BDgene

BD & MDD shared SNPs from cross-disorder studies

Total result: 377

SNP Related Gene(s) No. of Studies (Positive/Trend/Negative) for BD No. of Studies for MDD Overlap with MDD
Statistical Results Description Result Category Reference
rs2391191 DAOA DAOA-AS1 18(3/0/15) 3
Armitage's trend test:P-value = 0.13 Armitage's trend test:P-value = 0.13 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
A vs. G: OR = 0.98; 95% CI = 0.77–1.24; P-value = 0.855 A vs. G: OR = 0.98; 95% CI = 0.77–1.24; P-value = 0.855 No significant association was found between M15 and DD. No significant association was found between M15 and DD. Negative Tan, J., 2014
rs6265 BDNF BDNF-AS 17(7/0/10) 1
Armitage Trend Test:in Bonn sample, for MDD, P-value(odds r...... Armitage Trend Test:in Bonn sample, for MDD, P-value(odds ratio)=0.314(1.10);in Munich sample, for MDD, P-value(odds ratio)=0.881(1.02) More... No association was observed. No association was observed. Negative Schumacher, J.,2005
rs1006737 CACNA1C 15(9/2/4) 3
genotype test P-value = 0.013 when using New controls as co...... genotype test P-value = 0.013 when using New controls as control, genotype test P-value = 3.9E-4 when using WTCCC expanded reference as control, OR(%95 CI) = 1.15 (1.02-1.31) for allele test when using New controls as control, OR(%95 CI) = 1.17 (1.07-1.27) for allele test when using WTCCC expanded reference as control. More... We found that the risk allele conferred increased risk for ...... We found that the risk allele conferred increased risk for recurrent major depression (P= 0.013) with similar effect sizes to those previously observed in BD (allelic odds ratio B1.15). More... Positive Green, E. K., 2010
Meta analysis:P-value = 3.1E-08 Meta analysis:P-value = 3.1E-08 Suggestive association was found. Suggestive association was found. Trend Liu, Y.,2011
rs1935062 DAOA DAOA-AS1 12(6/0/6) 1
Armitage's trend test:P-value = 0.6 Armitage's trend test:P-value = 0.6 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
rs10994336 ANK3 12(7/0/5) 1
Meta analysis:P-value = 5.0E-07 Meta analysis:P-value = 5.0E-07 Suggestive association was found. Suggestive association was found. Trend Liu, Y.,2011
rs3918342 DAOA 11(4/0/7) 2
T vs. C: OR = 0.93; 95% CI = 0.83–1.03; P-value = 0.179 T vs. C: OR = 0.93; 95% CI = 0.83–1.03; P-value = 0.179 Significant association between M23 and DD was not found. Significant association between M23 and DD was not found. Negative Tan, J., 2014
Armitage's trend test:P-value = 0.29 Armitage's trend test:P-value = 0.29 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
rs947267 DAOA DAOA-AS1 9(1/0/8) 2
C vs. A: OR= 1.05, 95% CI = 0.91–1.22, P-value = 0.476; C...... C vs. A: OR= 1.05, 95% CI = 0.91–1.22, P-value = 0.476; CC+CA vs. AA: OR = 1.09, 95%CI = 0.88–1.34, P-value = 0.43; CC vs. CA+AA: OR = 1.05, 95% CI = 0.79–1.40, P-value = 0.748; CC vs. CA: OR = 1.01, 95% CI = 0.75–1.37, P-value = 0.941; CA vs. AA: OR = 1.08, 95% CI = 0.87–1.35, P-value = 0.475; CC vs. AA: OR= 1.10, 95% CI= 0.80–1.51, P-value = 0.544. More... No significant association was found between M18 and DD in ...... No significant association was found between M18 and DD in six models. More... Negative Tan, J., 2014
Armitage's trend test:P-value = 0.99 Armitage's trend test:P-value = 0.99 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
rs2230912 P2RX7 9(2/0/7) 4
Chi-square analysis:1.allele:overall group: X2(1...... Chi-square analysis:1.allele:overall group: X2(1)=1.86, P-value = 0.17; for MDD: X2(1)=0.94, P-value = 0.33; for BPD: X2(1)=1.64, P-value = 0.20 2.genptype:overall group:X2(2, 349)=1.91, P-value = 0.38;for MDD: X2(2, 285)=0.99, P-value = 0.61; for BPD: X2(2242)=1.66, P-value = 0.44 multivariate analysis of variance (MANOVA):1.Genotype GG:Clinical group:F(2, 149)=4.568, P-value(ANOVA)=0.0119 in HADS-anxiety scale;F(2, 149)=8.319, P-value(ANOVA)=0.0004 in HADS-depression scale;Control group:F(2, 134)=0.055, P-value(ANOVA)=0.947 in HADS-anxiety scale;F(2, 134)=0.263, P-value(ANOVA)=0.769 in HADS-depression scale 2.Genotype AG+GG:Clinical group:F(1, 150)=3.949, P-value(ANOVA)=0.00487 in HADS-anxiety scale;F(1.150)=13.091, P-value(ANOVA)=0.0004 in HADS-depression scale;Control group:F(1, 135)=0.021, P-value(ANOVA)=0.884 in HADS-anxiety scale;F(1, 135)=0.024, P-value(ANOVA)=0.876 in HADS-depression scale 3.interaction of clinical status and P2RX7 polymorphism:P-value(ANOVA)=0.025, subsequent ANOVA for anxiety:P-value(ANOVA)=0.252; depression: P-value(ANOVA)=0.002. More... The case-control analysis did not yield significant results...... The case-control analysis did not yield significant results, comparing either the overall patient sample, or the MDD and BPD groups separately to the control group.Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups.A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale. More... Positive Hejjas, K.,2009
P-value>0.05 P-value>0.05 The case-control analyses did not show any significant diff...... The case-control analyses did not show any significant difference in the genotype distributions of the two investigated P2RX7 polymorphisms (i.e.,rs2230912 and rs1653625) between the MDD or the BPD and the control groups. More... Negative Halmai Z, 2013
rs1170191 DGKH 7(1/0/6) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs1935058 DAOA-AS1 DAOA 7(3/0/4) 1
Armitage's trend test:P-value = 0.3 Armitage's trend test:P-value = 0.3 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
rs165599 ARVCF COMT 7(5/0/2) 2
For MD:allele, X2=3.58, P-value = 0.05, genotype...... For MD:allele, X2=3.58, P-value = 0.05, genotype, X2=4.35, P-value = 0.1;eraly onset:allele, X2=2.56, P-value = 0.11, genotype, X2=3.25, P-value = 0.2 More... No significant association was observed. No significant association was observed. Negative Massat, I.,2011
Allelic association:for MDD, P-value = 0.169, trend P-value...... Allelic association:for MDD, P-value = 0.169, trend P-value = 0.184, OR (95%CI)=1.46(0.85, 2.51) More... No association was observed in MDD. No association was observed in MDD. Negative Funke, B.,2005
rs1012053 DGKH 6(1/0/5) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs1801260 CLOCK TMEM165 6(3/0/3) 3
For MDD:Allele T, unadjusted analyses, OR=1.12, 95%CI=0.790...... For MDD:Allele T, unadjusted analyses, OR=1.12, 95%CI=0.790-1.59, P-value = 0.519;adjusted analyses, OR=1.13, 95%CI=0.785-1.59, P-value = 0.542. Recessive:genotype TT and TC, unadjusted analyses, OR=1.07, 95%CI=0.359-2.57, P-value = 0.893;adjusted analyses, OR=1.08, 95%CI=0.364-2.62, P-value = 0.87 .Dominant:genotype TT, unadjusted analyses, OR=0.85, 95%CI=0.562-1.26, P-value = 0.428;adjusted analyses, OR=0.847, 95%CI=0.560-1.26, P-value = 0.422. Co-dominant:genotype TT, unadjusted analyses, OR=0.898, 95%CI=0.401-1.78, P-value = 0.761;adjusted analyses, OR=0.898, 95%CI=0.403-1.79, P-value = 0.773;Co-dominant:genotype TC, unadjusted analyses, OR=1.3, 95%CI=0.550-2.86, P-value = 0.525;adjusted analyses, OR=1.32, 95%CI=0.557-2.91, P-value = 0.504 More... No significant association was observed. No significant association was observed. Negative Kishi, T.,2011(c)
chi-square test: 1. total samples:P-value = 0.833(Genotype)...... chi-square test: 1. total samples:P-value = 0.833(Genotype), P-value = 0.972(Allele) in MDD 2. male samples: P-value = 0.451(Genotype), P-value = 0.746(Allele) in MDD 3. female samples: P-value = 0.648(Genotype), P-value = 0.872(Allele) in MDD More... We did not find an association between these tag SNPs and J...... We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses. More... Negative Kishi, T.,2009(a)
rs9315885 DGKH MAPK6PS3 6(0/0/6) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs4680 COMT 6(3/0/3) 2
For MD:allele, X2=0.82, P-value = 0.36, genotype...... For MD:allele, X2=0.82, P-value = 0.36, genotype, X2=6.6, P-value = 0.03;eraly onset:allele, X2=0.83, P-value = 0.36, genotype, X2=5.62, P-value = 0.05 More... Significant association was found in genotype for MD. Significant association was found in genotype for MD. Positive Massat, I.,2011
Allelic association:for MDD, P-value = 0.101, trend P-value...... Allelic association:for MDD, P-value = 0.101, trend P-value = 0.093, OR (95%CI)=1.56(0.91, 2.68) More... No association was observed in MDD. No association was observed in MDD. Negative Funke, B.,2005
rs3738401 DISC1 TSNAX 5(0/0/5) 1
genotypic/allelic test P-value: 0.77/0.59 genotypic/allelic test P-value: 0.77/0.59 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs1487275 TPH2 5(0/0/5) 1
genotypic P-value = 0.57, allelic P-value = 0.53 genotypic P-value = 0.57, allelic P-value = 0.53 Negative Van Den Bogaert, A., 2006 (a)
rs737865 COMT TXNRD2 5(2/0/3) 2
For MD:allele, X2=0.85, P-value = 0.35, genotype...... For MD:allele, X2=0.85, P-value = 0.35, genotype, X2=1.25, P-value = 0.52;eraly onset:allele, X2=3.95, P-value = 0.04, genotype, X2=4.3, P-value = 0.12 More... No significant association was observed. No significant association was observed. Negative Massat, I.,2011
Allelic association:for MDD, P-value = 0.688, trend P-value...... Allelic association:for MDD, P-value = 0.688, trend P-value = 0.689, OR (95%CI)=1.12(0.64, 1.95) More... No association was observed in MDD. No association was observed in MDD. Negative Funke, B.,2005
rs2251219 PBRM1 SMIM4 RNU6-856P 5(5/0/0) 2
P-value=0.008059, OR=1.062 for MDD, P-value=0.00000001913, ...... P-value=0.008059, OR=1.062 for MDD, P-value=0.00000001913, OR=1.1 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.2. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs2251219 was significantly associated with major mood diso...... rs2251219 was significantly associated with major mood disorder. The findings were more robust in bipolar disorder than in MDD.The result is replicable in replication samples. We did not find a significant association signal at any of these loci after genome-wide correction for multiple testing. Our genetic association results provide support for the previous epidemiologic evidence of genetic overlap between bipolar disorder and MDD. More... Positive McMahon, F. J., 2010
rs9371601 SYNE1 5(4/1/0) 1
Association analysis:genotype trend P-value = 0.063, allele...... Association analysis:genotype trend P-value = 0.063, allele OR (95% CI)=1.111 (0.99--1.24) with independent control;genotype trend P-value = 0.032, allele OR (95% CI)=1.118 (1.01--1.24) with all controls (WTCCC and independent) More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Green EK, 2013
rs11178997 TPH2 5(1/0/4) 1
genotypic P-value = 0.001, allelic P-value = 0.001 genotypic P-value = 0.001, allelic P-value = 0.001 In the sample of patients with UP disorder and controls, si...... In the sample of patients with UP disorder and controls, significant association was observed for the A allele of rs11178997. More... Positive Van Den Bogaert, A., 2006 (a)
rs766288 TSNAX DISC1 4(1/0/3) 2
chi square test:genotype P-value = 0.0742, allele P-value =...... chi square test:genotype P-value = 0.0742, allele P-value = 0.0727 More... No significant association was observed. No significant association was observed. Negative Okuda, A.,2010
genotypic/allelic test P-value: 0.27/0.15 genotypic/allelic test P-value: 0.27/0.15 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs1000731 DISC1 TSNAX 4(0/0/4) 1
genotypic/allelic test P-value: 0.84/0.57 genotypic/allelic test P-value: 0.84/0.57 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs4792887 CRHR1 MAPT-AS1 4(0/0/4) 1
allelic P-value=0.201, genotypic P-value=0.266, OR=1.631, 9...... allelic P-value=0.201, genotypic P-value=0.266, OR=1.631, 95% CI=0.665-1.080 for affective disorder; allelic P-value=0.431, genotypic P-value=0.443, OR=0.853, 95% CI=0.598-1.218 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs110402 CRHR1 MAPT-AS1 4(0/0/4) 1
allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 9...... allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 95% CI=0.755-1.013 for affective disorder; allelic P-value=0.144, genotypic P-value=0.238, OR=0.852, 95% CI=0.689-1.054 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs1360780 FKBP5 4(0/0/4) 1
P-value=0.011 P-value=0.011 Our main finding is an association of FKBP5 polymorphisms (...... Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. More... Positive Szczepankiewicz A., 2014
rs6313 HTR2A 4(0/0/4) 2
Overall: T vs. C (Allele frequency): OR=1.006, 95%CI=0.914-...... Overall: T vs. C (Allele frequency): OR=1.006, 95%CI=0.914-1.107, P-value=0.908; TT + TC vs. CC (Dominant): OR=0.999, 95%CI=0.845-1.181, P-value=0.994; TT vs. TC + CC (Recessive): OR=1.033, 95%CI=0.919-1.161, P-value=0.592; TT vs. TC (Codominant1): OR=1.022, 95%CI=0.903-1.158, P-value=0.73; TC vs. CC (Codominant2): OR=1.012, 95%CI=0.891-1.148, P-value=0.856; TT vs. CC (Homozygote): OR=0.993, 95%CI=0.807-1.222, P-value=0.949. Caucasian: T vs. C (Allele frequency): OR=1.055, 95%CI=0.894-1.246, P-value=0.528; TT + TC vs. CC (Dominant): OR=1.085, 95%CI=0.806-1.461, P-value=0.689; TT vs. TC + CC (Recessive): OR=1.068, 95%CI=0.852-1.339, P-value=0.568; TT vs. TC (Codominant1): OR=1.028, 95%CI=0.809-1.306, P-value=0.824; TC vs. CC (Codominant2): OR=1.085, 95%CI=0.878-1.342, P-value=0.449; TT vs. CC (Homozygote): OR=1.092, 95%CI=0.781-1.527, P-value=0.607. Asian: T vs. C (Allele frequency): OR=0.980, 95%CI=0.868-1.106, P-value=0.743; TT + TC vs. CC (Dominant): OR=0.950, 95%CI=0.772-1.169, P-value=0.629; TT vs. TC + CC (Recessive): OR=1.020, 95%CI=0.890-1.169, P-value=0.778; TT vs. TC (Codominant1): OR=1.020, 95%CI=0.882-1.180, P-value=0.788; TC vs. CC (Codominant2): OR=0.973, 95%CI=0.831-1.139, P-value=0.737; TT vs. CC (Homozygote): OR=0.936, 95%CI=0.713-1.229, P-value=0.635. Chinese: T vs. C (Allele frequency): OR=1.008, 95%CI=0.864-1.177, P-value=0.917; TT + TC vs. CC (Dominant): OR=1.034, 95%CI=0.850-1.259, P-value=0.736; TT vs. TC + CC (Recessive): OR=1.042, 95%CI=0.877-1.238, P-value=0.637; TT vs. TC (Codominant1): OR=1.021, 95%CI=0.851-1.225, P-value=0.823; TC vs. CC (Codominant2): OR=1.026, 95%CI=0.833-1.264, P-value=0.81; TT vs. CC (Homozygote): OR=0.977, 95%CI=0.664-1.436, P-value=0.905 More... The results of our study indicate that theT102C polymorphis...... The results of our study indicate that theT102C polymorphism is not associates with increased susceptibility to MDD. More... Negative Tan J., 2014
chi-square test: 1.total samples:P-value = 0.430(Genotype),...... chi-square test: 1.total samples:P-value = 0.430(Genotype), P-value = 0.254(Allele) in Mood disorders;P-value = 0.883(Genotype), P-value = 0.656(Allele) in MDD 2. male samples: P-value = 0.424(Genotype), P-value = 0.240(Allele) in Mood disorders;P-value = 0.616(Genotype), P-value = 0.361(Allele) in MDD 3. female samples: P-value = 0.310(Genotype), P-value = 0.731(Allele) in Mood disorders;P-value = 0.763(Genotype), P-value = 0.732(Allele) in MDD More... we did not detect any significant association of HTR2A with...... we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. More... Negative Kishi, T.,2009(b)
rs6675281 DISC1 TSNAX 4(0/0/4) 1
genotypic/allelic test P-value: 0.47/0.23 genotypic/allelic test P-value: 0.47/0.23 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs3916966 DAOA-AS1 DAOA 4(1/0/3) 1
Armitage's trend test:P-value = 0.54 Armitage's trend test:P-value = 0.54 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
rs6196 NR3C1 4(1/0/3) 1
X2 test:allele, P-value > 0.05;the Fisher exact ...... X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A.,2011
rs10052957 NR3C1 4(1/0/3) 1
X2 test:allele, P-value > 0.05;the Fisher exact ...... X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A.,2011
rs6198 NR3C1 4(0/0/4) 1
X2 test:allele, P-value > 0.05;the Fisher exact ...... X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value = 0.018, df=2, X2=7.964, OR=0.950, 95% CI: 0.693-1.303. More... Significant association was found. Significant association was found. Positive Szczepankiewicz, A.,2011
rs1843809 TPH2 4(1/0/3) 1
genotypic P-value = 0.81, allelic P-value = 0.78 genotypic P-value = 0.81, allelic P-value = 0.78 Negative Van Den Bogaert, A., 2006 (a)
rs258813 NR3C1 3(0/0/3) 1
X2 test:allele, P-value > 0.05;the Fisher exact ...... X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A.,2011
rs1982350 ARNTL 3(2/0/1) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs1630250 TSNAX DISC1 3(0/0/3) 1
chi square test:genotype P-value = 0.356, allele P-value = ...... chi square test:genotype P-value = 0.356, allele P-value = 0.165 More... No significant association was observed. No significant association was observed. Negative Okuda, A.,2010
rs3789327 ARNTL 3(2/0/1) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs242950 CRHR1 MAPT-AS1 3(0/0/3) 1
allelic P-value=0.407, genotypic P-value=0.671, OR=0.901, 9...... allelic P-value=0.407, genotypic P-value=0.671, OR=0.901, 95% CI=0.716-1.134 for affective disorder; allelic P-value=0.867, genotypic P-value=0.958, OR=0.954, 95% CI=0.686-1.327 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs28536160 AVPR1B 3(1/0/2) 1
allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 9...... allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 95% CI=0.607-1.067 for affective disorder; allelic P-value=1, genotypic P-value=0.387, OR=1.001, 95% CI=0.662-1.514 for MDD More... In the single marker association analysis of AVPR1b gene we...... In the single marker association analysis of AVPR1b gene we observed an association of rs28536160 with mood disorders (P=0.036); this was not observed in the bipolar disorder and MDD patients separately. More... Negative Szczepankiewicz, A., 2013
