SNP Report

Basic Info

Name	rs28536160 dbSNP Ensembl
Location	chr1:206117948 - 206117948(1)
Variant Alleles	A/G
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.188898
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000425896); non_coding_transcript_variant(ENST00000425896); upstream_gene_variant(ENST00000367126, ENST00000612906)
No. of Studies	3 (Positive: 1; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Szczepankiewicz, A., 2013	C/T	allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 95...... allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 95% CI=0.607-1.067 for affective disorder; allelic P-value=0.062, genotypic P-value=0.056, OR=1.388, 95% CI=0.999-1.888 for BD More...	In the single marker association analysis of AVPR1b gene we ...... In the single marker association analysis of AVPR1b gene we observed an association of rs28536160 with mood disorders (P=0.036); this was not observed in the bipolar disorder and MDD patients separately. More...	Negative
Leszczynska-Rodziewicz, A., 2012	C/T	genotypic P-value = 0.04 genotypic P-value = 0.04	We found an association between TT genotype of rs28536160 po...... We found an association between TT genotype of rs28536160 polymorphism of the AVPR1b gene and bipolar disorder with psychotic features for T allele. More...	Positive
Leszczynska-Rodziewicz A, 2013	C/T	P-value=0.30 P-value=0.30	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
AVPR1B	arginine vasopressin receptor 1B	1q32	4(3/1/0)

SNPs in LD with rs28536160 (count: 0) View in gBrowse (chr1:206117948..206117948 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A., 2013	allelic P-value=0.149, genotypic P-value=0.036, OR=0.804, 95% CI=0.607-1.067 for affective disorder; allelic P-value=1, genotypic P-value=0.387, OR=1.001, 95% CI=0.662-1.514 for MDD	In the single marker association analysis of AVPR1b gene we observed an association of rs28536160 with mood disorders (P=0.036); this was not observed in the bipolar disorder and MDD patients separately.	Negative