SNP Report

Basic Info

Name	rs1653625 dbSNP Ensembl
Location	chr12:121185082 - 121185082(1)
Variant Alleles	C/A
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.332867
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000261826, ENST00000328963); downstream_gene_variant(ENST00000535250, ENST00000535600, ENST00000537312, ENST00000538011, ENST00000539606, ENST00000539695, ENST00000541022, ENST00000541564, ENST00000541716); NMD_transcript_variant(ENST00000261826)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Halmai Z, 2013	A/C		no P-value no P-value	The case-control analyses did not show any significant diffe...... The case-control analyses did not show any significant difference in the genotype distributions of the two investigated P2RX7 polymorphisms (i.e.,rs2230912 and rs1653625) between the MDD or the BPD and the control groups. More...	Negative
Barden, N., 2006	C/G		Allelic P-value = 0.018, OR (CI 95%)=1.43 (1.07-1.92), genot...... Allelic P-value = 0.018, OR (CI 95%)=1.43 (1.07-1.92), genotypic P-value = 0.008, OR (CI 95%)=1.7 (1.16-2.51) under a dominant model More...	It gave significant allelic and/or genotypic association und...... It gave significant allelic and/or genotypic association under additive, dominant and recessive models. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
P2RX7	purinergic receptor P2X, ligand gated ion channel, 7	12q24	9(2/7/0)

SNPs in LD with rs1653625 (count: 0) View in gBrowse (chr12:121185082..121185082 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Halmai Z, 2013	P-value>0.05	The case-control analyses did not show any significant difference in the genotype distributions of the two investigated P2RX7 polymorphisms (i.e.,rs2230912 and rs1653625) between the MDD or the BPD and the control groups.	Negative