rs41423247 NR3C1 3(0/0/3) 1
X2 test:allele, P-value > 0.05;the Fisher exact ...... X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A.,2011
rs2535629 ITIH3 3(3/0/0) 2
Association analysis:P-value = 0.00000000000254,OR(95%CI) =...... Association analysis:P-value = 0.00000000000254,OR(95%CI) = 1.1(1.07–1.12) when five disorders were combined More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
P-value=0.0009575, OR=0.9239 for MDD, P-value=0.00000000588...... P-value=0.0009575, OR=0.9239 for MDD, P-value=0.000000005883, OR=0.8998 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.1. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs6191 NR3C1 3(0/0/3) 1
X2 test:allele, P-value = 0.015 for alleles, OR=...... X2 test:allele, P-value = 0.015 for alleles, OR=1.338, 95% CI: 1.059-1.689;the Fisher exact test:genotype, P-value = 0.049 More... Significant association was found. Significant association was found. Positive Szczepankiewicz, A.,2011
rs2071427 NR1D1 THRA 3(1/0/2) 2
Hardy-Weinberg equilibrium P value=0.600, genotypic P value...... Hardy-Weinberg equilibrium P value=0.600, genotypic P value=0.911, allelic P value=0.706 for MDD. More... No significant association was found with major depressive ...... No significant association was found with major depressive disorder. More... Negative Kishi, T., 2008 (b)
X2-tests:allele P-value = 0.235, Model Recessive...... X2-tests:allele P-value = 0.235, Model Recessive, genotype P-value = 0.039, OR(95%CI)=1.80 (1.03-3.16) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs2492367 DISC1 TSNAX 3(1/0/2) 1
genotypic/allelic test P-value: 0.31/0.97 genotypic/allelic test P-value: 0.31/0.97 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs6850524 CLOCK 3(2/0/1) 1
X2-tests:allele P-value = 0.056, Model Log-addit...... X2-tests:allele P-value = 0.056, Model Log-additive, genotype P-value = 0.015, OR(95%CI)=1.30 (1.05-1.61) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs3800373 FKBP5 3(1/0/2) 1
P-value=0.083 P-value=0.083 association analysis for single polymorphisms within FKBP5 ...... association analysis for single polymorphisms within FKBP5 gene More... Negative Szczepankiewicz A., 2014
rs6903874 TAAR6 3(1/0/2) 1
The significant association of rs6903874 with BID was not o...... The significant association of rs6903874 with BID was not observed in the overall groups of patients with MDD nor in the patients with psychotic MDD vs. controls. More... Negative Pae, C. U., 2008
rs2278749 ARNTL 3(1/0/2) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs10748185 TPH2 3(2/0/1) 1
genotypic P-value = 0.48, allelic P-value = 0.48 genotypic P-value = 0.48, allelic P-value = 0.48 Negative Van Den Bogaert, A., 2006 (a)
rs3736544 CLOCK TMEM165 3(1/0/2) 2
For MDD:Allele G, unadjusted analyses, OR=0.783, 95%CI=0.58...... For MDD:Allele G, unadjusted analyses, OR=0.783, 95%CI=0.585-1.05, P-value = 0.0989;adjusted analyses, OR=0.787, 95%CI=0.588-1.05, P-value = 0.106. Recessive:genotype GG and GT, unadjusted analyses, OR=2.19, 95%CI=1.10-4.10, P-value = 0.0187(0.224);adjusted analyses, OR=2.23, 95%CI=1.11-4.20, P-value = 0.0174(0.209) .Dominant:genotype GG, unadjusted analyses, OR=1.18, 95%CI=0.818-1.69, P-value = 0.372;adjusted analyses, OR=1.12, 95%CI=0.774-1.60, P-value = 0.551. Co-dominant:genotype GG, unadjusted analyses, OR=1.75, 95%CI=0.986-3.04, P-value = 0.0506;adjusted analyses, OR=1.67, 95%CI=0.939-2.92, P-value = 0.074;Co-dominant:genotype GT, unadjusted analyses, OR=0.161, 95%CI=0.873-2.96, P-value = 0.123;adjusted analyses, OR=1.74, 95%CI=0.940-3.21, P-value = 0.0751 More... Significant association was observed in recessive model , b...... Significant association was observed in recessive model , but this significance did not survive Bonferroni correction. More... Positive Kishi, T.,2011(c)
chi-square test: 1. total samples: P-value = 0.914(Genotype...... chi-square test: 1. total samples: P-value = 0.914(Genotype), P-value = 0.334(Allele) in MDD 2. male samples: P-value = 0.160(Genotype), P-value = 0.229(Allele) in MDD 3. female samples: P-value = 0.233(Genotype), P-value = 0.316(Allele) in MDD More... We did not find an association between these tag SNPs and J...... We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses. More... Negative Kishi, T.,2009(a)
rs28373064 AVPR1B 3(0/0/3) 1
allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 9...... allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 95% CI=0.766-1.119 for affective disorder; allelic P-value=0.514, genotypic P-value=0.399, OR=1.099, 95% CI=0.830-1.454 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs821597 DISC1 TSNAX 3(0/0/3) 1
genotypic/allelic test P-value: 0.40/0.28 genotypic/allelic test P-value: 0.40/0.28 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs33388 NR3C1 3(0/0/3) 1
X2 test:allele, P-value = 0.018, OR=0.759, 95% C...... X2 test:allele, P-value = 0.018, OR=0.759, 95% CI=0.605-0.953;the Fisher exact test:genotype, P-value > 0.05 More... Significant association was found. Significant association was found. Positive Szczepankiewicz, A.,2011
rs646558 NCAM1 3(1/0/2) 1
Fisher's exact test genotypic P-value = 0.51 , allelic P-va...... Fisher's exact test genotypic P-value = 0.51 , allelic P-value = 0.64 More... For unipolar disorder, none of these polymorphisms displaye...... For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease. More... Negative Arai, M., 2004
rs1997644 CSNK1E 3(2/0/1) 2
Chi square test:MAF = 0.37,P-value = 0.49,OR = 0.95 Chi square test:MAF = 0.37,P-value = 0.49,OR = 0.95 No significant association was observed. No significant association was observed. Negative Matsunaga, S.,2012
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs173365 CRHR1 MAPT-AS1 3(0/0/3) 1
allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 9...... allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 95% CI=0.877-1.180 for affective disorder; allelic P-value=0.476, genotypic P-value=0.469, OR=1.088, 95% CI=0.876-1.350 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs1800532 TPH1 3(1/0/2) 1
Meta analysis:On the basis of the random effect model, P-va...... Meta analysis:On the basis of the random effect model, P-value > 0.05 in any genetic models either in Caucasians or in Asians. More... On the basis of the random effect model, no significant ass...... On the basis of the random effect model, no significant association between TPH1 A218C polymorphism and MDD risk was found in any genetic models either in Caucasians or in Asians. More... Negative Chen, D.,2011
rs9296158 FKBP5 3(1/0/2) 1
P-value=0.03 P-value=0.03 Our main finding is an association of FKBP5 polymorphisms (...... Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. More... Positive Szczepankiewicz A., 2014
rs9315897 DGKH 3(0/0/3) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs28632197 AVPR1B 3(0/0/3) 1
allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 9...... allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 95% CI=0.763-1.244 for affective disorder; allelic P-value=0.397, genotypic P-value=0.353, OR=0.853, 95% CI=0.597-1.219 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs4076452 CRHR1 3(0/0/3) 1
allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 9...... allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 95% CI=0.940-1.386 for affective disorder; allelic P-value=0.177, genotypic P-value=0.02, OR=1.225, 95% CI=0.917-1.635 for MDD More... We found that rs4076452 was significantly associated with a...... We found that rs4076452 was significantly associated with an increased risk for MDD in our group. More... Positive Szczepankiewicz, A., 2013
rs878886 CRHR1 MAPT-AS1 3(0/0/3) 1
allelic P-value=0.113, genotypic P-value=0.258, OR=1.176, 9...... allelic P-value=0.113, genotypic P-value=0.258, OR=1.176, 95% CI=0.967-1.430 for affective disorder; allelic P-value=0.768, genotypic P-value=0.941, OR=1.047, 95% CI=0.785-1.394 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs35369693 AVPR1B 3(0/0/3) 1
allelic P-value=0.729, genotypic P-value=0.907, OR=0.934, 9...... allelic P-value=0.729, genotypic P-value=0.907, OR=0.934, 95% CI=0.682-1.279 for affective disorder; allelic P-value=0.71, genotypic P-value=0.797, OR=0.925, 95% CI=0.573-1.492 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs1049353 CNR1 2(0/0/2) 1
Pearson's X2 test: X2= 10.321; df = 2...... Pearson's X2 test: X2= 10.321; df = 2, P-value = 0.005 for genotypes; X2= 12.469;df = 1, P-value = 0.0004 for alleles More... Significant association was found. Significant association was found. Positive Monteleone, P.,2010
rs9470080 FKBP5 2(0/0/2) 1
P-value=0.007 P-value=0.007 Our main finding is an association of FKBP5 polymorphisms (...... Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. More... Positive Szczepankiewicz A., 2014
