SNP Report

Basic Info

Name	rs41423247 dbSNP Ensembl
Location	chr5:143399010 - 143399010(1)
Variant Alleles	G/C
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.254593
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000502500, ENST00000502892, ENST00000508760, ENST00000510170, ENST00000514699); intron_variant(ENST00000231509, ENST00000343796, ENST00000394464, ENST00000394466, ENST00000415690, ENST00000424646, ENST00000503201, ENST00000504572)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Leszczynska-Rodziewicz A, 2013	C/G	P-value=0.2 P-value=0.2	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
Szczepankiewicz, A.,2011	C/G	For BD, X² test: allele, P-value > 0.05; the Fish...... For BD, X² test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.192 More...	No significant association was observed in BD. No significant association was observed in BD.	Negative
Leszczynska-Rodziewicz, A., 2012	C/G	genotypic P-value = 0.49 genotypic P-value = 0.49	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	5q31-q32	5(2/3/0)

SNPs in LD with rs41423247 (count: 0) View in gBrowse (chr5:143399010..143399010 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A.,2011	X² test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05	No significant association was observed.	Negative