BDgene

Study Report

Basic Info
Reference
Citation Fukuo, Y., T. Kishi, et al. (2010). "Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis." Neurosci Res 67(3): 250-255.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 1007 BP patients, 447 MDD patients and 1753 controls
SNP/Region/Marker Size 5 SNPs
Predominant Ethnicity Mongloid
Population Japanese
Gender 493 males and 514 females in BD patients,211 males and 236 females in MDD patients and 843 males and 910 females in controls
Age Group Adults : Mean age(SD)(year):47.9(14.2) in BD patients,48.7(16.1) in MDD patients and 44.2(15.0) in controls

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 5)

Haplotypes reported by this study for BD (count: 10)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
MDD rs9659997 HTR6 Association analysis:genotype P-value = 0.65, allele P-value = 0.966 No significant association was observed. Negative
MDD rs4912138 HTR6 Association analysis:genotype P-value = 0.894, allele P-value = 0.938 No significant association was observed. Negative
MDD rs6693503 HTR6 NBL1 MINOS1-NBL1 Association analysis:genotype P-value = 0.977, allele P-value = 0.904 No significant association was observed. Negative
MDD rs1805054 HTR6 Association analysis:genotype P-value = 0.917, allele P-value = 0.963;meta analysis:fixed model: pooled OR= 0.943, 95%CI = 0.820-1.08, P(Z) = 0.406 No significant association was observed. Negative
MDD rs3790757 HTR6 Association analysis:genotype P-value = 0.479, allele P-value = 0.366 No significant association was observed. Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
MDD rs1805054 - rs4912138 - rs3790757 HTR6 Haplotype-wise analysis:global P-value = 0.571 No significant association was found . Negative
MDD rs1805054 - rs4912138 HTR6 Haplotype-wise analysis:global P-value = 0.947 No significant association was found . Negative
MDD rs6693503 - rs1805054 - rs4912138 - rs3790757 - rs9659997 HTR6 Haplotype-wise analysis:global P-value = 0.6 No significant association was found . Negative
MDD rs6693503 - rs1805054 - rs4912138 - rs3790757 HTR6 Haplotype-wise analysis:global P-value = 0.256 No significant association was found . Negative
MDD rs6693503 - rs1805054 - rs4912138 HTR6 Haplotype-wise analysis:global P-value = 0.221 No significant association was found . Negative
MDD rs6693503 - rs1805054 HTR6 Haplotype-wise analysis:global P-value = 0.888 No significant association was found . Negative
MDD rs4912138 - rs3790757 - rs9659997 HTR6 Haplotype-wise analysis:global P-value = 0.647 No significant association was found . Negative
MDD rs4912138 - rs3790757 HTR6 Haplotype-wise analysis:global P-value = 0.435 No significant association was found . Negative
MDD rs3790757 - rs9659997 HTR6 Haplotype-wise analysis:global P-value = 0.641 No significant association was found . Negative
MDD rs1805054 - rs4912138 - rs3790757 - rs9659997 HTR6 Haplotype-wise analysis:global P-value = 0.799 No significant association was found . Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD HTR6 In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. Negative