BDgene

Study Report

Basic Info
Reference
Citation Schosser, A., D. Gaysina, et al. (2010). "Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies." Mol Psychiatry 15(8): 844-9.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 1469 MDD, 515 BD and 1376 ethnically matched controls
SNP/Region/Marker Size 8 SNPs
Predominant Ethnicity Caucasian
Population UK
Gender 446 men, 1023 women for 1469 MDD patients; 176 men, 339 women for 515 BD patients; 579 men, 797 women for controls
Age Group adult : mean age = 47.39 (s.d. = 12.33) for MDD patients; mean age = 47.99 (s.d. = 11.40) for BD patients; mean age=41.70(s.d.=13.16) for controls.

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 8)

Haplotypes reported by this study for BD (count: 10)

Genes reported by this study for BD (count: 2)

Gene-gene interactions reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
MDD rs1000731 DISC1 TSNAX genotypic/allelic test P-value: 0.84/0.57 No significant genotypic or allelic association was observed. Negative
MDD rs2492367 DISC1 TSNAX genotypic/allelic test P-value: 0.31/0.97 No significant genotypic or allelic association was observed. Negative
MDD rs12133766 DISC1 genotypic/allelic test P-value: 0.69/0.60 No significant genotypic or allelic association was observed. Negative
MDD rs6675281 DISC1 TSNAX genotypic/allelic test P-value: 0.47/0.23 No significant genotypic or allelic association was observed. Negative
MDD rs3738401 DISC1 TSNAX genotypic/allelic test P-value: 0.77/0.59 No significant genotypic or allelic association was observed. Negative
MDD rs766288 TSNAX DISC1 genotypic/allelic test P-value: 0.27/0.15 No significant genotypic or allelic association was observed. Negative
MDD rs7546310 DISC1 DISC1-IT1 genotypic/allelic test P-value: 0.13/0.066 No significant genotypic or allelic association was observed. Negative
MDD rs821597 DISC1 TSNAX genotypic/allelic test P-value: 0.40/0.28 No significant genotypic or allelic association was observed. Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
MDD rs7546310 - rs821597 AT DISC1 Individual P-value = 0.003, global P-value = 0.034 showed an association with MDD. Individual haplotype analyses showed that this A-T haplotype was over-represented in MDD. Positive
MDD rs6675281 - rs12133766 - rs1000731 CGA DISC1 global P-value = 0.74 Negative
MDD rs766288 - rs2492367 AC TSNAX DISC1 global P-value = 0.54 Negative
MDD rs766288 - rs2492367 - rs6675281 ACC DISC1 Individual P-value = 0.04, global P-value = 0.24 Positive
MDD rs1000731 - rs7546310 AC DISC1 global P-value = 0.32 Negative
MDD rs1000731 - rs7546310 - rs821597 ACC DISC1 global P-value = 0.29 Negative
MDD rs12133766 - rs1000731 GA DISC1 global P-value = 0.81 Negative
MDD rs12133766 - rs1000731 - rs7546310 GAC DISC1 global P-value = 0.36 Negative
MDD rs2492367 - rs6675281 TC DISC1 global P-value = 0.77 Negative
MDD rs2492367 - rs6675281 - rs12133766 TCG DISC1 global P-value = 0.84 Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD DISC1 a haplotypic association was found for both BD and MDD. Positive
MDD TSNAX A haplotypic association was found for both BD and MDD Positive

Gene-gene interactions reported by this study for SZ/MDD
Disease Gene Group Markers Statistical Values Description Result Category
MDD rs766288 - rs2492367 global P-value = 0.54 Negative