |
1
|
X2= 0.074, P-value = 0.785 for affective disord......
X2= 0.074, P-value = 0.785 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs7546310 |
DISC1
DISC1-IT1
|
1(1/0/0) |
1
|
genotypic/allelic test P-value: 0.13/0.066
genotypic/allelic test P-value: 0.13/0.066
|
No significant genotypic or allelic association was observe......
No significant genotypic or allelic association was observed.
More...
|
Negative
|
Schosser, A., 2010 |
|
rs1811017 |
BCR
RN7SL263P
FBXW4P1
|
1(0/0/1) |
1
|
Allelic association:for MDD, P-value > 0.05
Allelic association:for MDD, P-value > 0.05
|
No significant associations were found in MDD.
No significant associations were found in MDD.
|
Negative
|
Hashimoto, R.,2005(a) |
|
rs10494251 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.04, OR(95%CI)=0.86(0.75-0.99)
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, J.,2011(b) |
|
rs12458992 |
CCDC102B
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value = 0.0000359, best-fit model is De......
Omnibus GWAS Test:P-value = 0.0000359, best-fit model is Depressive disorders
More...
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Huang, J.,2010 |
|
rs2122246 |
DGKH
|
1(1/0/0) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs13068293 |
PBRM1
|
1(1/0/0) |
1
|
P-value=0.007035, OR=0.9407 for MDD, P-value=0.00000002904,......
P-value=0.007035, OR=0.9407 for MDD, P-value=0.00000002904, OR=0.9104 for combined sample
More...
|
In the combined analysis of these 819 SNPs, 15 exceeded gen......
In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.6.
More...
|
Positive
|
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 |
|
rs13394520 |
NPAS2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.23, Model Recessive,......
X2-tests:allele P-value = 0.23, Model Recessive, genotype P-value = 0.036, OR(95%CI)=1.59 (1.03-2.44)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs135757 |
CSNK1E
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.22,P-value = 0.57,OR = 0.95
Chi square test:MAF = 0.22,P-value = 0.57,OR = 0.95
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs12775799 |
CREM
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs11925868 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.811, dominant P-value = 0.572, recessive P-value = 0.845, additive P-value = 0.641
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs839511 |
ERBB4
|
1(0/0/1) |
1
|
Chi square test: allele P-value = 0.526, OR=0.938;genotype ......
Chi square test: allele P-value = 0.526, OR=0.938;genotype P-value = 0.805, chi square=0.434 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Chen, P.,2012 |
|
rs748806 |
GNB1L
|
1(1/0/0) |
1
|
For MDD, chi square test:allele P-value = 0.4638
For MDD, chi square test:allele P-value = 0.4638
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, Y.,2011 |
|
rs739374 |
TBX1
|
1(0/0/1) |
1
|
X2= 2.490, P-value = 0.115 for affective disord......
X2= 2.490, P-value = 0.115 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs4815787 |
PROKR2
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.00418, Correct......
chi-square test: 1.total samples:P-value = 0.00418, Corrected P-value = 0.0376(Genotype), P-value = 0.000684, Corrected P-value = 0.00616(Allele) in MDD 2. male samples: P-value = 0.150(Genotype), P-value = 0.0490, Corrected P-value = 0.882(Allele) in MDD 3. female samples: P-value = 0.0248, Corrected P-value = 0.446(Genotype), P-value = 0.00444, Corrected P-value = 0.0799(Allele) in MDD
More...
|
Significant association was observed only in the MDD group.
Significant association was observed only in the MDD group.
|
Positive
|
Kishi, T.,2009(c) |
|
rs11705394 |
CSF2RB
|
1(0/0/1) |
1
|
Single site association analysis:for MDD, allele, OR=1.15, ......
Single site association analysis:for MDD, allele, OR=1.15, P-value = 0.284
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Chen, P.,2011 |
|
rs9462343 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.4543, OR[95%CI]=1.0......
Single SNP analyses:allele, P-value = 0.4543, OR[95%CI]=1.0664[0.9011, 1.2620], genotype, P-value = 0.5762 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs11759115 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.5261, OR[95%CI]=0.9......
Single SNP analyses:allele, P-value = 0.5261, OR[95%CI]=0.9485[0.8054, 1.1170], genotype, P-value = 0.8089 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs4934735 |
CREM
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs3846881 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.5698, OR[95%CI]=1.0......
Single SNP analyses:allele, P-value = 0.5698, OR[95%CI]=1.0351[0.9190, 1.1658], genotype, P-value = 0.3786 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs11939815 |
CLOCK
|
1(0/0/1) |
1
|
chi-square test: 1.total samples: P-value = 0.822(Genotype)......
chi-square test: 1.total samples: P-value = 0.822(Genotype), P-value = 0.302(Allele) in MDD 2. male samples: P-value = 0.161(Genotype), P-value = 0.188(Allele) in MDD 3 female samples:P-value = 0.303(Genotype), P-value = 0.412(Allele) in MDD
More...
|
We did not find an association between these tag SNPs and J......
