SNP Report

Basic Info

Name	rs33388 dbSNP Ensembl
Location	chr5:143317730 - 143317730(1)
Variant Alleles	A/T
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.393371
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000231509, ENST00000343796, ENST00000394464, ENST00000394466, ENST00000415690, ENST00000424646, ENST00000503201, ENST00000504336, ENST00000504572); non_coding_transcript_variant(ENST00000504336)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Szczepankiewicz, A.,2011	A/T	For BD, X² test: allele, P-value > 0.05; the Fish...... For BD, X² test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.050 More...	No significant association was observed in BD. No significant association was observed in BD.	Negative
Leszczynska-Rodziewicz, A., 2012	A/T	genotypic P-value = 0.15 genotypic P-value = 0.15	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative
Leszczynska-Rodziewicz A, 2013	A/T	P-value=0.23 P-value=0.23	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	5q31-q32	5(2/3/0)

SNPs in LD with rs33388 (count: 8) View in gBrowse (chr5:143246695..143401132 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs258747	downstream_gene_variant	0.96[CEU]; 0.953[TSI]
rs852980	intron_variant; non_coding_transcript_variant	0.96[CEU]
rs853175		0.922[CEU]
rs864354		0.922[CEU]; 0.977[TSI]
rs11750560		0.881[CEU]; 0.841[TSI]
rs4634384	intron_variant; upstream_gene_variant	0.953[CEU]
rs33383	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.954[TSI]
rs258763		0.88[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A.,2011	X² test:allele, P-value = 0.018, OR=0.759, 95% CI=0.605-0.953;the Fisher exact test:genotype, P-value > 0.05	Significant association was found.	Positive