BDgene

SNP Report

Basic Info
Name rs6198 dbSNP Ensembl
Location chr5:143278056 - 143278056(1)
Variant Alleles T/C
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.0838658
Functional Annotation 3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript 3_prime_UTR_variant(ENST00000343796, ENST00000394464, ENST00000415690); downstream_gene_variant(ENST00000231509, ENST00000394466, ENST00000424646, ENST00000503201, ENST00000504572)
No. of Studies 4 (Positive: 0; Negative: 4; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Leszczynska-Rodziewicz, A., 2012 C/T genotypic P-value = 0.69 genotypic P-value = 0.69 There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More... Negative
Szczepankiewicz, A.,2011 C/T For BD, X2 test: allele, P-value > 0.05; the Fish...... For BD, X2 test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.028 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Spijker, A. T.,2009 A/G Genotypic association: OR = 0.76, 95% CI: 0.5-1.0, P-value =...... Genotypic association: OR = 0.76, 95% CI: 0.5-1.0, P-value = 0.14, corrected for age and gender; for age: OR = 1.04, 95% CI: 1.02-1.05, P-value = 0.000; for male gender: OR = 0.52, 95% CI: 0.37-0.72, P-value < 0.0001 More... We found a nonsignificant trend for a lower frequency of the...... We found a nonsignificant trend for a lower frequency of the A ?G or G ?G variation in exon 9beta in the patient group versus the control group. More... Negative
Leszczynska-Rodziewicz A, 2013 C/T P-value=0.65 P-value=0.65 Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0)

SNPs in LD with rs6198 (count: 6) View in gBrowse (chr5:143277456..143382248 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 6)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Szczepankiewicz, A.,2011 X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value = 0.018, df=2, X2=7.964, OR=0.950, 95% CI: 0.693-1.303. Significant association was found. Positive