SNP Report

Basic Info

Name	rs173365 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG5:45835327 - 45835327(1)
Variant Alleles	G/A
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.348043
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000293493, ENST00000314537, ENST00000339069, ENST00000347197, ENST00000352855, ENST00000398285, ENST00000577353, ENST00000580955, ENST00000582766, ENST00000583888, ENST00000619154, ENST00000634540, ENST00000634876); NMD_transcript_variant(ENST00000347197, ENST00000580955, ENST00000583888); non_coding_transcript_variant(ENST00000582766, ENST00000634876, ENST00000611599, ENST00000613260, ENST00000614143, ENST00000615345, ENST00000617446, ENST00000618382, ENST00000616225, ENST00000616274, ENST00000616748, ENST00000617905, ENST00000618144, ENST00000621969, ENST00000631395, ENST00000632383, ENST00000632552, ENST00000633723, ENST00000634181, ENST00000631395, ENST00000632383, ENST00000632552, ENST00000634181)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Leszczynska-Rodziewicz, A., 2012	A/G	genotypic P-value = 0.88 genotypic P-value = 0.88	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative
Leszczynska-Rodziewicz A, 2013	A/G	P-value=0.60 P-value=0.60	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
Szczepankiewicz, A., 2013	A/G	allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 95...... allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 95% CI=0.877-1.180 for affective disorder; allelic P-value=0.888, genotypic P-value=0.972, OR=0.984, 95% CI=0.835-1.161 for BD More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MAPT-AS1	MAPT antisense RNA 1	17q21.31	Mapped by Literature SNP
CRHR1	corticotropin releasing hormone receptor 1	17q21.31	4(2/2/0)

SNPs in LD with rs173365 (count: 1) View in gBrowse (chrCHR_HSCHR17_2_CTG5:45835327..45844708 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs17689966		downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.96[CEU]; 0.977[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A., 2013	allelic P-value=0.845, genotypic P-value=0.834, OR=1.018, 95% CI=0.877-1.180 for affective disorder; allelic P-value=0.476, genotypic P-value=0.469, OR=1.088, 95% CI=0.876-1.350 for MDD	No significant association was observed.	Negative