SNP Report

Basic Info

Name	rs11178997 dbSNP Ensembl
Location	chr12:71938373 - 71938373(1)
Variant Alleles	T/A
Ancestral Allele	T
Minor Allele	A
Minor Allele Frequence	0.151158
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000333850, ENST00000546576)
No. of Studies	5 (Positive: 1; Negative: 4; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Grigoroiu-Serbanescu, M.,2008	T/A		Cochrane-Armitage trend test P value=0.63 Cochrane-Armitage trend test P value=0.63		Negative
Lopez, V. A., 2007	A/T		FBAT P-value = 0.511, Z=0.656 in the NIMH 'Wave 3' Sample FBAT P-value = 0.511, Z=0.656 in the NIMH 'Wave 3' Sample	did not show significant association with BPAD or with SA in...... did not show significant association with BPAD or with SA in the individual marker tests More...	Negative
Van Den Bogaert, A., 2006 (a)	A/T		genotypic P-value = 0.18, allelic P-value = 0.16 genotypic P-value = 0.18, allelic P-value = 0.16		Negative
Lin, Y. M., 2007	T/A		chi-square P-value = 0.72 chi-square P-value = 0.72	this SNP was not associated with the disease this SNP was not associated with the disease	Negative
Cichon, S., 2008	T/A	A	Cochrane-Armitage trend test P-value = 0.0047 , OR (95% CI)=...... Cochrane-Armitage trend test P-value = 0.0047 , OR (95% CI)=1.5 (1.1-1.9) in the German BPAD sample. Cochrane-Armitage trend test P-value = 0.0668 , OR (95% CI)=1.6 (0.96-2.6) in the Russian BPAD sample. Cochrane-Armitage trend test P-value = 0.00073 , OR (95% CI)=1.5 (1.2-1.9) in Combined German/Russian sample. More...	In the German sample, the minor alleles of SNPs rs11178997, ...... In the German sample, the minor alleles of SNPs rs11178997, rs11178998 and rs7954758 were significantly over-represented in BPAD patients when compared with controls. In the Russian replication sample, the three SNPs in the 5' region showed a non-significant trend. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TPH2	tryptophan hydroxylase 2	12q15	13(10/3/0)

SNPs in LD with rs11178997 (count: 0) View in gBrowse (chr12:71938373..71938373 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Van Den Bogaert, A., 2006 (a)	genotypic P-value = 0.001, allelic P-value = 0.001	In the sample of patients with UP disorder and controls, significant association was observed for the A allele of rs11178997.	Positive