We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses.
More...
|
Negative
|
Kishi, T.,2009(a) |
|
rs3025702 |
CREBBP
|
1(0/0/1) |
1
|
Association analysis:genotype P-value = >0.05;allele P-valu......
Association analysis:genotype P-value = >0.05;allele P-value > 0.05
More...
|
No significant association was observed in MDD.
No significant association was observed in MDD.
|
Negative
|
Crisafulli, C.,2012 |
|
rs347387 |
DGKH
|
1(1/0/0) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs10506018 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value = 0.098, Model Codominan......
X2-tests:allele P-value = 0.098, Model Codominant, genotype P-value = 0.009, OR(95%CI)=0.63 (0.44-0.88)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs6662926 |
TSNAX
|
1(0/0/1) |
1
|
chi square test:genotype P-value = 0.27, allele P-value = 0......
chi square test:genotype P-value = 0.27, allele P-value = 0.153
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Okuda, A.,2010 |
|
rs2372008 |
CRIM1
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs11133385 |
CLOCK
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.977(Genotype),......
chi-square test: 1.total samples:P-value = 0.977(Genotype), P-value = 0.482(Allele) in MDD 2. male samples: P-value = 0.195(Genotype), P-value = 0.239(Allele) in MDD 3. female samples: P-value = 0.176(Genotype), P-value = 0.263(Allele) in MDD
More...
|
We did not find an association between these tag SNPs and J......
We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses.
More...
|
Negative
|
Kishi, T.,2009(a) |
|
rs688325 |
BCL9
|
1(0/0/1) |
1
|
Third-Stage Sample:for MDD, allele association P-value = 0.......
Third-Stage Sample:for MDD, allele association P-value = 0.02, OR(95%CI)=1.16(1.03-1.32)
More...
|
Significant association was observed in MDD.
Significant association was observed in MDD.
|
Positive
|
Li, J.,2011(b) |
|
rs10994338 |
ANK3
|
1(1/0/0) |
1
|
Meta analysis:P-value = 4.8E-07
Meta analysis:P-value = 4.8E-07
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Liu, Y.,2011 |
|
rs2267012 |
BCR
|
1(1/0/0) |
1
|
Allelic association:for MDD, P-value = 0.0097, OR=1.33
Allelic association:for MDD, P-value = 0.0097, OR=1.33
|
Significant associations were found in MDD.
Significant associations were found in MDD.
|
Positive
|
Hashimoto, R.,2005(a) |
|
rs5748432 |
GNB1L
|
1(1/0/0) |
1
|
For MDD, chi square test:allele P-value = 0.0897
For MDD, chi square test:allele P-value = 0.0897
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, Y.,2011 |
|
rs7224258 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.02[0.89-1.17], P-value = 0.8102......
For MDD:allele, OR[95%CI]=1.02[0.89-1.17], P-value = 0.81025, P-permutation=1;genotype, P-value = 0.77061, P-permutation=1
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs3793227 |
VIPR2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs9566931 |
DGKH
|
1(0/0/1) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs2970844 |
ARNTL2
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs9826659 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.377, dominant P-value = 0.373, recessive P-value = 0.427, additive P-value = 0.693
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs9532988 |
DGKH
MAPK6PS3
|
1(0/0/1) |
1
|
Allelic association:P-value > 0.05 for MDD.
Allelic association:P-value > 0.05 for MDD.
|
No significant association was observed after permutation.
No significant association was observed after permutation.
|
Negative
|
Zeng, Z.,2011 |
|
rs5742909 |
CTLA4
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=0.9529[0.7988-1.1368], P-value = ......
For MDD:allele, OR[95%CI]=0.9529[0.7988-1.1368], P-value = 0.5919, P-permutation=0.9985;genotype, P-value = 0.5693, P-permutation=0.9963
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(a) |
|
rs28365859 |
YWHAE
|
1(0/0/1) |
1
|
For MDD:allele, OR[95%CI]=1.09[0.96-1.24], P-value = 0.1890......
For MDD:allele, OR[95%CI]=1.09[0.96-1.24], P-value = 0.18902, P-permutation=0.925;genotype, P-value = 0.36552, P-permutation=0.9955
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Liu, J,2011(b) |
|
rs885988 |
TBX1
|
1(0/0/1) |
1
|
X2= 0.001, P-value = 0.971 for affective disord......
X2= 0.001, P-value = 0.971 for affective disorder (BP + MDD) when compared with controls
More...
|
None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...
|
Negative
|
Funke, B. H., 2007 |
|
rs12191311 |
MDGA1
|
1(0/0/1) |
1
|
Single SNP analyses:allele, P-value = 0.3064, OR[95%CI]=0.9......
