SNP Report

Basic Info

Name	rs1611115 dbSNP Ensembl
Location	chr9:133635393 - 133635393(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.21266
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000263611, ENST00000393056, ENST00000564021)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ates, O.,2013	C/T		Genotypic P-value = 0.0012;allelic P-value = 0.034,OR(95%CI)...... Genotypic P-value = 0.0012;allelic P-value = 0.034,OR(95%CI) = 2.22 (0.88-6.08) More...	The results showed statistically significant associations fo...... The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism and bipolar disease. More...	Positive
Hess, C.,2009	C/T		DBH genotype and affective disorders: total(X² = ...... DBH genotype and affective disorders: total(X² = 0.55, P-value = 0.758), Unipolar(X² = 2.05, P-value = 0.359), Bipolar(X² = 0.90, P-value = 0.638); DBH genotype and personality disorders: total(X² = 3.03, P-value = 0.220), Cluster A(X² = 1.09, P-value = 0.581), Cluster B(X² = 0.25, P-value = 0.883), Cluster C(X² = 5.09, P-value = 0.079), Mixed(X² = 10.35, P-value = 0.006); DBH genotype and adult ADHD: total(X² = 5.33, P-value = 0.07) DBH genotype and anxiety and depression related personality traits: 1.Patients with personality disorder: NEO-PI-R neuroticism(CC vs. CT vs. TT F^{2, 631 ^{= 3.12, P-value = 0.045; C+ vs.C- F^{1, 632^{= 5.70, P-value = 0.017); TPQ novelty seeking(CC vs. CT vs. TT F^{2, 631 ^{= 3.13, P-value = 0.045; C+ vs.C- F^{1, 632^{= 4.88, P = 0.027).2.Combined sample(personality disorder and ADHD): NEO-PI-R neuroticism(CC vs. CT vs. TT F^{2, 929 ^{= 4.83, P-value = 0.008; C+ vs.C- F^{1, 930^{=9.57, P-value = 0.002)}}}}}}}}}}}} More...	No differences in DBH C-1021T genotype distribution were obs...... No differences in DBH C-1021T genotype distribution were observed between patients with affective disorders and healthy control subjects. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	9q34	3(1/2/0)

SNPs in LD with rs1611115 (count: 1) View in gBrowse (chr9:133635393..133637206 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs2519143		intron_variant; upstream_gene_variant	0.935[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Hess, C.,2009	DBH genotype and affective disorders:total(X² = 0.55, P-value = 0.758), Unipolar(X² = 2.05, P-value = 0.359), Bipolar(X² = 0.90, P-value = 0.638)	No differences in DBH C-1021T genotype distribution were observed	Negative