rs2156921 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value = 0.031, OR=1.29 Allelic association:for MDD, P-value = 0.031, OR=1.29 Significant associations were found in MDD. Significant associations were found in MDD. Positive Hashimoto, R.,2005(a)
rs988748 BDNF 2(0/0/2) 1
Armitage Trend Test:in Bonn sample, for MDD, P-value(odds r...... Armitage Trend Test:in Bonn sample, for MDD, P-value(odds ratio)=0.651(1.04);in Munich sample, for MDD, P-value(odds ratio)=0.470(1.10) More... No association was observed. No association was observed. Negative Schumacher, J.,2005
rs2267013 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value = 0.044, OR=1.27 Allelic association:for MDD, P-value = 0.044, OR=1.27 Significant associations were found in MDD. Significant associations were found in MDD. Positive Hashimoto, R.,2005(a)
rs3755806 PBRM1 2(1/1/0) 1
P-value=0.006818, OR=1.063 for MDD, P-value=0.00000003091, ...... P-value=0.006818, OR=1.063 for MDD, P-value=0.00000003091, OR=1.098 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.8. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs131702 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value > 0.05 Allelic association:for MDD, P-value > 0.05 No significant associations were found in MDD. No significant associations were found in MDD. Negative Hashimoto, R.,2005(a)
rs140504 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value > 0.05 Allelic association:for MDD, P-value > 0.05 No significant associations were found in MDD. No significant associations were found in MDD. Negative Hashimoto, R.,2005(a)
rs1611115 DBH 2(1/0/1) 1
DBH genotype and affective disorders:total(X2 = ...... DBH genotype and affective disorders:total(X2 = 0.55, P-value = 0.758), Unipolar(X2 = 2.05, P-value = 0.359), Bipolar(X2 = 0.90, P-value = 0.638) More... No differences in DBH C-1021T genotype distribution were ob...... No differences in DBH C-1021T genotype distribution were observed More... Negative Hess, C.,2009
rs778336 DAOA-AS1 DAOA 2(0/0/2) 1
For MDD, allele, P-value = 0.0406;For Mood, allele, P-value...... For MDD, allele, P-value = 0.0406;For Mood, allele, P-value = 0.031, OR=0.8072, P-value(perm)=0.769 More... Significant association was found. Significant association was found. Positive Soronen, P.,2011
rs969486 ARNTL 2(1/0/1) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs3794808 SLC6A4 2(0/0/2) 1
For MDD, allele, P-value = 0.0046;For Mood, allele, P-value...... For MDD, allele, P-value = 0.0046;For Mood, allele, P-value = 0.0115, OR=0.8167, P-value(perm)=0.432 More... Significant association was found. Significant association was found. Positive Soronen, P.,2011
rs956572 BCL2 2(0/0/2) 1
chi-square tests:genotype, MDD(P-value = 0.31, X2 chi-square tests:genotype, MDD(P-value = 0.31, X2=2.32);allele, MDD[P-value = 0.89;OR = 0.95, 95% CI:(0.52-1.75), X2=0.02] More... No significant association was observed. No significant association was observed. Negative Uemura, T.,2011
rs324420 FAAH 2(0/0/2) 1
Pearson's X2 test:Genotype frequencies with MD p...... Pearson's X2 test:Genotype frequencies with MD patients ( X2=3.748;df = 1, P-value = 0.05) More... No significant association was observed. No significant association was observed. Negative Monteleone, P.,2010
rs2267020 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value > 0.05 Allelic association:for MDD, P-value > 0.05 No significant associations were found in MDD. No significant associations were found in MDD. Negative Hashimoto, R.,2005(a)
rs1024582 CACNA1C CACNA1C-IT3 2(2/0/0) 1
Association analysis:P-value = 0.0000000187,OR(95%CI) = 1.0...... Association analysis:P-value = 0.0000000187,OR(95%CI) = 1.07(1.05-1.10) when BD and SZ were combined More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
rs12504300 CLOCK 2(2/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs228642 PER3 2(1/0/1) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs12936511 CRHR1 MAPT-AS1 2(0/0/2) 1
allelic P-value=0.362, genotypic P-value=0.269, OR=0.828, 9...... allelic P-value=0.362, genotypic P-value=0.269, OR=0.828, 95% CI=0.603-1.180 for affective disorder; allelic P-value=0.904, genotypic P-value=0.962, OR=0.947, 95% CI=0.587-1.526 for MDD More... No significant association was observed. No significant association was observed. Negative Szczepankiewicz, A., 2013
rs939347 NR1D1 2(0/0/2) 1
Hardy-Weinberg equilibrium P value=0.178, genotypic P value...... Hardy-Weinberg equilibrium P value=0.178, genotypic P value=0.907, allelic P value=0.831 for MDD. More... No significant association was found with major depressive ...... No significant association was found with major depressive disorder. More... Negative Kishi, T., 2008 (b)
rs13440581 GPR50 GPR50-AS1 2(1/0/1) 2
X2 goodness of fit test:P-value > 0.05 X2 goodness of fit test:P-value > 0.05 No significant association was observed. No significant association was observed. Negative Macintyre, D. J.,2010
Single marker association:for MDD, allele P-value = 0.04(al...... Single marker association:for MDD, allele P-value = 0.04(all), P-value = 0.99(male), P-value = 0.0096(female) More... Association was observed in MDD and MDD(female). Association was observed in MDD and MDD(female). Positive Thomson, P. A.,2005(b)
rs723672 CACNA1C CACNA1C-IT2 2(0/0/2) 1
genotypic P-value=0.56, X2=1.16, allelic P-value...... genotypic P-value=0.56, X2=1.16, allelic P-value=0.56, OR(95%CI)=1.05(0.88-1.26) More... Neither allele nor genotype frequencies of the three SNPs w...... Neither allele nor genotype frequencies of the three SNPs were significantly different between MDD patients and control subjects. More... Negative Zhang X, 2013
rs12966547 CCDC68 2(2/0/0) 1
Association analysis:P-value = 0.00000000026 when BPD,MDD a...... Association analysis:P-value = 0.00000000026 when BPD,MDD and SZ were combined. More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
rs878567 HTR1A 2(1/0/1) 1
Meta analysis:P (allele model) = 0.0007 and P (dominant mod...... Meta analysis:P (allele model) = 0.0007 and P (dominant model) = 0.01 More... Significant association was found. Significant association was found. Positive Kishi, T.,2012(a)
rs41279104 NOS1 2(0/0/2) 1
genotype test P-value = 0.787, allele test P-value = 0.531. genotype test P-value = 0.787, allele test P-value = 0.531. no association was observed. no association was observed. Negative Okumura, T., 2010
rs17025005 NPAS2 2(1/0/1) 1
X2-tests:allele P-value = 0.092, Model Dominant,...... X2-tests:allele P-value = 0.092, Model Dominant, genotype P-value = 0.039, OR(95%CI)=0.72 (0.53-0.98) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs755658 FKBP5 2(0/0/2) 1
P-value=0.46 P-value=0.46 association analysis for single polymorphisms within FKBP5 ...... association analysis for single polymorphisms within FKBP5 gene More... Negative Szczepankiewicz A., 2014
rs1928040 HTR2A 2(0/0/2) 1
chi-square test: 1.total samples:P-value = 0.894(Genotype),...... chi-square test: 1.total samples:P-value = 0.894(Genotype), P-value = 0.888(Allele) in Mood disorders;P-value = 0.370(Genotype), P-value = 0.499(Allele) in MDD 2. male samples: P-value = 0.929(Genotype), P-value = 0.977(Allele) in Mood disorders;P-value = 0.623(Genotype), P-value = 0.524(Allele) in MDD 3. female samples: P-value = 0.930(Genotype), P-value = 0.837(Allele) in Mood disorders;P-value = 0.551(Genotype), P-value = 0.771(Allele) in MDD More... we did not detect any significant association of HTR2A with...... we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. More... Negative Kishi, T.,2009(b)
rs6465084 GRM3 2(0/0/2) 1
For MDD:Genotypic association:P-value = 0.0344, allelic ass...... For MDD:Genotypic association:P-value = 0.0344, allelic association:P-value = 0.00928 More... We found an association between rs6465084 in GRM3 and MDD i...... We found an association between rs6465084 in GRM3 and MDD in the allele-wise analysis after Bonferroni's correction. More... Positive Tsunoka, T.,2009
rs6438552 GSK3B 2(0/0/2) 1
association analyses with diagnosis:codominant P-value = 0....... association analyses with diagnosis:codominant P-value = 0.228, dominant P-value = 0.277, recessive P-value = 0.109, additive P-value = 0.102 More... No significant association was observed. No significant association was observed. Negative Saus, E.,2010
rs4279178 GABRB1 ADM 2(1/1/0) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs3761418 BCR BCRP8 2(1/0/1) 1
Allelic association:for MDD, P-value = 0.012, OR=1.32 Allelic association:for MDD, P-value = 0.012, OR=1.32 Significant associations were found in MDD. Significant associations were found in MDD. Positive Hashimoto, R.,2005(a)
rs2279287 ARNTL 2(1/0/1) 1
