SNP Report

Basic Info

Name	rs28373064 dbSNP Ensembl
Location	chr1:206117775 - 206117775(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	G
Minor Allele Frequence	0.20008
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000367126, ENST00000425896, ENST00000612906)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Szczepankiewicz, A., 2013	A/G	allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 95...... allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 95% CI=0.766-1.119 for affective disorder; allelic P-value=0.19, genotypic P-value=0.332, OR=0.859, 95% CI=0.702-1.067 for BD More...	No significant association was observed. No significant association was observed.	Negative
Leszczynska-Rodziewicz, A., 2012	A/G	genotypic P-value = 0.33 genotypic P-value = 0.33	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative
Leszczynska-Rodziewicz A, 2013	A/G	P-value=0.13 P-value=0.13	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
AVPR1B	arginine vasopressin receptor 1B	1q32	4(3/1/0)

SNPs in LD with rs28373064 (count: 1) View in gBrowse (chr1:206117775..206122388 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs28750713		intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.906[CEU]; 0.928[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A., 2013	allelic P-value=0.454, genotypic P-value=0.706, OR=0.926, 95% CI=0.766-1.119 for affective disorder; allelic P-value=0.514, genotypic P-value=0.399, OR=1.099, 95% CI=0.830-1.454 for MDD	No significant association was observed.	Negative