BDgene

SNP Report

Basic Info
Name rs258813 dbSNP Ensembl
Location chr5:143295125 - 143295125(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele A
Minor Allele Frequence 0.23123
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000231509, ENST00000343796, ENST00000394464, ENST00000394466, ENST00000415690, ENST00000424646, ENST00000503201, ENST00000504572)
No. of Studies 3 (Positive: 0; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Szczepankiewicz, A.,2011 A/G For BD, X2 test: allele, P-value > 0.05; the Fish...... For BD, X2 test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.148 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Leszczynska-Rodziewicz A, 2013 A/G P-value=0.17 P-value=0.17 Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More... Negative
Leszczynska-Rodziewicz, A., 2012 A/G genotypic P-value = 0.61 genotypic P-value = 0.61 There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0)

SNPs in LD with rs258813 (count: 12) View in gBrowse (chr5:143242611..143381962 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 12)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Szczepankiewicz, A.,2011 X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 No significant association was observed. Negative