X2-tests:allele P-value = 0.178, Model Dominant,...... X2-tests:allele P-value = 0.178, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.71 (0.53-0.95) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs2213172 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value = 0.031, OR=1.28 Allelic association:for MDD, P-value = 0.031, OR=1.28 Significant associations were found in MDD. Significant associations were found in MDD. Positive Hashimoto, R.,2005(a)
rs1610037 ADCYAP1 2(1/0/1) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs208294 P2RX7 2(0/0/2) 1
For MDD, allele, P-value = 0.007;For Mood, allele, P-value ...... For MDD, allele, P-value = 0.007;For Mood, allele, P-value = 0.0033, OR=1.26, P-value(perm)=0.158 More... Significant association was found. Significant association was found. Positive Soronen, P.,2011
rs2072621 GPR50 GPR50-AS1 2(0/0/2) 2
X2 goodness of fit test:P-value > 0.05 X2 goodness of fit test:P-value > 0.05 No significant association was observed. No significant association was observed. Negative Macintyre, D. J.,2010
Single marker association:for MDD, allele P-value = 0.58(al...... Single marker association:for MDD, allele P-value = 0.58(all), P-value = 0.19(male), P-value = 0.97(female) More... No association was observed. No association was observed. Negative Thomson, P. A.,2005(b)
rs4713916 FKBP5 2(0/0/2) 1
P-value=0.038 P-value=0.038 Our main finding is an association of FKBP5 polymorphisms (...... Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. More... Positive Szczepankiewicz A., 2014
rs7297582 CACNA1C 2(0/1/1) 1
Meta analysis:P-value = 3.4E-08 Meta analysis:P-value = 3.4E-08 Suggestive association was found. Suggestive association was found. Trend Liu, Y.,2011
rs2267015 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value = 0.023, OR=1.3 Allelic association:for MDD, P-value = 0.023, OR=1.3 Significant associations were found in MDD. Significant associations were found in MDD. Positive Hashimoto, R.,2005(a)
rs6295 HTR1A 2(2/0/0) 1
Meta analysis:MDD: P (allele model) = 0.006, P (recessive m...... Meta analysis:MDD: P (allele model) = 0.006, P (recessive model) = 0.01 More... Significant association was found. Significant association was found. Positive Kishi, T.,2012(a)
rs1653625 P2RX7 2(1/0/1) 1
P-value>0.05 P-value>0.05 The case-control analyses did not show any significant diff...... The case-control analyses did not show any significant difference in the genotype distributions of the two investigated P2RX7 polymorphisms (i.e.,rs2230912 and rs1653625) between the MDD or the BPD and the control groups. More... Negative Halmai Z, 2013
rs2129575 TPH2 2(0/0/2) 1
genotypic P-value = 0.43, allelic P-value = 0.43 genotypic P-value = 0.43, allelic P-value = 0.43 Negative Van Den Bogaert, A., 2006 (a)
rs13025524 NPAS2 2(1/0/1) 1
X2-tests:allele P-value = 0.017, Model Recessive...... X2-tests:allele P-value = 0.017, Model Recessive, genotype P-value = 0.004, OR(95%CI)=0.52 (0.33-0.83) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs716934 DGKH 2(0/0/2) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs131690 BCR 2(1/0/1) 1
Allelic association:for MDD, P-value > 0.05 Allelic association:for MDD, P-value > 0.05 No significant associations were found in MDD. No significant associations were found in MDD. Negative Hashimoto, R.,2005(a)
rs2075507 COMT TXNRD2 2(0/0/2) 1
For MD:allele, X2=0.05, P-value = 0.81, genotype...... For MD:allele, X2=0.05, P-value = 0.81, genotype, X2=2.43, P-value = 0.29;eraly onset:allele, X2=0.99, P-value = 0.75, genotype, X2=0.63, P-value = 0.72 More... No significant association was observed. No significant association was observed. Negative Massat, I.,2011
rs686050 NCAM1 2(1/0/1) 1
Fisher's exact test genotypic P-value = 0.45 , allelic P-va...... Fisher's exact test genotypic P-value = 0.45 , allelic P-value = 0.48 More... For unipolar disorder, none of these polymorphisms displaye...... For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease. More... Negative Arai, M., 2004
rs4131348 TBC1D15 TPH2 2(1/0/1) 1
genotypic P-value = 0.54, allelic P-value = 0.54 genotypic P-value = 0.54, allelic P-value = 0.54 Negative Van Den Bogaert, A., 2006 (a)
rs591874 P2RX7 2(0/0/2) 1
For MDD, allele, P-value = 0.0053;For Mood, allele, P-value...... For MDD, allele, P-value = 0.0053;For Mood, allele, P-value = 0.0103, OR=0.8096, P-value(perm)=0.402 More... Significant association was found. Significant association was found. Positive Soronen, P.,2011
rs3749474 CLOCK TMEM165 2(0/0/2) 2
For MDD:Allele T, unadjusted analyses, OR=0.938, 95%CI=0.72...... For MDD:Allele T, unadjusted analyses, OR=0.938, 95%CI=0.724-1.22, P-value = 0.63;adjusted analyses, OR=0.937, 95%CI=0.723-1.22, P-value = 0.626. Recessive:genotype TT and TC, unadjusted analyses, OR=1.35, 95%CI=0.828-2.14, P-value = 0.21;adjusted analyses, OR=1.33, 95%CI=0.816-2.11, P-value = 0.233 .Dominant:genotype TT, unadjusted analyses, OR=0.958, 95%CI=0.667-1.38, P-value = 0.817;adjusted analyses, OR=0.922, 95%CI=0.641-1.34, P-value = 0.665. Co-dominant:genotype TT, unadjusted analyses, OR=1.06, 95%CI=0.609-1.77, P-value = 0.821;adjusted analyses, OR=1.01, 95%CI=0.607-1.68, P-value = 0.972;Co-dominant:genotype TC, unadjusted analyses, OR=1.4, 95%CI=0.851-2.32, P-value = 0.185;adjusted analyses, OR=1.45, 95%CI=0.874-2.40, P-value = 0.152 More... No significant association was observed. No significant association was observed. Negative Kishi, T.,2011(c)
chi-square test: 1.total samples:P-value = 0.793(Genotype),...... chi-square test: 1.total samples:P-value = 0.793(Genotype), P-value = 0.547(Allele) in MDD 2. male samples: P-value = 0.540(Genotype), P-value = 0.409(Allele) in MDD 3. female samples: P-value = 0.822(Genotype), P-value = 0.925(Allele) in MDD More... We did not find an association between these tag SNPs and J...... We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses. More... Negative Kishi, T.,2009(a)
rs11123857 NPAS2 2(1/0/1) 1
X2-tests:allele P-value = 2E-04, Model Log-addit...... X2-tests:allele P-value = 2E-04, Model Log-additive, genotype P-value = 7.4E-04, OR(95%CI)=1.51 (1.19-1.92) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs1170098 DGKH 2(0/0/2) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs11048994 ARNTL2 1(1/0/0) 1
X2-tests:allele P-value = 0.156, Model Codominan...... X2-tests:allele P-value = 0.156, Model Codominant, genotype P-value = 0.014, OR(95%CI)=0.65 (0.47-0.90) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs11921360 GSK3B 1(0/0/1) 1
association analyses with diagnosis:codominant P-value = 0....... association analyses with diagnosis:codominant P-value = 0.097, dominant P-value = 0.038, recessive P-value = 0.223, additive P-value = 0.033, all P-value > 0.05 after multiple testing correction. More... No significant association was observed. No significant association was observed. Negative Saus, E.,2010
rs2279020 GABRA1 1(0/0/1) 1
Association analysis:genotype P-value = 0.55, allele P-valu...... Association analysis:genotype P-value = 0.55, allele P-value = 0.58 More... No significant association was observed. No significant association was observed. Negative Horiuchi, Y.,2004
rs4640029 MTERFD3 CRY1 1(0/0/1) 1
X2-tests:allele P-value = 0.295, Model Dominant,...... X2-tests:allele P-value = 0.295, Model Dominant, genotype P-value = 0.048, OR(95%CI)=1.40 (1.00-1.95) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs2336149 PBRM1 1(1/0/0) 1
P-value=0.01088, OR=0.9443 for MDD, P-value=0.00000004847, ...... P-value=0.01088, OR=0.9443 for MDD, P-value=0.00000004847, OR=0.9127 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.14. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs1701946 KLK8 KLK9 1(1/0/0) 1
Genotype frequency (df=2) X2=0.33, P value=0.85 ...... Genotype frequency (df=2) X2=0.33, P value=0.85 . Allele frequency (df=1) X2=0.21, P value=0.65 in Patients with MD vs controls. More... There was no significant difference in genotype or allele d...... There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression. More... Negative Izumi, A., 2008
rs5746826 TBX1 GNB1L 1(0/0/1) 1
X2= 0.005, P-value = 0.943 for affective disord...... X2= 0.005, P-value = 0.943 for affective disorder (BP + MDD) when compared with controls More... None of the nine individual SNPs showed a positive associat...... None of the nine individual SNPs showed a positive association in the 'all affecteds' category. More... Negative Funke, B. H., 2007
rs10207288 ERBB4 1(0/0/1) 1
Chi square test: allele P-value = 0.578, OR=0.946;genotype ...... Chi square test: allele P-value = 0.578, OR=0.946;genotype P-value = 0.796, chi square=0.455 for MDD More... No significant association was observed. No significant association was observed. Negative Chen, P.,2012
rs672607 BCL9 1(1/0/0) 1
Third-Stage Sample:for MDD, allele association P-value = 0....... Third-Stage Sample:for MDD, allele association P-value = 0.001, OR(95%CI)=0.79(0.69-0.90) More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Li, J.,2011(b)
