SNP Report

Basic Info

Name	rs2268026 dbSNP Ensembl
Location	chr3:52744331 - 52744331(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.332468
Functional Annotation	downstream_gene_variant; intron_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000487068); intron_variant(ENST00000233027, ENST00000383721, ENST00000461689, ENST00000493199, ENST00000535191); non_coding_transcript_variant(ENST00000493199)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013			P-value=0.0000001104, OR=1.145 for BIP, P-value=0.0000000341...... P-value=0.0000001104, OR=1.145 for BIP, P-value=0.00000003412, OR=1.099 for combined sample More...	In the combined analysis of these 819 SNPs, 15 exceeded geno...... In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.11. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NEK4	NIMA-related kinase 4	3p21.1	1(1/0/0)

SNPs in LD with rs2268026 (count: 0) View in gBrowse (chr3:52744331..52744331 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Major Depressive Disorder Working Group of the Psychiatric, G. C., 2013	P-value=0.007732, OR=1.063 for MDD, P-value=0.00000003412, OR=1.099 for combined sample	In the combined analysis of these 819 SNPs, 15 exceeded genome-wide significance and all were in a 248 kb interval of high LD on 3p21.11.	Positive