SNP Report

Basic Info

Name	rs10748185 dbSNP Ensembl
Location	chr12:71942075 - 71942075(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.377596
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000333850, ENST00000546576); non_coding_transcript_variant(ENST00000546576)
No. of Studies	3 (Positive: 2; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Result Category
Grigoroiu-Serbanescu, M.,2008	A/G		Cochrane-Armitage trend test P value=0.637 Cochrane-Armitage trend test P value=0.637	Negative
Van Den Bogaert, A., 2006 (a)	A/G		genotypic P-value = 0.049, allelic P-value = 0.05 genotypic P-value = 0.049, allelic P-value = 0.05	Positive
Cichon, S., 2008	A/G	G	Cochrane-Armitage trend test P-value = 0.4 in the German BPA...... Cochrane-Armitage trend test P-value = 0.4 in the German BPAD sample. Cochrane-Armitage trend test P-value > .0.5 in the Russian BPAD sample. Cochrane-Armitage trend test P-value = 0.33 in Combined German/Russian sample. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TPH2	tryptophan hydroxylase 2	12q15	13(10/3/0)

SNPs in LD with rs10748185 (count: 1) View in gBrowse (chr12:71942075..71942208 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs10748186		intron_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Van Den Bogaert, A., 2006 (a)	genotypic P-value = 0.48, allelic P-value = 0.48		Negative