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Basic Info

Reference	Grigoroiu-Serbanescu, M.,2009 PMID: 19330776
Citation	Grigoroiu-Serbanescu, M., S. Herms, et al. (2009). Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples. Am J Med Genet B Neuropsychiatr Genet 150B(7): 1017-1021.
Disease Type	Bipolar I Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	BPI:N=1445 patients,N=2006 controls in total(N=639 patients,N=1095 controls in Germany;N=366 patients,N=508 controls in Poland;N=198 patients,N=170 controls in Romania and N=248 patients,N=229 controls in Russia);Mdd-UP:N=640 patients,N=1095 controls in Germany;Total sample major mood disorders:N=1445 patients,N=2006 controls
SNP/Region/Marker Size	1 SNPs
Predominant Ethnicity	Caucasian
Population	European(German,Polish,Romanian and Russian)
Gender	females proportion:BPI:55.5% in patients,55.48% in controls in total(53% in patients,51.5% in controls in Germany;57.65% in patients,62.6% in controls in Poland;57.9% in patients,56.8% in controls in Romania and 56% in patients,54% in controls in Russia);Mdd-UP:63.59% in patients,51.5% in controls in Germany;Total sample major mood disorders:58.12% in patients,55.48% in controls
Age Group	Adults : BPI:mean AO=26.9(SD=10.6),mean AI=42.7(SD=12.5) in patients,mean AI=39.74(SD=11.22) in controls in total(mean AO=27.0(SD=10.6),mean AI=43.5(SD=13.1) in patients,mean AI=48.4(SD=15.5) in controls in Germany;mean AO=26.8, SD=10.22; mean AI=45.04, SD=13.33 in patients,mean AI=39.83, SD=11.33 in controls in Romania and mean AO=26.8, SD=11.3; mean AI=40.95, SD=12.44 in patients,mean AI=38.1, SD=15.4 in controls in Russia);Mdd-UP:mean AO=36.0, SD=13.1; mean AI=47.0, SD=13.5 in patients,mean AI=48.4, SD=15.5 in controls in Germany;Total sample major mood disorders:mean AO=26.9, SD=10.6; mean AI=42.7, SD=12.5 in patients,mean AI=39.74, SD=11.22 in controls(AO:age OF onset,AI:age at interview)

Detail Info

Sample Diagnosis	DSM
Sample Status	All patients were recruited from consecutive hospital admissions.After giving written informed consent all patients were directly interviewed with the SCID-I Patient Version.Information provided by medical records and interviews of family members were also used in a best estimate procedure of diagnoses based on DSM-IV-Rcriteria. The gender breakdown, the AO, and the AI were similar in all national patient samples. The control samples were population based, drawn from the same population as the patients. Only the Romanian control sample was screened for major psychiatric disorders. The ethnicity of the patients and controls was determined by genealogical investigation to the grandparental generation.
Technique	genotyping
Statistical Method	Cochrane-Armitage Trend Test for allelic association and incorporates the HWE,the genotypic association was determined through a likelihood ratio test based on an Expectation-Maximization algorithm.
Result Summary	We found no allelic or genotypic association between rs2230912 and BPI or Mdd-UP both in the national samples and in the combined European patient sample. Additional studies are needed to clarify the potential involvement of P2RX7 and of SNP rs2230912 in the etiology of major affective disorders.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2230912	P2RX7	A/G		1.Allelic Association Analysis and Genotype Frequencies of SNP rs2230912 (P2 RX7) in Patients and Controls in Four European Samples and in Combined Samples: Allele: P-value = 0.914(Armitage trend test), Corrected global P-value = 0.920 and Genotype: P-value = 0.678(2 df)in German BPI sample vs. German control sample; P-value = 0.125(Armitage trend test), Corrected global P-value = 0.125 and Genotype: P-value = 0.160(2 df)in Polish BPI vs. Polish control sample; P-value = 0.089(Armitage trend test), Corrected global P-value = 0.121 and Genotype: P-value = 0.304(2 df)in Romanian BPI vs. Romanian control sample; P-value = 0.735(Armitage trend test), Corrected global P-value = 0.73 and Genotype: P-value = 0.244(2 df)in Russian BPI vs. Russian control sample; P-value = 0.498(Armitage trend test), Corrected global P-value = 0.518 and Genotype: P-value = 0.460(2 df)in Combined BPI sample vs. combined control sample; P-value = 0.967(Armitage trend test), Corrected global P-value = 0.976 and Genotype: P-value = 0.999(2 df)in Combined major mood disorders sample vs.combined control sample. 2.Comparison of SNP rs2230912 Genotype Frequency in Bonn Samples With rs2230912 Genotype Frequency in Previously Published Samples [Barden et al., 2006; Lucae et al., 2006; McQuillin et al., 2008]: (1)X²=2.28, df=2, P-value = 0.319 and Armitage trend=2.28, P-value = 0.13 in BPI sample Bonn (n=1, 445) vs.BPI sample; Barden et al.(n=213)&McQuillin et al.(n=587); (2)X²=2.64, df=2, P-value = 0.266 and Armitage trend=2.38, P-value = 0.12 in Mood disorder sample Bonn (n=2, 085) vs. mood disorder sample; McQuillin et al.(n=578)&Barden et al.(n=213)&Lucae et al.(n=999); (3)X²=0.74, df=2, P-value = 0.69 and Armitage trend=0.47, P-value = 0.49 in Control sample Bonn (n=2, 006) vs.control sample; Barden et al.(212)&McQuillin et al.(n=546); (4)X²=3.20, df=2, P-value = 0.20 and Armitage trend=2.29, P-value = 0.13 in Control sample Bonn (n=2, 006) vs.control sample; Barden et al.(212)&McQuillin et al.(n=546)tLucae et al.(n=1, 029)	Both allelic and genotypic analyses failed to show an associ...... Both allelic and genotypic analyses failed to show an association between rs2230912 (P2RX7) and BPI.And we observed no significant differences between our samples and previously published samples indicating that population differences are unlikely to be the cause of the discrepant results. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
P2RX7	We found no allelic or genotypic association between rs2230912 and BPI or Mdd-UP both in the nationa...... We found no allelic or genotypic association between rs2230912 and BPI or Mdd-UP both in the national samples and in the combined European patient sample. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
MDD	rs2230912	P2RX7	Allelic Association Analysis and Genotype Frequencies of SNP rs2230912 (P2 RX7):P-value = 0.834(Armitage trend test), Corrected global P-value = 0.840 and Genotype:P-value = 0.772(2 df)in German Mdd-UP vs. German control sample	we observed no significant differences between German Mdd-UP samples and German control.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	P2RX7	we observed no significant differences between German Mdd-UP samples and German control.	Negative