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Study Report
Comment on Study | View All Comments on Study |
Reference | Saus, E.,2010 PMID: 20618448 |
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Citation | Saus, E., V. Soria, et al. (2010). "A haplotype of glycogen synthase kinase 3beta is associated with early onset of unipolar major depression." Genes Brain Behav 9(7): 799-807. |
Disease Type | Bipolar Disorder & Major Depressive Disorder |
Study Design | case-control |
Study Type | Candidate-gene association study |
Sample Size | 445 unrelated patients(256 MDD patients and 189 BD patients) and 440 control subjects |
SNP/Region/Marker Size | 11 SNPs |
Predominant Ethnicity | |
Population | Spanish |
Gender | female: 47.5% for controls,67.2% for MDD patients and 64% for BD patients |
Age Group | Adults : Mean age(SD)(year):42.5(14.9) for controls,62.4(12.4),44.5 (14.7) at onset for MDD patients and 48.3(15.8),30.0 (12.7) at onset for BD patients |
Sample Diagnosis | DSM |
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Sample Status | The study sample consisted of 445 unrelated patients and 440 control subjects. Sample recruitment has been described previously (Soria et al . 2010). Briefly, patients with a major depressive episode of at least moderate severity were consecutively recruited between 2004 and 2007 from the outpatient (41.3%) and inpatient (58.7%) sections of Psychiatry Department at the 'Hospital Universitari de Bellvitge' (female: 65.8%; mean age at recruitment: 56.4 years, SD 15.6; mean AAO of illness: 38.6 years, SD 15.5). The patients were diagnosed by experienced psychiatrists using the Structured Clinical Interview (SCID) (First et al . 1997) according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (American Psychiatric Association 1994) for mood disorders (256 MDD, 189 BD). The baseline severity of the index depressive episode was assessed using the 21-item Hamilton Depression Rating Scale (HAM-D) (Hamilton 1960). The exclusion criteria were being under 18 years of age, presenting additional past or present psychiatric diagnoses other than MDD or BD, past or present history of psychoactive substance abuse except for nicotine and severe medical disease. Other sociodemographic and clinical variables such as AAO (defined as the age at which the patients first met DSM-IV criteria for either major depression or hypomania/mania), previous episodes and treatments were obtained by interviewing the patients and their nearest relatives in person and supported by available medical information. The control group consisted of 440 unrelated individuals (mean age: 42.5 years, SD 14.9) randomly selected from population registers in the same geographical area as the patients. Control subjects were screened for psychiatric diseases according to the 28- scaled Global Health Questionnaire (GHQ) (Lobo et al . 1986). Only unrelated subjects with no personal history of psychiatric disease, no clinically documented first-degree family history of psychiatric disease and a GHQ score <7 were included in the study. |
Technique | genotyping |
Statistical Method | Case-control association analyses to test for diagnosis phenotype (MDD and BD) were performed by logistic regression,while linear regression was used for quantitative traits (AAO and severity of depressive index episode). |
Result Summary | RESULTS: Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes. The differences in the frequencies of the TPH IVS7+218A alleles and genotypes approached statistical significance. CONCLUSIONS: The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs11925868 | GSK3B | C/A | association analyses with diagnosis: codominant P-value = 0.069, dominant P-value = 0.063, recessive P-value = 0.405, additive P-value = 0.168 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs11921360 | GSK3B | A/C | association analyses with diagnosis: codominant P-value = 0.696, dominant P-value = 0.56, recessive P-value = 0.687, additive P-value = 0.823 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs13314595 | GSK3B | C/T | association analyses with diagnosis: codominant P-value = 0.274, dominant P-value = 0.578, recessive P-value = 0.198, additive P-value = 0.971 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs11927974 | GSK3B | G/A | association analyses with diagnosis: codominant P-value = 0.437, dominant P-value = 0.81, recessive P-value = 0.234, additive P-value = 0.962 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs1054190 | GSK3B NR1I2 | C/T | association analyses with diagnosis: codominant P-value = 0.993, dominant P-value = 0.997, recessive P-value = 0.907, additive P-value = 0.973 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs9826659 | GSK3B | A/G | association analyses with diagnosis: codominant P-value = 0.868, dominant P-value = 0.715, recessive P-value = 0.631, additive P-value = 0.623 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs7431209 | GSK3B | G/A | association analyses with diagnosis: codominant P-value = 0.526, dominant P-value = 0.768, recessive P-value = 0.326, additive P-value = 0.87 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs334555 | GSK3B | C/G | association analyses with diagnosis: codominant P-value = 0.446, dominant P-value = 0.204, recessive P-value = 0.714, additive P-value = 0.223 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs334538 | RN7SL762P GSK3B | G/A | association analyses with diagnosis: codominant P-value = 0.587, dominant P-value = 0.5, recessive P-value = 0.35, additive P-value = 0.369 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs6438552 | GSK3B | A/G | association analyses with diagnosis: codominant P-value = 0.339, dominant P-value = 0.219, recessive P-value = 0.702, additive P-value = 0.517 | No significant association was observed in BD. No significant association was observed in BD. | Negative | |
rs3732360 | GSK3B NR1I2 | T/C | association analyses with diagnosis: codominant P-value = 0.437, dominant P-value = 0.568, recessive P-value = 0.205, additive P-value = 0.336 | No significant association was observed in BD. No significant association was observed in BD. | Negative |
Gene | Statistical Values/Author Comments | Result Category |
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GSK3B | We could not find evidence for association to either MDD or BP, thus not replicating previous positi...... We could not find evidence for association to either MDD or BP, thus not replicating previous positive results from others with respect to BD diagnosis. More... | Negative |
Disease | SNP | Related Gene(s) | Statistical Values | Description | Result Category |
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MDD | rs11921360 | GSK3B | association analyses with diagnosis:codominant P-value = 0.097, dominant P-value = 0.038, recessive P-value = 0.223, additive P-value = 0.033, all P-value > 0.05 after multiple testing correction. | No significant association was observed. | Negative |
MDD | rs1054190 | GSK3B NR1I2 | association analyses with diagnosis:codominant P-value = 0.521, dominant P-value = 0.393, recessive P-value = 0.547, additive P-value = 0.506 | No significant association was observed. | Negative |
MDD | rs9826659 | GSK3B | association analyses with diagnosis:codominant P-value = 0.377, dominant P-value = 0.373, recessive P-value = 0.427, additive P-value = 0.693 | No significant association was observed. | Negative |
MDD | rs334555 | GSK3B | association analyses with diagnosis:codominant P-value = 0.793, dominant P-value = 0.556, recessive P-value = 0.632, additive P-value = 0.506 | No significant association was observed. | Negative |
MDD | rs3732360 | GSK3B NR1I2 | association analyses with diagnosis:codominant P-value = 0.515, dominant P-value = 0.25, recessive P-value = 0.765, additive P-value = 0.302 | No significant association was observed. | Negative |
MDD | rs6438552 | GSK3B | association analyses with diagnosis:codominant P-value = 0.228, dominant P-value = 0.277, recessive P-value = 0.109, additive P-value = 0.102 | No significant association was observed. | Negative |
MDD | rs7431209 | GSK3B | association analyses with diagnosis:codominant P-value = 0.076, dominant P-value = 0.048, recessive P-value = 0.594, additive P-value = 0.159, all P-value > 0.05 after multiple testing correction. | No significant association was observed. | Negative |
MDD | rs11925868 | GSK3B | association analyses with diagnosis:codominant P-value = 0.811, dominant P-value = 0.572, recessive P-value = 0.845, additive P-value = 0.641 | No significant association was observed. | Negative |
MDD | rs11927974 | GSK3B | association analyses with diagnosis:codominant P-value = 0.389, dominant P-value = 0.975, recessive P-value = 0.172, additive P-value = 0.909 | No significant association was observed. | Negative |
MDD | rs13314595 | GSK3B | association analyses with diagnosis:codominant P-value = 0.899, dominant P-value = 0.923, recessive P-value = 0.68, additive P-value = 0.947 | No significant association was observed. | Negative |
MDD | rs334538 | RN7SL762P GSK3B | association analyses with diagnosis:codominant P-value = 0.992, dominant P-value = 0.907, recessive P-value = 0.946, additive P-value = 0.902 | No significant association was observed. | Negative |
Disease | Gene | Description | Result Category |
---|---|---|---|
MDD | GSK3B | We could not find evidence for association to either MDD or BP. | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016