SNP Report

Basic Info

Name	rs4076452 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG5:45790136 - 45790136(1)
Variant Alleles	C/G
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.133786
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000587305, ENST00000634540); non_coding_transcript_variant(ENST00000587305, ENST00000631500, ENST00000632599, ENST00000631500, ENST00000632599)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Leszczynska-Rodziewicz A, 2013	C/G	P-value=0.60 P-value=0.60	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
Szczepankiewicz, A., 2013	C/G	allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 95...... allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 95% CI=0.940-1.386 for affective disorder; allelic P-value=0.321, genotypic P-value=0.099, OR=1.123, 95% CI=0.892-1.372 for BD More...	For the CRHR1 gene, we observed an association of rs4076452 ...... For the CRHR1 gene, we observed an association of rs4076452 with mood disorders. This was not observed in the bipolar disorder. More...	Negative
Leszczynska-Rodziewicz, A., 2012	C/G	genotypic P-value = 0.23 genotypic P-value = 0.23	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CRHR1	corticotropin releasing hormone receptor 1	17q21.31	4(2/2/0)

SNPs in LD with rs4076452 (count: 1) View in gBrowse (chrCHR_HSCHR17_2_CTG5:45788256..45790136 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs12953076		intron_variant; non_coding_transcript_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A., 2013	allelic P-value=0.196, genotypic P-value=0.013, OR=1.142, 95% CI=0.940-1.386 for affective disorder; allelic P-value=0.177, genotypic P-value=0.02, OR=1.225, 95% CI=0.917-1.635 for MDD	We found that rs4076452 was significantly associated with an increased risk for MDD in our group.	Positive