Single SNP analyses:allele, P-value = 0.3064, OR[95%CI]=0.9333[0.8178, 1.0652], genotype, P-value = 0.5831 for MDD
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Li, J.,2011(a) |
|
rs3751222 |
ARNTL2
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.055, Model Codominan......
X2-tests:allele P-value = 0.055, Model Codominant, genotype P-value = 0.011, OR(95%CI)=0.54 (0.33-0.87)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs4789846 |
CSNK1D
|
1(0/0/1) |
1
|
Chi square test:MAF = 0.29,P-value = 0.068,OR = 1.17
Chi square test:MAF = 0.29,P-value = 0.068,OR = 1.17
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs6502097 |
SECTM1
CSNK1D
|
1(1/0/0) |
1
|
Chi square test:MAF = 0.14,P-value = 0.48,OR = 0.92
Chi square test:MAF = 0.14,P-value = 0.48,OR = 0.92
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Matsunaga, S.,2012 |
|
rs9819616 |
RBMS3
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value = 0.0000446, best-fit model is Ma......
Omnibus GWAS Test:P-value = 0.0000446, best-fit model is Major depressive disorder specifi c
More...
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Huang, J.,2010 |
|
rs13314595 |
GSK3B
|
1(0/0/1) |
1
|
association analyses with diagnosis:codominant P-value = 0.......
association analyses with diagnosis:codominant P-value = 0.899, dominant P-value = 0.923, recessive P-value = 0.68, additive P-value = 0.947
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Saus, E.,2010 |
|
rs7997012 |
HTR2A
|
1(0/0/1) |
1
|
chi-square test: 1.total samples:P-value = 0.781(Genotype),......
chi-square test: 1.total samples:P-value = 0.781(Genotype), P-value = 0.518(Allele) in Mood disorders;P-value = 0.336(Genotype), P-value = 0.149(Allele) in MDD 2. male samples: P-value = 0.317(Genotype), P-value = 0.414(Allele) in Mood disorders;P-value = 0.236(Genotype), P-value = 0.293(Allele) in MDD 3. female samples: P-value = 0.703(Genotype), P-value = 0.874(Allele) in Mood disorders;P-value = 0.374(Genotype), P-value = 0.297(Allele) in MDD
More...
|
we did not detect any significant association of HTR2A with......
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis.
More...
|
Negative
|
Kishi, T.,2009(b) |
|
rs1202874 |
GPR50
GPR50-AS1
|
1(1/0/0) |
1
|
X2 goodness of fit test:P-value > 0.05
X2 goodness of fit test:P-value > 0.05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Macintyre, D. J.,2010 |
|
rs2097063 |
COMT
|
1(0/0/1) |
1
|
Allelic association:for MDD, P-value = 0.046, trend P-value......
Allelic association:for MDD, P-value = 0.046, trend P-value = 0.049, OR (95%CI)=1.79(1.01, 3.18)
More...
|
Association was observed in MDD.
Association was observed in MDD.
|
Positive
|
Funke, B.,2005 |
|
rs17452383 |
BTBD10
ARNTL
|
1(0/0/1) |
1
|
X2-tests:allele P-value = 0.938, Model Recessive......
X2-tests:allele P-value = 0.938, Model Recessive, genotype P-value = 0.035, OR(95%CI)=3.00 (1.03-8.77)
More...
|
Significant association was found.
Significant association was found.
|
Positive
|
Soria, V.,2010 |
|
rs688136 |
VIP
|
1(1/0/0) |
1
|
X2-tests:allele P-value > 0.05, genotype P-value......
X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model
More...
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Soria, V.,2010 |
|
rs6079501 |
MACROD2
MACROD2-IT1
SEL1L2
|
1(0/0/1) |
1
|
Omnibus GWAS Test:P-value > 5E-05
Omnibus GWAS Test:P-value > 5E-05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Huang, J.,2010 |
|
rs7305141 |
PAWR
|
1(0/0/1) |
1
|
Hardy-Weinberg equilibrium P value=0.372, genotypic P value......
Hardy-Weinberg equilibrium P value=0.372, genotypic P value=0.0855, allelic P value=0.205 for MDD compared with controls.
More...
|
No association was detected with schizophrenia or MDD in al......
No association was detected with schizophrenia or MDD in allele/genotype-wise analyses.
More...
|
Negative
|
Kishi, T., 2008 (a) |
|
rs2323019 |
FZD3
RNA5SP259
|
1(0/0/1) |
1
|
Allelic association:P-value = 0.91 for MDD
Allelic association:P-value = 0.91 for MDD
|
No association was observed in MDD.
No association was observed in MDD.
|
Negative
|
Hashimoto, R.,2005(b) |
|
rs561077 |
GPR50
GPR50-AS1
|
1(0/0/1) |
1
|
X2 goodness of fit test:P-value > 0.05
X2 goodness of fit test:P-value > 0.05
|
No significant association was observed.
No significant association was observed.
|
Negative
|
Macintyre, D. J.,2010 |
|