SNP Report

Basic Info

Name	rs714359 dbSNP Ensembl
Location	chr12:106985067 - 106985067(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.190495
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000547115); intron_variant(ENST00000240050, ENST00000392830, ENST00000548101, ENST00000550496, ENST00000550736, ENST00000552029)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Soria, V.,2010			X²-tests: allele P-value > 0.05, genotype P-value...... X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CRY1	cryptochrome circadian clock 1	12q23-q24.1	2(1/1/0)
MTERFD3	mitochondrial transcription termination factor 2	12q24.1	Mapped by Literature SNP

SNPs in LD with rs714359 (count: 1) View in gBrowse (chr12:106985067..106987127 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs2287162		5_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	0.839[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Soria, V.,2010	X²-tests:allele P-value = 0.032, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.70 (0.51-0.95)	Significant association was found.	Positive