SNP Report

Basic Info

Name	rs956572 dbSNP Ensembl
Location	chr18:63153338 - 63153338(1)
Variant Alleles	A/G
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.349042
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000333681, ENST00000398117, ENST00000590515); non_coding_transcript_variant(ENST00000590515); upstream_gene_variant(ENST00000587475)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Soeiro-de-Souza, M. G., 2013			allelic P-value=0.24, genotypic P-value=0.6 allelic P-value=0.24, genotypic P-value=0.6	The Bcl-2 genotype distribution in the experimental sample w...... The Bcl-2 genotype distribution in the experimental sample was in accordance with the Hardy-Weinberg equilibrium, and genotype and allele A frequency did not differ between BD and control group. More...	Negative
Uemura, T.,2011	A/G		chi-square tests: genotype, BD-I (P-value = 0.79, X^{2 chi-square tests: genotype, BD-I (P-value = 0.79, X²=0.47), BD-II(P-value = 0.79, X²=0.46); allele, BD-I [P-value = 0.58; odds ratio (OR) = 1.12, 95% confidence interval (CI): 0.74-1.69, X²=0.24], BD-II (P-value = 0.62; OR = 1.12, 95%CI: 0.69-1.83, X²=0.31) More...}	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
BCL2	B-cell CLL/lymphoma 2	18q21.3	2(0/2/0)

SNPs in LD with rs956572 (count: 0) View in gBrowse (chr18:63153338..63153338 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Uemura, T.,2011	chi-square tests:genotype, MDD(P-value = 0.31, X²=2.32);allele, MDD[P-value = 0.89;OR = 0.95, 95% CI:(0.52-1.75), X²=0.02]	No significant association was observed.	Negative