rs2117713 NPAS2 1(0/0/1) 1
X2-tests:allele P-value = 0.01, Model Log-additi...... X2-tests:allele P-value = 0.01, Model Log-additive, genotype P-value = 0.006, OR(95%CI)=1.51 (1.13-2.01) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs3744805 NR1D1 THRA 1(0/0/1) 1
Hardy-Weinberg equilibrium P value=0.783, genotypic P value...... Hardy-Weinberg equilibrium P value=0.783, genotypic P value=0.833, allelic P value=0.768 for MDD. More... No significant association was found with major depressive ...... No significant association was found with major depressive disorder. More... Negative Kishi, T., 2008 (b)
rs16949856 1(0/0/1) 1
Omnibus GWAS Test:P-value = 0.0000362, best-fit model is De...... Omnibus GWAS Test:P-value = 0.0000362, best-fit model is Depressive disorders More... Suggestive association was found. Suggestive association was found. Trend Huang, J.,2010
rs7748266 FKBP5 1(0/0/1) 1
P-value=0.347 P-value=0.347 association analysis for single polymorphisms within FKBP5 ...... association analysis for single polymorphisms within FKBP5 gene More... Negative Szczepankiewicz A., 2014
rs671056 BCL9 1(0/0/1) 1
Third-Stage Sample:for MDD, allele association P-value = 0....... Third-Stage Sample:for MDD, allele association P-value = 0.78, OR(95%CI)=1.03(0.81-1.03) More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(b)
rs3746684 PROKR2 1(0/0/1) 1
chi-square test: 1.total samples:P-value = 0.821(Genotype),...... chi-square test: 1.total samples:P-value = 0.821(Genotype), P-value = 0.600(Allele) in MDD 2. male samples: P-value = 0.277(Genotype), P-value = 0.133(Allele) in MDD 3. female samples: P-value = 0.732(Genotype), P-value = 0.420(Allele) in MDD More... We did not detect any significant association with MDD or B...... We did not detect any significant association with MDD or BP in allele/genotype-wise analysis. More... Negative Kishi, T.,2009(c)
rs1148247 CREM 1(0/0/1) 1
Association analysis:genotype P-value = >0.05;allele P-valu...... Association analysis:genotype P-value = >0.05;allele P-value > 0.05 More... No significant association was observed in MDD. No significant association was observed in MDD. Negative Crisafulli, C.,2012
rs3890379 CSNK1E 1(0/0/1) 1
Chi square test:MAF = 0.14,P-value = 0.69,OR = 0.96 Chi square test:MAF = 0.14,P-value = 0.69,OR = 0.96 No significant association was observed. No significant association was observed. Negative Matsunaga, S.,2012
rs3752826 YWHAE 1(0/0/1) 1
For MDD:allele, OR[95%CI]=1.1[0.97-1.24], P-value = 0.1254,...... For MDD:allele, OR[95%CI]=1.1[0.97-1.24], P-value = 0.1254, P-permutation=0.7886;genotype, P-value = 0.29907, P-permutation=0.9841 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(b)
rs34041110 YWHAE 1(0/0/1) 1
For MDD:allele, OR[95%CI]=1.14[1.01-1.29], P-value = 0.0284...... For MDD:allele, OR[95%CI]=1.14[1.01-1.29], P-value = 0.02843, P-permutation=0.3244;genotype, P-value = 0.06655, P-permutation=0.5703 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(b)
rs10807187 MDGA1 1(0/0/1) 1
Single SNP analyses:allele, P-value = 0.8324, OR[95%CI]=1.0...... Single SNP analyses:allele, P-value = 0.8324, OR[95%CI]=1.0137[0.8937, 1.1498], genotype, P-value = 0.8088 for MDD More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(a)
rs17500692 ADCYAP1 1(1/0/0) 1
X2-tests:allele P-value = 0.038, Model Dominant,...... X2-tests:allele P-value = 0.038, Model Dominant, genotype P-value = 0.021, OR(95%CI)=0.67 (0.47-0.94) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs4774370 RORA 1(1/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs9558575 DAOA DAOA-AS1 1(0/0/1) 1
Armitage's trend test:P-value = 0.95 Armitage's trend test:P-value = 0.95 No significant association was observed. No significant association was observed. Negative Gawlik, M.,2010
rs3738398 DISC1 1(0/0/1) 1
Genotypic P-value = 0.27, allelic P-value = 1.00 Genotypic P-value = 0.27, allelic P-value = 1.00 no significant differences between unipolar disorder and co...... no significant differences between unipolar disorder and controls More... Negative Arai, M., 2007
rs2131431 YWHAE 1(0/0/1) 1
For MDD:allele, OR[95%CI]=1.04[0.90-1.20], P-value = 0.5817...... For MDD:allele, OR[95%CI]=1.04[0.90-1.20], P-value = 0.58175, P-permutation=0.9999;genotype, P-value = 0.59049, P-permutation=0.9999 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(b)
rs2070040 HTR2A 1(0/0/1) 1
chi-square test: 1.total samples:P-value = 0.675(Genotype),...... chi-square test: 1.total samples:P-value = 0.675(Genotype), P-value = 0.394(Allele) in Mood disorders;P-value = 0.884(Genotype), P-value = 0.684(Allele) in MDD 2. male samples: P-value = 0.339(Genotype), P-value = 0.158(Allele) in Mood disorders;P-value = 0.456(Genotype), P-value = 0.214(Allele) in MDD 3. female samples: P-value = 0.982(Genotype), P-value = 0.851(Allele) in Mood disorders;P-value = 0.8182(Genotype), P-value = 0.526(Allele) in MDD More... we did not detect any significant association of HTR2A with...... we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. More... Negative Kishi, T.,2009(b)
rs4131347 TBC1D15 TPH2 1(0/0/1) 1
Genotypic P-value = 0.684, allelic P-value = 0.502 for MDD ...... Genotypic P-value = 0.684, allelic P-value = 0.502 for MDD when compared with controls. More... There were no differences between MDD and healthy volunteer...... There were no differences between MDD and healthy volunteers in genotype or allelic frequency. More... Negative Mann, J. J., 2008
rs4842318 PAWR 1(0/0/1) 1
Hardy-Weinberg equilibrium P value=0.897, genotypic P value...... Hardy-Weinberg equilibrium P value=0.897, genotypic P value=0.726, allelic P value=0.439 for MDD compared with controls. More... No association was detected with schizophrenia or MDD in al...... No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. More... Negative Kishi, T., 2008 (a)
rs4963954 BHLHE41 1(1/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs129974 CREBBP 1(0/0/1) 1
Association analysis:genotype P-value = >0.05;allele P-valu...... Association analysis:genotype P-value = >0.05;allele P-value > 0.05 More... No significant association was observed in MDD. No significant association was observed in MDD. Negative Crisafulli, C.,2012
rs11130317 GLT8D1 GNL3 SNORD69 1(1/0/0) 1
P-value=0.007697, OR=0.9415 for MDD, P-value=0.00000004832,...... P-value=0.007697, OR=0.9415 for MDD, P-value=0.00000004832, OR=0.912 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.13. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs7431209 GSK3B 1(0/0/1) 1
association analyses with diagnosis:codominant P-value = 0....... association analyses with diagnosis:codominant P-value = 0.076, dominant P-value = 0.048, recessive P-value = 0.594, additive P-value = 0.159, all P-value > 0.05 after multiple testing correction. More... No significant association was observed. No significant association was observed. Negative Saus, E.,2010
rs3654 NTRK2 1(0/0/1) 1
For MDD, allele, P-value = 0.054;For Mood, allele, P-value ...... For MDD, allele, P-value = 0.054;For Mood, allele, P-value = 0.0425, OR=1.397, P-value(perm)=0.836 More... No significant association was observed. No significant association was observed. Negative Soronen, P.,2011
rs17005769 PAWR 1(0/0/1) 1
Hardy-Weinberg equilibrium P value=0.313, genotypic P value...... Hardy-Weinberg equilibrium P value=0.313, genotypic P value=0.21, allelic P value=0.261 for MDD compared with controls. More... No association was detected with schizophrenia or MDD in al...... No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. More... Negative Kishi, T., 2008 (a)
rs2239316 CREBBP 1(0/0/1) 1
Association analysis:genotype P-value = >0.05;allele P-valu...... Association analysis:genotype P-value = >0.05;allele P-value > 0.05 More... No significant association was observed in MDD. No significant association was observed in MDD. Negative Crisafulli, C.,2012
rs7090018 FGFR2 1(0/0/1) 1
Allelic association results:P-value = 0.944, Permutated P-v...... Allelic association results:P-value = 0.944, Permutated P-value = 1 More... No significant association was observed in MDD No significant association was observed in MDD Negative Wang, T.,2012
rs1374913 PROK2 1(0/0/1) 1
chi-square test: 1.total samples:P-value = 0.875(Genotype),...... chi-square test: 1.total samples:P-value = 0.875(Genotype), P-value = 0.823(Allele) in MDD 2. male samples: P-value = 0.572(Genotype), P-value = 0.554(Allele) in MDD 3. female samples: P-value = 0.592(Genotype), P-value = 0.305(Allele) in MDD More... We did not detect any significant association with MDD or B...... We did not detect any significant association with MDD or BP in allele/genotype-wise analysis. More... Negative Kishi, T.,2009(c)
rs17014011 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs3829773 CSNK1D SLC16A3 1(0/0/1) 1
