BDgene

SNP Report

Basic Info
Name rs11130317 dbSNP Ensembl
Location chr3:52697467 - 52697467(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.319888
Functional Annotation downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000391150, ENST00000394799, ENST00000418458, ENST00000464705, ENST00000484022, ENST00000487642, ENST00000496254, ENST00000497356, ENST00000497436, ENST00000497953); intron_variant(ENST00000266014, ENST00000394783, ENST00000463827, ENST00000478968, ENST00000479553, ENST00000484163, ENST00000485899, ENST00000489119, ENST00000491606); non_coding_transcript_variant(ENST00000463827, ENST00000484163, ENST00000485899); upstream_gene_variant(ENST00000480080, ENST00000481643)
No. of Studies 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 P-value=0.0000001963, OR=0.876 for BIP, P-value=0.0000000483...... P-value=0.0000001963, OR=0.876 for BIP, P-value=0.00000004832, OR=0.912 for combined sample More... In the combined analysis of these 819 SNPs, 15 exceeded geno...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.13. More... Positive

SNP related genes (count: 3)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
GLT8D1 glycosyltransferase 8 domain containing 1 3p21.1 1(1/0/0)
SNORD69 small nucleolar RNA, C/D box 69 3p21.1 Mapped by Literature SNP
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 3p21.1 2(2/0/0)

SNPs in LD with rs11130317 (count: 0) View in gBrowse (chr3:52697467..52697467 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013 P-value=0.007697, OR=0.9415 for MDD, P-value=0.00000004832, OR=0.912 for combined sample In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.13. Positive