SNP Report

Basic Info

Name	rs6850524 dbSNP Ensembl
Location	chr4:55515830 - 55515830(1)
Variant Alleles	C/G
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.445288
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000381322, ENST00000435527, ENST00000506923, ENST00000509151, ENST00000513033, ENST00000513440); non_coding_transcript_variant(ENST00000506923, ENST00000509151, ENST00000513033)
No. of Studies	3 (Positive: 2; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Kripke, D. F.,2009	C/G	TDT: In BP: OR=0.823, CHISQ=4.864, P-value = 0.0274, empiric...... TDT: In BP: OR=0.823, CHISQ=4.864, P-value = 0.0274, empirical P-value = 0.0322, corrected empirical P-value = 0.984 More...	Significant association was observed in the BP group. Significant association was observed in the BP group.	Positive
Shi, J., 2008 (d)	C/G	Allelic TDT P-value = 0.012 in bipolar disorder (Sample II) Allelic TDT P-value = 0.012 in bipolar disorder (Sample II)	In Sample II, which is larger, three SNPs (rs534654, rs68505...... In Sample II, which is larger, three SNPs (rs534654, rs6850524, and rs4340844) at the CLOCK gene region showed suggestive evidence for transmission disequilibrium. However, none of these associations reached gene-wide or experiment-wide significance after correction for multiple-testing. More...	Positive
Soria, V.,2010		X²-tests: allele P-value > 0.05, genotype P-value...... X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CLOCK	clock circadian regulator	4q12	12(5/7/0)

SNPs in LD with rs6850524 (count: 0) View in gBrowse (chr4:55515830..55515830 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Soria, V.,2010	X²-tests:allele P-value = 0.056, Model Log-additive, genotype P-value = 0.015, OR(95%CI)=1.30 (1.05-1.61)	Significant association was found.	Positive