Chi square test:MAF = 0.07,P-value = 0.39,OR = 0.87 Chi square test:MAF = 0.07,P-value = 0.39,OR = 0.87 No significant association was observed. No significant association was observed. Negative Matsunaga, S.,2012
rs2070062 CLOCK 1(1/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs4726220 ACTR3B 1(0/1/0) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs2241802 FZD3 RNA5SP259 1(0/0/1) 1
Allelic association:P-value = 0.96 for MDD Allelic association:P-value = 0.96 for MDD No association was observed in MDD. No association was observed in MDD. Negative Hashimoto, R.,2005(b)
rs11130315 PBRM1 1(1/0/0) 1
P-value=0.007335, OR=1.063 for MDD, P-value=0.00000003019, ...... P-value=0.007335, OR=1.063 for MDD, P-value=0.00000003019, OR=1.098 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.7. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs4851392 NPAS2 1(1/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs16840252 CTLA4 1(0/0/1) 1
For MDD:allele, OR[95%CI]=0.9253[0.7769-1.1021], P-value = ...... For MDD:allele, OR[95%CI]=0.9253[0.7769-1.1021], P-value = 0.3841, P-permutation=0.9537;genotype, P-value = 0.3011, P-permutation=0.8963 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(a)
rs11927974 GSK3B 1(0/0/1) 1
association analyses with diagnosis:codominant P-value = 0....... association analyses with diagnosis:codominant P-value = 0.389, dominant P-value = 0.975, recessive P-value = 0.172, additive P-value = 0.909 More... No significant association was observed. No significant association was observed. Negative Saus, E.,2010
rs738149 CSF2RB 1(0/0/1) 1
Single site association analysis:for MDD, allele, OR=1.315,...... Single site association analysis:for MDD, allele, OR=1.315, P-value = 0.001 More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Chen, P.,2011
rs1532976 YWHAE 1(0/0/1) 1
For MDD:allele, OR[95%CI]=1.11[0.99-1.25], P-value = 0.0806...... For MDD:allele, OR[95%CI]=1.11[0.99-1.25], P-value = 0.08061, P-permutation=0.6353;genotype, P-value = 0.2204, P-permutation=0.9506 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(b)
rs7326068 IFT88 1(0/0/1) 1
Omnibus GWAS Test:P-value = 0.00000292, best-fit model is D...... Omnibus GWAS Test:P-value = 0.00000292, best-fit model is Depressive disorders More... Suggestive association was found. Suggestive association was found. Trend Huang, J.,2010
rs2463169 PAWR 1(0/0/1) 1
Hardy-Weinberg equilibrium P value=0.225, genotypic P value...... Hardy-Weinberg equilibrium P value=0.225, genotypic P value=0.402, allelic P value=0.608 for MDD compared with controls. More... No association was detected with schizophrenia or MDD in al...... No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. More... Negative Kishi, T., 2008 (a)
rs135764 CSNK1E 1(0/0/1) 1
Chi square test:MAF = 0.17,P-value = 0.48,OR = 1.08 Chi square test:MAF = 0.17,P-value = 0.48,OR = 1.08 No significant association was observed. No significant association was observed. Negative Matsunaga, S.,2012
rs1001021 MYO18B 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs3087243 CTLA4 1(0/0/1) 1
For MDD:allele, OR[95%CI]=0.9668[0.8323-1.1231], P-value = ...... For MDD:allele, OR[95%CI]=0.9668[0.8323-1.1231], P-value = 0.6588, P-permutation=0.9996;genotype, P-value = 0.5772, P-permutation=0.9972 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(a)
rs6900617 MDGA1 1(0/0/1) 1
Single SNP analyses:allele, P-value = 0.1106, OR[95%CI]=1.1...... Single SNP analyses:allele, P-value = 0.1106, OR[95%CI]=1.1083[0.9768, 1.2575], genotype, P-value = 0.2453 for MDD More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(a)
rs2871042 TBX1 1(0/0/1) 1
X2= 0.033, P-value = 0.856 for affective disord...... X2= 0.033, P-value = 0.856 for affective disorder (BP + MDD) when compared with controls More... None of the nine individual SNPs showed a positive associat...... None of the nine individual SNPs showed a positive association in the 'all affecteds' category. More... Negative Funke, B. H., 2007
rs2238777 TBX1 1(0/0/1) 1
X2= 0.198, P-value = 0.657 for affective disord...... X2= 0.198, P-value = 0.657 for affective disorder (BP + MDD) when compared with controls More... None of the nine individual SNPs showed a positive associat...... None of the nine individual SNPs showed a positive association in the 'all affecteds' category. More... Negative Funke, B. H., 2007
rs231775 CTLA4 1(0/0/1) 1
For MDD:allele, OR[95%CI]=1.0616[0.9359-1.2043], P-value = ...... For MDD:allele, OR[95%CI]=1.0616[0.9359-1.2043], P-value = 0.3525, P-permutation=0.9371;genotype, P-value = 0.115, P-permutation=0.5522 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(a)
rs4912138 HTR6 1(0/0/1) 1
Association analysis:genotype P-value = 0.894, allele P-val...... Association analysis:genotype P-value = 0.894, allele P-value = 0.938 More... No significant association was observed. No significant association was observed. Negative Fukuo, Y.,2010
rs9659997 HTR6 1(0/0/1) 1
Association analysis:genotype P-value = 0.65, allele P-valu...... Association analysis:genotype P-value = 0.65, allele P-value = 0.966 More... No significant association was observed. No significant association was observed. Negative Fukuo, Y.,2010
rs17102287 FGFR2 1(0/0/1) 1
Allelic association results:P-value = 0.346, Permutated P-v...... Allelic association results:P-value = 0.346, Permutated P-value = 0.985 More... No significant association was observed in MDD No significant association was observed in MDD Negative Wang, T.,2012
rs946903 BCL9 ACP6 1(0/0/1) 1
Third-Stage Sample:for MDD, allele association P-value = 0....... Third-Stage Sample:for MDD, allele association P-value = 0.006, OR(95%CI)=0.82(0.71-0.95) More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Li, J.,2011(b)
rs2540352 VIPR2 1(0/0/1) 1
X2-tests:allele P-value = 0.035, Model Dominant,...... X2-tests:allele P-value = 0.035, Model Dominant, genotype P-value = 0.023, OR(95%CI)=0.67 (0.48-0.95) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs7611731 PBRM1 1(1/0/0) 1
P-value=0.01077, OR=1.059 for MDD, P-value=0.00000004995, O...... P-value=0.01077, OR=1.059 for MDD, P-value=0.00000004995, OR=1.096 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.15. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs804831 MDGA1 1(0/0/1) 1
Single SNP analyses:allele, P-value = 0.6245, OR[95%CI]=1.0...... Single SNP analyses:allele, P-value = 0.6245, OR[95%CI]=1.0412[0.8858, 1.2239], genotype, P-value = 0.7732 for MDD More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(a)
rs885861 VIPR2 LINC00689 1(1/0/0) 1
X2-tests:allele P-value = 0.009, Model Recessive...... X2-tests:allele P-value = 0.009, Model Recessive, genotype P-value = 0.004, OR(95%CI)=1.71 (1.18-2.46) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs4140862 ANO2 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs11191454 AS3MT 1(1/0/0) 1
Association analysis:P-value = 0.0000000139,OR(95%CI) = 1.1...... Association analysis:P-value = 0.0000000139,OR(95%CI) = 1.13(1.08–1.18) when five disorders were combined More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
rs909486 CSF2RB 1(0/0/1) 1
Single site association analysis:for MDD, allele, OR=1.17, ...... Single site association analysis:for MDD, allele, OR=1.17, P-value = 0.026 More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Chen, P.,2011
rs11048995 ARNTL2 1(1/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs231777 CTLA4 1(1/0/0) 1
For MDD:allele, OR[95%CI]=0.8736[0.7334-1.0405], P-value = ...... For MDD:allele, OR[95%CI]=0.8736[0.7334-1.0405], P-value = 0.1295, P-permutation=0.5924;genotype, P-value = 0.2679, P-permutation=0.8568 More... No significant association was observed. No significant association was observed. Negative Liu, J,2011(a)
rs529386 GPR50-AS1 MIR4330 GPR50 1(0/0/1) 1
X2 goodness of fit test:P-value > 0.05 X2 goodness of fit test:P-value > 0.05 No significant association was observed. No significant association was observed. Negative Macintyre, D. J.,2010
rs1051375 CACNA1C CACNA1C-AS1 1(1/0/0) 1
genotypic P-value=0.71, X2=0.68, allelic P-value...... genotypic P-value=0.71, X2=0.68, allelic P-value=0.70, OR(95%CI)=0.97(0.83-1.14) More... Neither allele nor genotype frequencies of the three SNPs w...... Neither allele nor genotype frequencies of the three SNPs were significantly different between MDD patients and control subjects. More... Negative Zhang X, 2013
rs1316780 PROK2 1(0/0/1) 1
chi-square test: 1.total samples:P-value = 0.527(Genotype),...... chi-square test: 1.total samples:P-value = 0.527(Genotype), P-value = 0.962(Allele) in MDD 2. male samples: P-value = 0.757(Genotype), P-value = 0.947(Allele) in MDD 3. female samples: P-value = 0.697(Genotype), P-value = 0.870(Allele) in MDD More... We did not detect any significant association with MDD or B...... We did not detect any significant association with MDD or BP in allele/genotype-wise analysis. More... Negative Kishi, T.,2009(c)
