BDgene

Study Report

Basic Info
Reference
Citation Saus, E., V. Soria, et al. (2010). "A haplotype of glycogen synthase kinase 3beta is associated with early onset of unipolar major depression." Genes Brain Behav 9(7): 799-807.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 445 unrelated patients(256 MDD patients and 189 BD patients) and 440 control subjects
SNP/Region/Marker Size 11 SNPs
Predominant Ethnicity
Population Spanish
Gender female: 47.5% for controls,67.2% for MDD patients and 64% for BD patients
Age Group Adults : Mean age(SD)(year):42.5(14.9) for controls,62.4(12.4),44.5 (14.7) at onset for MDD patients and 48.3(15.8),30.0 (12.7) at onset for BD patients

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 11)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
MDD rs11921360 GSK3B association analyses with diagnosis:codominant P-value = 0.097, dominant P-value = 0.038, recessive P-value = 0.223, additive P-value = 0.033, all P-value > 0.05 after multiple testing correction. No significant association was observed. Negative
MDD rs1054190 GSK3B NR1I2 association analyses with diagnosis:codominant P-value = 0.521, dominant P-value = 0.393, recessive P-value = 0.547, additive P-value = 0.506 No significant association was observed. Negative
MDD rs9826659 GSK3B association analyses with diagnosis:codominant P-value = 0.377, dominant P-value = 0.373, recessive P-value = 0.427, additive P-value = 0.693 No significant association was observed. Negative
MDD rs334555 GSK3B association analyses with diagnosis:codominant P-value = 0.793, dominant P-value = 0.556, recessive P-value = 0.632, additive P-value = 0.506 No significant association was observed. Negative
MDD rs3732360 GSK3B NR1I2 association analyses with diagnosis:codominant P-value = 0.515, dominant P-value = 0.25, recessive P-value = 0.765, additive P-value = 0.302 No significant association was observed. Negative
MDD rs6438552 GSK3B association analyses with diagnosis:codominant P-value = 0.228, dominant P-value = 0.277, recessive P-value = 0.109, additive P-value = 0.102 No significant association was observed. Negative
MDD rs7431209 GSK3B association analyses with diagnosis:codominant P-value = 0.076, dominant P-value = 0.048, recessive P-value = 0.594, additive P-value = 0.159, all P-value > 0.05 after multiple testing correction. No significant association was observed. Negative
MDD rs11925868 GSK3B association analyses with diagnosis:codominant P-value = 0.811, dominant P-value = 0.572, recessive P-value = 0.845, additive P-value = 0.641 No significant association was observed. Negative
MDD rs11927974 GSK3B association analyses with diagnosis:codominant P-value = 0.389, dominant P-value = 0.975, recessive P-value = 0.172, additive P-value = 0.909 No significant association was observed. Negative
MDD rs13314595 GSK3B association analyses with diagnosis:codominant P-value = 0.899, dominant P-value = 0.923, recessive P-value = 0.68, additive P-value = 0.947 No significant association was observed. Negative
MDD rs334538 RN7SL762P GSK3B association analyses with diagnosis:codominant P-value = 0.992, dominant P-value = 0.907, recessive P-value = 0.946, additive P-value = 0.902 No significant association was observed. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD GSK3B We could not find evidence for association to either MDD or BP. Negative