BDgene

Study Report

Basic Info
Reference
Citation Szczepankiewicz, A., et al. (2014). "FKBP5 polymorphism is associated with major depression but not with bipolar disorder." J Affect Disord 164: 33-37.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Genetic interaction study
Sample Size 528 bipolar patients, 218 patients with major depressive disorder and 742 subjects from control group
SNP/Region/Marker Size 8 SNPs
Predominant Ethnicity Caucasian
Population Wielkopolska
Gender BD: 41.8% male of 528 BD patients; MDD: 23.0% male of 218 MDD patients; Controls: 42.5% male of 742 controls.
Age Group adults : BD: mean=44.36, SD=13.9; MDD: mean=45.5, SD=14.0; Controls: mean=37.7, SD=12.5

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 8)

Haplotypes reported by this study for BD (count: 7)

Genes reported by this study for BD (count: 1)

Gene-gene interactions reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
MDD rs3800373 FKBP5 P-value=0.083 association analysis for single polymorphisms within FKBP5 gene Negative
MDD rs9394309 FKBP5 P-value=0.018 Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. Positive
MDD rs9296158 FKBP5 P-value=0.03 Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. Positive
MDD rs7748266 FKBP5 P-value=0.347 association analysis for single polymorphisms within FKBP5 gene Negative
MDD rs4713916 FKBP5 P-value=0.038 Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. Positive
MDD rs9470080 FKBP5 P-value=0.007 Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. Positive
MDD rs755658 FKBP5 P-value=0.46 association analysis for single polymorphisms within FKBP5 gene Negative
MDD rs1360780 FKBP5 P-value=0.011 Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. Positive

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 C-C-A-T-T-G-T FKBP5 P-value=0.510 No significant association was observed. Negative
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 A-C-G-C-C-A-C FKBP5 P-value=0.130 No significant association was observed. Negative
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 C-T-A-C-T-G-T FKBP5 P-value=0.334 No significant association was observed. Negative
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 A-C-G-C-C-G-T FKBP5 P-value=0.430 No significant association was observed. Negative
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 C-C-A-C-T-A-T FKBP5 P-value=0.043 haplotypes CCACTAT was significantly more frequent in the patients with major depressive disorder as compared to the healthy subjects (p=0.043). Positive
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 C-C-A-C-T-G-T FKBP5 P-value=0.608 No significant association was observed. Negative
MDD rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373 A-C-A-T-T-G-T FKBP5 P-value=0.014 haplotypes ACATTGT was significantly more frequent in the patients with major depressive disorder as compared to the healthy subjects (p=0.014). Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD FKBP5 Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder. Positive