SNP Report

Basic Info

Name	rs6465084 dbSNP Ensembl
Location	chr7:86774159 - 86774159(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.225439
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000423979); intron_variant(ENST00000361669, ENST00000439827, ENST00000454217)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Dalvie, S.,2010			SNP Allele Frequencies: logistic regression, for Caucasian, ...... SNP Allele Frequencies: logistic regression, for Caucasian, , Mixed Ancestry, P-value = 0.5953; for Caucasian only, P-value = 0.3054; for Mixed Ancestry only, P-value = 0.7887 More...	No significant association was observed in BP-I. No significant association was observed in BP-I.	Negative
Tsunoka, T.,2009	A/G	A	For BP: Genotypic association: P-value = 0.896, allelic asso...... For BP: Genotypic association: P-value = 0.896, allelic association: P-value = 0.722 More...	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GRM3	glutamate receptor, metabotropic 3	7q21.1-q21.2	7(3/4/0)

SNPs in LD with rs6465084 (count: 0) View in gBrowse (chr7:86774159..86774159 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Tsunoka, T.,2009	For MDD:Genotypic association:P-value = 0.0344, allelic association:P-value = 0.00928	We found an association between rs6465084 in GRM3 and MDD in the allele-wise analysis after Bonferroni's correction.	Positive