BDgene

SNP Report

Basic Info
Name rs11178997 dbSNP Ensembl
Location chr12:71938373 - 71938373(1)
Variant Alleles T/A
Ancestral Allele T
Minor Allele A
Minor Allele Frequence 0.151158
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000333850, ENST00000546576)
No. of Studies 5 (Positive: 1; Negative: 4; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Grigoroiu-Serbanescu, M.,2008 T/A Cochrane-Armitage trend test P value=0.63 Cochrane-Armitage trend test P value=0.63 Negative
Lopez, V. A., 2007 A/T FBAT P-value = 0.511, Z=0.656 in the NIMH 'Wave 3' Sample FBAT P-value = 0.511, Z=0.656 in the NIMH 'Wave 3' Sample did not show significant association with BPAD or with SA in...... did not show significant association with BPAD or with SA in the individual marker tests More... Negative
Van Den Bogaert, A., 2006 (a) A/T genotypic P-value = 0.18, allelic P-value = 0.16 genotypic P-value = 0.18, allelic P-value = 0.16 Negative
Lin, Y. M., 2007 T/A chi-square P-value = 0.72 chi-square P-value = 0.72 this SNP was not associated with the disease this SNP was not associated with the disease Negative
Cichon, S., 2008 T/A A Cochrane-Armitage trend test P-value = 0.0047 , OR (95% CI)=...... Cochrane-Armitage trend test P-value = 0.0047 , OR (95% CI)=1.5 (1.1-1.9) in the German BPAD sample. Cochrane-Armitage trend test P-value = 0.0668 , OR (95% CI)=1.6 (0.96-2.6) in the Russian BPAD sample. Cochrane-Armitage trend test P-value = 0.00073 , OR (95% CI)=1.5 (1.2-1.9) in Combined German/Russian sample. More... In the German sample, the minor alleles of SNPs rs11178997, ...... In the German sample, the minor alleles of SNPs rs11178997, rs11178998 and rs7954758 were significantly over-represented in BPAD patients when compared with controls. In the Russian replication sample, the three SNPs in the 5' region showed a non-significant trend. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0)

SNPs in LD with rs11178997 (count: 0) View in gBrowse (chr12:71938373..71938373 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Van Den Bogaert, A., 2006 (a) genotypic P-value = 0.001, allelic P-value = 0.001 In the sample of patients with UP disorder and controls, significant association was observed for the A allele of rs11178997. Positive