SNP Report

Basic Info

Name	rs734312 dbSNP Ensembl
Location	chr4:6301627 - 6301627(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.469249
Functional Annotation	downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant. Polyphen Annotation: benign(ENST00000226760, ENST00000503569) SIFT Annotation: deleterious(ENST00000226760, ENST00000503569)
Consequence to Transcript	downstream_gene_variant(ENST00000506362, ENST00000513395); missense_variant(ENST00000226760, ENST00000503569); non_coding_transcript_exon_variant(ENST00000507765); non_coding_transcript_variant(ENST00000507765)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Tang, X. W., 2014	A/G		Patients with BD (R vs. H: OR=0.91, 95% CI=0.79-1.05, P-valu...... Patients with BD (R vs. H: OR=0.91, 95% CI=0.79-1.05, P-value=0.21; HR+RR vs. HH: OR=0.97, 95% CI=0.78-1.20, P-value=0.79; RR vs. HH+HR: OR=0.81, 95% CI=0.62-1.05, P-value=0.11; RR vs. HH: OR=0.82, 95% CI=0.60-1.13, P-value=0.23; HR vs. HH: OR=1.02, 95% CI=0.82-1.28, P-value=0.85). More...	No significant associations were observed. No significant associations were observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
WFS1	Wolfram syndrome 1 (wolframin)	4p16.1	7(1/6/0)

SNPs in LD with rs734312 (count: 0) View in gBrowse (chr4:6301627..6301627 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Tang, X. W., 2014	patients with MDD (R vs. H: OR=0.95, 95% CI=0.70-1.28, P-value=0.73; HR+RR vs. HH: OR= 1.01, 95% CI=0.61-1.67, P-value=0.97; RR vs. HH+HR: OR=0.79, 95% CI=0.59-1.07, P-value=0.13; RR vs. HH: OR=0.84, 95% CI=0.59-1.20, P-value=0.34; HR vs. HH: OR=1.07, 95% CI=0.64-1.78, P-value=0.60).	No significant associations were observed.	Negative