Study Report
Basic Info
| Reference |
Uemura, T.,2011 PMID: 21320251
|
| Citation |
Uemura, T., M. Green, et al. (2011). "Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder." Bipolar Disord 13(1): 41-51.
|
| Disease Type |
Bipolar Disorder & Major Depressive Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
patients with bipolar I disorder (BD-I) (n=150), bipolar II disorder (BD-II) (n=65), and major depressive disorder (n=30) patients, and from healthy subjects (n=70) |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
|
| Population |
Canadian |
| Gender |
Male/female:9/21 in MDD patients;23/42 in BD-II patients;54/96 in BD-I patients;35/35 in healthy subjects |
| Age Group |
Adults
:
Mean age(SD)(year):40.3(12.7)[26.1(12.1) at onset] in MDD patients;36.0(10.5)[18.1(7.5) at onset] in BD-II patients;37.5(11.1)[22.0(13.8) at onset]in BD-I patients;38.8(11.0) in healthy subjects
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Detail Info
| Sample Diagnosis |
DSM |
| Technique |
PCR and sequencing |
| Statistical Method |
two-tailed chi-square tests |
| Result Summary |
No significant differences were observed in the genotype frequencies compared with healthy subjects among BD-I (p = 0.79), BD-II(p = 0.79), or MDD patients (p = 0.31).Similarly, allele frequencies were not significantly different in BD-I [p = 0.58; odds ratio (OR) = 1.12, 95% confidence interval (CI):0.74-1.69], BD-II (p = 0.62; OR = 1.12, 95%CI: 0.69-1.83), or MDD patients (p = 0.89;OR = 0.95, 95% CI: 0.52-1.75). |
Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 1)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs956572 |
BCL2
|
A/G |
|
chi-square tests: genotype, BD-I (P-value = 0.79, X2=0.47), BD-II(P-value = 0.79, X2=0.46); allele, BD-I [P-value = 0.58; odds ratio (OR) = 1.12, 95% confidence interval (CI): 0.74-1.69, X2=0.24], BD-II (P-value = 0.62; OR = 1.12, 95%CI: 0.69-1.83, X2=0.31)
|
No significant association was observed in BD.
No significant association was observed in BD.
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| BCL2 |
No significant differences were observed in the genotype frequencies or allele frequencies compared ......
No significant differences were observed in the genotype frequencies or allele frequencies compared with healthy subjects among BD-I, BD-II.
More...
|
Negative
|
Genetic factors reported by this study for SZ and/or MDD
