SNP Report

Basic Info

Name	rs9470080 dbSNP Ensembl
Location	chr6:35678658 - 35678658(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	T
Minor Allele Frequence	0.363419
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000357266, ENST00000536438, ENST00000539068, ENST00000542713)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Szczepankiewicz A., 2014	C/T		P-value=0.471 P-value=0.471	Our main finding is no association with bipolar disorder. Our main finding is no association with bipolar disorder.	Negative
Ceulemans, S.,2011	T/C		Single SNP analyses: Permuted P-value = 0.6635, Odds Ratio=1...... Single SNP analyses: Permuted P-value = 0.6635, Odds Ratio=1.054 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
FKBP5	FK506 binding protein 5	6p21.31	5(1/4/0)

SNPs in LD with rs9470080 (count: 10) View in gBrowse (chr6:35599983..35707068 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs9368881	intron_variant; upstream_gene_variant	0.95[CEU]; 0.976[TSI]
rs9380526	intron_variant; upstream_gene_variant	0.95[CEU]; 0.976[TSI]
rs943297	intron_variant	0.903[TSI]
rs3798347	intron_variant	0.809[CEU]
rs9462104	intron_variant	0.809[CEU]; 0.857[TSI]
rs6902321	intron_variant	0.809[CEU]
rs7751598	intron_variant	0.809[CEU]; 0.905[TSI]
rs2395634	intron_variant	0.809[CEU]; 0.905[TSI]
rs4713904	intron_variant	0.902[CEU]; 0.952[TSI]
rs9368878	intron_variant	0.809[CEU]; 0.876[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz A., 2014	P-value=0.007	Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.	Positive