Gene Report

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Basic Info

Approved Symbol	PROK2
Symbol Alias	PK2, BV8, MIT1, KAL4
Approved Name	prokineticin 2
Name Alias	protein Bv8 homolog
Location	3p21.1
Position	chr3:71771656-71785206, -1
External Links	HGNC: 18455 Entrez Gene: 60675 Ensembl: ENSG00000163421 UCSC: uc003dpa.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kishi, T.,2009(c)	SNP: rs10865660, rs1316780, rs1374913, rs3796224 Haplotype: rs1316780 - rs10865660 - rs3796224 - rs1374913()	In this study, we could detect no evidence of genetic association between PROK2 and BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006954	inflammatory response	biological process	NAS[11259612]	23

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001525	angiogenesis	biological process	IDA[12604792]	20
GO:0007186	G-protein coupled receptor signaling pathway	biological process	NAS[11259612]	64
GO:0005576	extracellular region	cellular component	TAS[12466223]	97
GO:0007283	spermatogenesis	biological process	IMP[10580115]	29
GO:0019233	sensory perception of pain	biological process	TAS[12728244]	15
GO:0008283	cell proliferation	biological process	IDA[12604792]	37
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	TAS[12728244]	21
GO:0007623	circadian rhythm	biological process	IEA	40
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18
GO:0045987	positive regulation of smooth muscle contraction	biological process	IDA[11259612]	3
GO:0001664	G-protein coupled receptor binding	molecular function	TAS[12728244]	9
GO:0000187	activation of MAPK activity	biological process	TAS[12728244]	14
GO:0006935	chemotaxis	biological process	IDA[12604792]	7
GO:0043066	negative regulation of apoptotic process	biological process	IDA[12604792]	46

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1316780	chr3:71788084 - 71788084(1)	upstream_gene_variant	1(0/1/0)
rs10865660	chr3:71780868 - 71780868(1)	intron_variant	1(0/1/0)
rs1374913	chr3:71762947 - 71762947(1)		1(0/1/0)
rs3796224	chr3:71774431 - 71774431(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs2322143	chr3:71776722 - 71776722(1)	intron_variant
rs7644362	chr3:71780091 - 71780091(1)	intron_variant
rs7634474	chr3:71780316 - 71780316(1)	intron_variant
rs1320015	chr3:71779269 - 71779269(1)	intron_variant
rs10779992	chr3:71780763 - 71780763(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD
19544013	In this study, we could detect no evidence of genetic association between PROK2 and MDD.	Negative

Reference	Description	Category in MDD	Link in MK4MDD
20471630	Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD	Pos	PROK2

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Region: chr3:71771656..71785206 View in gBrowse