Study Report
Basic Info
| Reference |
Kishi, T.,2009(b) PMID: 19428704
|
| Citation |
Kishi, T., T. Kitajima, et al. (2009). Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population. Neurosci Res 64(2): 231-234.
|
| Disease Type |
Bipolar Disorder & Major Depressive Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
325 MDD patients, 155 BP patients(96 patients with bipolar I disorder and 59 patients with bipolar II disorder) and 802 controls |
| SNP/Region/Marker Size |
4 SNPs |
| Predominant Ethnicity |
Mongloid |
| Population |
Japanese |
| Gender |
BP patients:80 males and 75 females;MDD patients:159 males and 166 females and healthy controls:351 males and 451 females |
| Age Group |
Adults
:
mean age(year):BP patients:47.9(SD=14.2);MDD patients:47.3(SD=14.9) and healthy controls:37.6(SD=14.3)
|
Detail Info
| Sample Diagnosis |
DSM |
| Sample Status |
All subjects were unrelated to one another, ethnically Japanese, and lived in the central area of Japan. The patients were diagnosed according to DSM-IV criteria with consensus of at least two experienced psychiatrists on the basis of unstructured interviews and a review of medical records. All healthy controls were also psychiatrically screened based on unstructured interviews. None had severe medical complications such as cirrhosis, renal failure, heart failure or other Axis-I disorders according to DSM-IV. This study was approved by the Ethics Committee at Fujita Health University and Nagoya University School of Medicine. |
| Technique |
genotyping |
| Statistical Method |
chi-square test and likelihood ratio test |
| Result Summary |
We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis. In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and mood disorders in the Japanese population, but sample sizes, especially BP, were probably too small to allow a meaningful test. |
Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 4)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs1928040 |
HTR2A
|
T/C |
|
chi-square test: 1.total samples: P-value = 0.287(Genotype), P-value = 0.182(Allele) in BP 2. male samples: P-value = 0.592(Genotype), P-value = 0.307(Allele) in BP 3. female samples: P-value = 0.436(Genotype), P-value = 0.374(Allele) in BP
|
No significant association was observed
No significant association was observed
|
Negative
|
| rs7997012 |
HTR2A
|
G/A |
|
chi-square test: 1.total samples: P-value = 0.591(Genotype), P-value = 0.325(Allele) in BP 2. male samples: P-value = 0.869(Genotype), P-value = 0.971(Allele) in BP 3. female samples: P-value = 0.357(Genotype), P-value = 0.163(Allele) in BP
|
No significant association was observed
No significant association was observed
|
Negative
|
| rs6313 |
HTR2A
|
T/C |
|
chi-square test: 1.total samples: P-value = 0.172(Genotype), P-value = 0.104(Allele) in BP 2. male samples: P-value = 0.533(Genotype), P-value = 0.324(Allele) in BP 3. female samples: P-value = 0.0643(Genotype), P-value = 0.208(Allele) in BP
|
No significant association was observed
No significant association was observed
|
Negative
|
| rs2070040 |
HTR2A
|
A/G |
|
chi-square test: 1.total samples: P-value = 0.559(Genotype), P-value = 0.273(Allele) in BP 2. male samples: P-value = 0.582(Genotype), P-value = 0.345(Allele) in BP 3. female samples: P-value = 0.786(Genotype), P-value = 0.522(Allele) in BP
|
No significant association was observed
No significant association was observed
|
Negative
|
Haplotypes reported by this study for BD (count: 1)
| Markers |
Haplotype |
Related Gene(s)/Region(s) |
Statistical Values |
Author Comments |
Result Category |
| rs6313 - rs2070040 - rs1928040 - rs7997012 |
|
HTR2A
|
likelihood ratio test:Global P-value = 0.344 in BP
|
No significant association was found with BP.
No significant association was found with BP.
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| HTR2A |
In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and M......
In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and MDD and BP, but sample sizes (especially BP) were probably too small to allow a meaningful test.
More...
|
Negative
|
Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
| Disease |
SNP |
Related Gene(s) |
Statistical Values |
Description |
Result Category |
| MDD |
rs6313 |
HTR2A
|
chi-square test: 1.total samples:P-value = 0.430(Genotype), P-value = 0.254(Allele) in Mood disorders;P-value = 0.883(Genotype), P-value = 0.656(Allele) in MDD 2. male samples: P-value = 0.424(Genotype), P-value = 0.240(Allele) in Mood disorders;P-value = 0.616(Genotype), P-value = 0.361(Allele) in MDD 3. female samples: P-value = 0.310(Genotype), P-value = 0.731(Allele) in Mood disorders;P-value = 0.763(Genotype), P-value = 0.732(Allele) in MDD |
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. |
Negative
|
| MDD |
rs2070040 |
HTR2A
|
chi-square test: 1.total samples:P-value = 0.675(Genotype), P-value = 0.394(Allele) in Mood disorders;P-value = 0.884(Genotype), P-value = 0.684(Allele) in MDD 2. male samples: P-value = 0.339(Genotype), P-value = 0.158(Allele) in Mood disorders;P-value = 0.456(Genotype), P-value = 0.214(Allele) in MDD 3. female samples: P-value = 0.982(Genotype), P-value = 0.851(Allele) in Mood disorders;P-value = 0.8182(Genotype), P-value = 0.526(Allele) in MDD |
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. |
Negative
|
| MDD |
rs1928040 |
HTR2A
|
chi-square test: 1.total samples:P-value = 0.894(Genotype), P-value = 0.888(Allele) in Mood disorders;P-value = 0.370(Genotype), P-value = 0.499(Allele) in MDD 2. male samples: P-value = 0.929(Genotype), P-value = 0.977(Allele) in Mood disorders;P-value = 0.623(Genotype), P-value = 0.524(Allele) in MDD 3. female samples: P-value = 0.930(Genotype), P-value = 0.837(Allele) in Mood disorders;P-value = 0.551(Genotype), P-value = 0.771(Allele) in MDD |
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. |
Negative
|
| MDD |
rs7997012 |
HTR2A
|
chi-square test: 1.total samples:P-value = 0.781(Genotype), P-value = 0.518(Allele) in Mood disorders;P-value = 0.336(Genotype), P-value = 0.149(Allele) in MDD 2. male samples: P-value = 0.317(Genotype), P-value = 0.414(Allele) in Mood disorders;P-value = 0.236(Genotype), P-value = 0.293(Allele) in MDD 3. female samples: P-value = 0.703(Genotype), P-value = 0.874(Allele) in Mood disorders;P-value = 0.374(Genotype), P-value = 0.297(Allele) in MDD |
we did not detect any significant association of HTR2A with MDD or BP in allele/genotype-wise analysis. |
Negative
|
Haplotypes reported by this study for SZ/MDD
| Disease |
Markers |
Haplotype |
Related Gene(s)/Region(s) |
Statistical Values |
Description |
Result Category |
| MDD |
rs6313 - rs2070040 - rs1928040 - rs7997012 |
|
HTR2A
|
likelihood ratio test:Global P-value = 0.198 in MDD, Global P-value = 0.0810 in mood disorders group |
No significant association was found with MDD. |
Negative
|
Genes reported by this study for SZ/MDD
| Disease |
Gene |
Description |
Result Category |
| MDD |
HTR2A |
In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and MDD and BP, but sample sizes(especially BP) were probably too small to allow a meaningful test. |
Negative |
