SNP Report

Basic Info

Name	rs17452383 dbSNP Ensembl
Location	chr11:13388824 - 13388824(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.0828674
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000278174, ENST00000527102, ENST00000528120, ENST00000530907); downstream_gene_variant(ENST00000389707, ENST00000401424, ENST00000403290, ENST00000403482, ENST00000403510, ENST00000472842, ENST00000524392); NMD_transcript_variant(ENST00000527102)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Soria, V.,2010			X²-tests: allele P-value > 0.05, genotype P-value...... X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	11p15	7(5/2/0)
BTBD10	BTB (POZ) domain containing 10	11p15.2	Mapped by Literature SNP

SNPs in LD with rs17452383 (count: 2) View in gBrowse (chr11:13388824..13459549 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs3761862		downstream_gene_variant; intron_variant; NMD_transcript_variant	1.0[CEU]
rs4356206		intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Soria, V.,2010	X²-tests:allele P-value = 0.938, Model Recessive, genotype P-value = 0.035, OR(95%CI)=3.00 (1.03-8.77)	Significant association was found.	Positive