SNP Report

Basic Info

Name	rs28632197 dbSNP Ensembl
Location	chr1:206110373 - 206110373(1)
Variant Alleles	C/A/T
Ancestral Allele	C
Minor Allele	A
Minor Allele Frequence	0.11861
Functional Annotation	missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant. Polyphen Annotation: benign(ENST00000367126) SIFT Annotation: tolerated(ENST00000367126)
Consequence to Transcript	missense_variant(ENST00000367126); non_coding_transcript_exon_variant(ENST00000612906); non_coding_transcript_variant(ENST00000612906)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Leszczynska-Rodziewicz A, 2013	A/G	P-value=0.43 P-value=0.43	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
Szczepankiewicz, A., 2013	A/G	allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 95...... allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 95% CI=0.763-1.244 for affective disorder; allelic P-value=0.631, genotypic P-value=0.556, OR=1.088, 95% CI=0.780-1.336 for BD More...	No significant association was observed. No significant association was observed.	Negative
Leszczynska-Rodziewicz, A., 2012	A/G	genotypic P-value = 0.59 genotypic P-value = 0.59	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
AVPR1B	arginine vasopressin receptor 1B	1q32	4(3/1/0)

SNPs in LD with rs28632197 (count: 0) View in gBrowse (chr1:206110373..206110373 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A., 2013	allelic P-value=0.883, genotypic P-value=0.824, OR=0.974, 95% CI=0.763-1.244 for affective disorder; allelic P-value=0.397, genotypic P-value=0.353, OR=0.853, 95% CI=0.597-1.219 for MDD	No significant association was observed.	Negative