SNP Report

Basic Info

Name	rs9296158 dbSNP Ensembl
Location	chr6:35599305 - 35599305(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.359425
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000357266, ENST00000536438, ENST00000539068, ENST00000542713)
No. of Studies	3 (Positive: 1; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Szczepankiewicz A., 2014	A/G	P-value=0.837 P-value=0.837	Our main finding is no association with bipolar disorder. Our main finding is no association with bipolar disorder.	Negative
Ceulemans, S.,2011	A/G	Single SNP analyses: Permuted P-value = 0.9192, Odds Ratio=1...... Single SNP analyses: Permuted P-value = 0.9192, Odds Ratio=1.014 More...	No significant association was observed. No significant association was observed.	Negative
Willour, V. L.,2009	G/A	FBAT: Additive model: major allele P-value = 0.083, minor al...... FBAT: Additive model: major allele P-value = 0.083, minor allele P-value = 0.083; Dominant model: major allele P-value = 0.020, minor allele P-value = 0.487; Genotypic association: TDT P-value = 0.05 More...	It showed a significant overtransmission under the dominant ...... It showed a significant overtransmission under the dominant model. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
FKBP5	FK506 binding protein 5	6p21.31	5(1/4/0)

SNPs in LD with rs9296158 (count: 4) View in gBrowse (chr6:35599305..35637423 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs2395634	intron_variant	0.85[CEU]
rs3798347	intron_variant	0.86[CEU]
rs7751598	intron_variant	0.85[CEU]
rs9368878	intron_variant	0.85[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz A., 2014	P-value=0.03	Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.	Positive