Study Report

Reference	Schosser, A., 2010 PMID: 19255581
Citation	Schosser, A., D. Gaysina, et al. (2010). "Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies." Mol Psychiatry 15(8): 844-9.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	1469 MDD, 515 BD and 1376 ethnically matched controls
SNP/Region/Marker Size	8 SNPs
Predominant Ethnicity	Caucasian
Population	UK
Gender	446 men, 1023 women for 1469 MDD patients; 176 men, 339 women for 515 BD patients; 579 men, 797 women for controls
Age Group	adult : mean age = 47.39 (s.d. = 12.33) for MDD patients; mean age = 47.99 (s.d. = 11.40) for BD patients; mean age=41.70(s.d.=13.16) for controls.

Sample Diagnosis	DSM-IV and ICD 10
Sample Status	Only participants of white European parentage were included. Participants were excluded if they, or a firstdegree relative, ever fulfilled the criteria for mania, hypomania or SZ. Moreover, the participants were also excluded, if they experienced psychotic symptoms that were mood incongruent or present when there was no evidence of a mood disturbance.
Technique	Genotyping using the SNPlex Genotyping System (Applied Biosystems, Foster City, CA, USA).
Statistical Method	Computer program FINETTI was used to perform exact statistics. The UNPHASED program was applied to test for haplotypic association. The haploview 4.0 program was used to perform linkage disequilibrium analysis. The Power and Sample Size Calculations (PS) program was used to calculate the power. The problem of multiple testing was addressed by the false discovery rate (FDR) method.
Result Summary	We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD.