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Study Report
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Reference | Fukuo, Y.,2010 PMID: 20394784 |
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Citation | Fukuo, Y., T. Kishi, et al. (2010). "Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis." Neurosci Res 67(3): 250-255. |
Disease Type | Bipolar Disorder & Major Depressive Disorder |
Study Design | case-control |
Study Type | Candidate-gene association study |
Sample Size | 1007 BP patients, 447 MDD patients and 1753 controls |
SNP/Region/Marker Size | 5 SNPs |
Predominant Ethnicity | Mongloid |
Population | Japanese |
Gender | 493 males and 514 females in BD patients,211 males and 236 females in MDD patients and 843 males and 910 females in controls |
Age Group | Adults : Mean age(SD)(year):47.9(14.2) in BD patients,48.7(16.1) in MDD patients and 44.2(15.0) in controls |
Sample Diagnosis | DSM |
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Sample Status | The subjects in the association analysis were 1007 BP patients (709 patients with bipolar I disorder and 298 patients with bipolar II disorder), 447 MDD patients, and 1753 healthy controls. All subjects were unrelated to each other, ethnically Japanese, and lived in the central area of Japan. 238 patients were diagnosed according to DSM-IV criteria with the consensus of at least two experienced psychiatrists on the basis of unstructured interviews and a review of medical records, although 209 of the patients underwent the Mini-International Neuropsychiatric Interview (MINI). Of the 450 MDD patients, 261 were treated with fluvoxamine, sertraline or paroxetine. 1576 controls were also diagnosed according to DSM-IV criteria with the consensus of at least two experienced psychiatrists on the basis of unstructured interviews, although 46 or 131 controls underwentthe MINI or Structured Clinical Interview forDSM-IVdisorders (SCID-1), respectively.Nonehad severe medical complications such as liver cirrhosis, renal failure, heart failure or other Axis-I disorders according to DSM-IV. Controls included hospital staff and medical students. |
Technique | genotyping |
Statistical Method | Among the clinical characteristics of patients in this pharmacogenetic study, individual t-test and chi-square tests(Fisher's exact test when appropriate) were used to compare means and categorical proportions, respectively. |
Result Summary | RESULTS: The control subjects and the two groups of patients were similar with respect to the genotype and allele distribution belonging to the two polymorphisms in the serotonin transporter gene for. An interaction between status (control, unipolar- or bipolar patient) and VNTR genotype regarding the number of platelet serotonin transporters was observed; unipolar patients with the genotype 12/10 had more platelet serotonin transporters than bipolar patients and controls with this genotype. No association related to the polymorphism was found in the promoter region of the serotonin transporter gene. CONCLUSION: An association was observed between the polymorphism in intron 2 of the serotonin transporter gene and the number of platelet serotonin transporters. Unipolar patients with a particular genotype had more platelet serotonin transporters than the corresponding controls and bipolar patients. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs1805054 | HTR6 | C>T | Association analysis: genotype P-value = 0.271, allele P-value = 0.332; meta-analysis: random model: pooled OR= 0.902, 95%CI = 0.531-1.53, P(Z) = 0.702 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs3790757 | HTR6 | C>T | Association analysis: genotype P-value = 0.232, allele P-value = 0.935 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs9659997 | HTR6 | C>T | Association analysis: genotype P-value = 0.52, allele P-value = 0.35 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs4912138 | HTR6 | A>G | Association analysis: genotype P-value = 0.136, allele P-value = 0.0709 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs6693503 | HTR6 NBL1 MINOS1-NBL1 | A>G | Association analysis: genotype P-value = 0.893, allele P-value = 0.751 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
---|---|---|---|---|---|
rs4912138 - rs3790757 | HTR6 | Haplotype-wise analysis:global P-value = 0.13 | No significant association was found . No significant association was found . | Negative | |
rs4912138 - rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.252 | No significant association was found . No significant association was found . | Negative | |
rs1805054 - rs4912138 - rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.334 | No significant association was found . No significant association was found . | Negative | |
rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.687 | No significant association was found . No significant association was found . | Negative | |
rs6693503 - rs1805054 - rs4912138 - rs3790757 | HTR6 | Haplotype-wise analysis:global P-value = 0.318 | No significant association was found . No significant association was found . | Negative | |
rs6693503 - rs1805054 - rs4912138 - rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.515 | No significant association was found . No significant association was found . | Negative | |
rs6693503 - rs1805054 | HTR6 | Haplotype-wise analysis:global P-value = 0.426 | No significant association was found . No significant association was found . | Negative | |
rs6693503 - rs1805054 - rs4912138 | HTR6 | Haplotype-wise analysis:global P-value = 0.297 | No significant association was found . No significant association was found . | Negative | |
rs1805054 - rs4912138 - rs3790757 | HTR6 | Haplotype-wise analysis:global P-value = 0.23 | No significant association was found . No significant association was found . | Negative | |
rs1805054 - rs4912138 | HTR6 | Haplotype-wise analysis:global P-value = 0.189 | No significant association was found . No significant association was found . | Negative |
Gene | Statistical Values/Author Comments | Result Category |
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HTR6 | In conclusion, we found no association involving polymorphism and mood disorder in the Japanese popu...... In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. More... | Negative |
Disease | SNP | Related Gene(s) | Statistical Values | Description | Result Category |
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MDD | rs9659997 | HTR6 | Association analysis:genotype P-value = 0.65, allele P-value = 0.966 | No significant association was observed. | Negative |
MDD | rs4912138 | HTR6 | Association analysis:genotype P-value = 0.894, allele P-value = 0.938 | No significant association was observed. | Negative |
MDD | rs6693503 | HTR6 NBL1 MINOS1-NBL1 | Association analysis:genotype P-value = 0.977, allele P-value = 0.904 | No significant association was observed. | Negative |
MDD | rs1805054 | HTR6 | Association analysis:genotype P-value = 0.917, allele P-value = 0.963;meta analysis:fixed model: pooled OR= 0.943, 95%CI = 0.820-1.08, P(Z) = 0.406 | No significant association was observed. | Negative |
MDD | rs3790757 | HTR6 | Association analysis:genotype P-value = 0.479, allele P-value = 0.366 | No significant association was observed. | Negative |
Disease | Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Description | Result Category |
---|---|---|---|---|---|---|
MDD | rs1805054 - rs4912138 - rs3790757 | HTR6 | Haplotype-wise analysis:global P-value = 0.571 | No significant association was found . | Negative | |
MDD | rs1805054 - rs4912138 | HTR6 | Haplotype-wise analysis:global P-value = 0.947 | No significant association was found . | Negative | |
MDD | rs6693503 - rs1805054 - rs4912138 - rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.6 | No significant association was found . | Negative | |
MDD | rs6693503 - rs1805054 - rs4912138 - rs3790757 | HTR6 | Haplotype-wise analysis:global P-value = 0.256 | No significant association was found . | Negative | |
MDD | rs6693503 - rs1805054 - rs4912138 | HTR6 | Haplotype-wise analysis:global P-value = 0.221 | No significant association was found . | Negative | |
MDD | rs6693503 - rs1805054 | HTR6 | Haplotype-wise analysis:global P-value = 0.888 | No significant association was found . | Negative | |
MDD | rs4912138 - rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.647 | No significant association was found . | Negative | |
MDD | rs4912138 - rs3790757 | HTR6 | Haplotype-wise analysis:global P-value = 0.435 | No significant association was found . | Negative | |
MDD | rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.641 | No significant association was found . | Negative | |
MDD | rs1805054 - rs4912138 - rs3790757 - rs9659997 | HTR6 | Haplotype-wise analysis:global P-value = 0.799 | No significant association was found . | Negative |
Disease | Gene | Description | Result Category |
---|---|---|---|
MDD | HTR6 | In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016