rs1561337 PBRM1 1(1/0/0) 1
P-value=0.006834, OR=0.9404 for MDD, P-value=0.0000000283, ...... P-value=0.006834, OR=0.9404 for MDD, P-value=0.0000000283, OR=0.9103 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.4. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs33967311 PBRM1 1(1/0/0) 1
P-value=0.007529, OR=0.9413 for MDD, P-value=0.00000002789,...... P-value=0.007529, OR=0.9413 for MDD, P-value=0.00000002789, OR=0.9105 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.3. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs2287161 CRY1 MTERFD3 1(1/0/0) 1
X2-tests:allele P-value > 0.05, genotype P-value...... X2-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model More... No significant association was observed. No significant association was observed. Negative Soria, V.,2010
rs130021 CREBBP 1(0/0/1) 1
Association analysis:genotype P-value = >0.05;allele P-valu...... Association analysis:genotype P-value = >0.05;allele P-value > 0.05 More... No significant association was observed in MDD. No significant association was observed in MDD. Negative Crisafulli, C.,2012
rs11610949 ARNTL2 1(1/0/0) 1
X2-tests:allele P-value = 0.043, Model Log-addit...... X2-tests:allele P-value = 0.043, Model Log-additive, genotype P-value = 0.018, OR(95%CI)=0.65 (0.46-0.94) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs1883901 MDGA1 1(1/0/0) 1
Single SNP analyses:allele, P-value = 0.0463(0.4825), OR[95...... Single SNP analyses:allele, P-value = 0.0463(0.4825), OR[95%CI]=1.1676[1.0025, 1.3599], genotype, P-value = 0.1073 for MDD More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(a)
rs714359 MTERFD3 CRY1 1(0/0/1) 1
X2-tests:allele P-value = 0.032, Model Dominant,...... X2-tests:allele P-value = 0.032, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.70 (0.51-0.95) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs12487957 GRM2 1(0/0/1) 1
For MDD:Genotypic association:P-value = 0.579, allelic asso...... For MDD:Genotypic association:P-value = 0.579, allelic association:P-value = 0.91 More... No significant association was observed No significant association was observed Negative Tsunoka, T.,2009
rs9394309 FKBP5 1(0/0/1) 1
P-value=0.018 P-value=0.018 Our main finding is an association of FKBP5 polymorphisms (...... Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. More... Positive Szczepankiewicz A., 2014
rs5748425 TBX1 GNB1L 1(0/0/1) 1
For MDD, chi square test:allele P-value = 0.9845 For MDD, chi square test:allele P-value = 0.9845 No significant association was observed. No significant association was observed. Negative Li, Y.,2011
rs7280842 SAMSN1 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs12487591 PBRM1 1(1/0/0) 1
P-value=0.006943, OR=1.063 for MDD, P-value=0.00000003091, ...... P-value=0.006943, OR=1.063 for MDD, P-value=0.00000003091, OR=1.098 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.9. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs747226 TBX1 1(0/0/1) 1
X2= 0.191, P-value = 0.662 for affective disord...... X2= 0.191, P-value = 0.662 for affective disorder (BP + MDD) when compared with controls More... None of the nine individual SNPs showed a positive associat...... None of the nine individual SNPs showed a positive association in the 'all affecteds' category. More... Negative Funke, B. H., 2007
rs9326555 BCL9 1(0/0/1) 1
Third-Stage Sample:for MDD, allele association P-value = 0....... Third-Stage Sample:for MDD, allele association P-value = 0.99, OR(95%CI)=1.00(0.81-1.23) More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(b)
rs9533042 DGKH 1(0/0/1) 1
Allelic association:P-value > 0.05 for MDD. Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs839523 ERBB4 1(0/0/1) 1
Chi square test: allele P-value = 0.555, OR=1.037;genotype ...... Chi square test: allele P-value = 0.555, OR=1.037;genotype P-value = 0.837, chi square=0.357 for MDD More... No significant association was observed. No significant association was observed. Negative Chen, P.,2012
rs130005 CREBBP 1(0/0/1) 1
Association analysis:genotype P-value = >0.05;allele P-valu...... Association analysis:genotype P-value = >0.05;allele P-value > 0.05 More... No significant association was observed in MDD. No significant association was observed in MDD. Negative Crisafulli, C.,2012
rs3821829 GRM2 TEX264 1(0/0/1) 1
For MDD:Genotypic association:P-value = 0.869, allelic asso...... For MDD:Genotypic association:P-value = 0.869, allelic association:P-value = 0.924 More... No significant association was observed No significant association was observed Negative Tsunoka, T.,2009
rs352203 FZD3 1(0/0/1) 1
Allelic association:P-value = 0.64 for MDD Allelic association:P-value = 0.64 for MDD No association was observed in MDD. No association was observed in MDD. Negative Hashimoto, R.,2005(b)
rs12133766 DISC1 1(0/0/1) 1
genotypic/allelic test P-value: 0.69/0.60 genotypic/allelic test P-value: 0.69/0.60 No significant genotypic or allelic association was observe...... No significant genotypic or allelic association was observed. More... Negative Schosser, A., 2010
rs194487 CTNND2 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs4765914 CACNA1C 1(1/0/0) 1
Association analysis:P-value = 0.0000000152 when BPD,MDD an...... Association analysis:P-value = 0.0000000152 when BPD,MDD and SZ were combined. More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
rs2371276 ERBB4 1(0/0/1) 1
Chi square test: allele P-value = 0.062, OR=1.174;genotype ...... Chi square test: allele P-value = 0.062, OR=1.174;genotype P-value = 0.176, chi square=3.472 for MDD More... No significant association was observed. No significant association was observed. Negative Chen, P.,2012
rs7769372 MDGA1 1(0/0/1) 1
Single SNP analyses:allele, P-value = 0.8802, OR[95%CI]=0.9...... Single SNP analyses:allele, P-value = 0.8802, OR[95%CI]=0.9904[0.8732, 1.1232], genotype, P-value = 0.9888 for MDD More... No significant association was observed. No significant association was observed. Negative Li, J.,2011(a)
rs2981578 FGFR2 1(0/0/1) 1
Allelic association results:P-value = 0.661, Permutated P-v...... Allelic association results:P-value = 0.661, Permutated P-value = 1 More... No significant association was observed in MDD No significant association was observed in MDD Negative Wang, T.,2012
rs12496634 PBRM1 1(1/0/0) 1
P-value=0.007207, OR=1.063 for MDD, P-value=0.00000003439, ...... P-value=0.007207, OR=1.063 for MDD, P-value=0.00000003439, OR=1.098 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.12. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs11133379 CLOCK TMEM165 1(0/0/1) 1
X2-tests:allele P-value = 0.167, Model Recessive...... X2-tests:allele P-value = 0.167, Model Recessive, genotype P-value = 0.046, OR(95%CI)=1.53 (1.01-2.32) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs2268026 NEK4 1(1/0/0) 1
P-value=0.007732, OR=1.063 for MDD, P-value=0.00000003412, ...... P-value=0.007732, OR=1.063 for MDD, P-value=0.00000003412, OR=1.099 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded gen...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.11. More... Positive Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013
rs231779 CTLA4 1(1/0/0) 1
For MDD:allele, OR[95%CI]=1.2515[1.1015-1.4218], P-value = ...... For MDD:allele, OR[95%CI]=1.2515[1.1015-1.4218], P-value = 0.0006, P-permutation=0.001;genotype, P-value = 0.0026, P-permutation=0.0201 More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Liu, J,2011(a)
rs5746832 TBX1 GNB1L 1(1/0/0) 1
For MDD, chi square test:allele P-value = 0.0137 For MDD, chi square test:allele P-value = 0.0137 Significant association was observed in MDD. Significant association was observed in MDD. Positive Li, Y.,2011
rs7678609 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs1541187 BCL9 1(0/0/1) 1
Third-Stage Sample:for MDD, allele association P-value = 0....... Third-Stage Sample:for MDD, allele association P-value = 0.04, OR(95%CI)=1.23(1.01-1.52) More... Significant association was observed in MDD. Significant association was observed in MDD. Positive Li, J.,2011(b)
rs12670064 VIPR2 1(1/0/0) 1
X2-tests:allele P-value = 0.157, Model Dominant,...... X2-tests:allele P-value = 0.157, Model Dominant, genotype P-value = 0.044, OR(95%CI)=0.73 (0.53-0.99) More... Significant association was found. Significant association was found. Positive Soria, V.,2010
rs17101921 FGFR2 1(0/0/1) 1
Allelic association results:P-value = 0.675, Permutated P-v...... Allelic association results:P-value = 0.675, Permutated P-value = 1 More... No significant association was observed in MDD No significant association was observed in MDD Negative Wang, T.,2012
rs278865 NR4A2 1(0/0/1) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs135745 CSNK1E 1(0/0/1) 1