SNP Report

Basic Info

Name	rs12487957 dbSNP Ensembl
Location	chr3:51720100 - 51720100(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.128195
Functional Annotation	downstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000296479, ENST00000395052, ENST00000442933, ENST00000464585, ENST00000475478)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Tsunoka, T.,2009	T/C	T	For BP: Genotypic association: P-value = 0.148, allelic asso...... For BP: Genotypic association: P-value = 0.148, allelic association: P-value = 0.0719 More...	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GRM2	glutamate receptor, metabotropic 2	3p21.2	1(0/1/0)

SNPs in LD with rs12487957 (count: 5) View in gBrowse (chr3:51542948..51727237 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs2132914		0.945[CHB]; 1.0[JPT]
rs4687770	downstream_gene_variant	0.8[CHD]
rs17051811	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.932[CHB]; 1.0[JPT]
rs4687592	intron_variant; non_coding_transcript_variant	1.0[CHB]; 0.974[CHD]; 1.0[JPT]
rs4687599	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Tsunoka, T.,2009	For MDD:Genotypic association:P-value = 0.579, allelic association:P-value = 0.91	No significant association was observed	Negative