BDgene

SNP Report

Basic Info
Name rs1487275 dbSNP Ensembl
Location chr12:72016512 - 72016512(1)
Variant Alleles C/A
Ancestral Allele A
Minor Allele C
Minor Allele Frequence 0.322085
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000333850)
No. of Studies 5 (Positive: 0; Negative: 5; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Cichon, S., 2008 T/G G Cochrane-Armitage trend test P-value > .0.5 in the German BP...... Cochrane-Armitage trend test P-value > .0.5 in the German BPAD sample. Cochrane-Armitage trend test P-value > .0.5 in the Russian BPAD sample. Cochrane-Armitage trend test P-value > .0.5 in Combined German/Russian sample. More... Negative
Van Den Bogaert, A., 2006 (a) A/C genotypic P-value = 0.83, allelic P-value = 0.82 genotypic P-value = 0.83, allelic P-value = 0.82 Negative
Campos, S. B., 2010 The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More... Negative
Roche, S.,2009 G TDT: X2=2.571, P-value = 0.1088 TDT: X2=2.571, P-value = 0.1088 No significant association was observed No significant association was observed Negative
Grigoroiu-Serbanescu, M.,2008 T/G Cochrane-Armitage trend test P value=0.537 Cochrane-Armitage trend test P value=0.537 Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0)

SNPs in LD with rs1487275 (count: 0) View in gBrowse (chr12:72016512..72016512 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Van Den Bogaert, A., 2006 (a) genotypic P-value = 0.57, allelic P-value = 0.53 Negative