Study Report

Basic Info

Reference	Mann, J. J., 2008 PMID: 17604842
Citation	Mann, J. J., D. Currier, et al. (2008). "No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover." J Affect Disord 106(1-2): 117-121.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	109 BD, 324 MDD and 130 controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity	Caucasian and Mongloid

Detail Info

Sample Diagnosis	DSM-IV
Technique	PCR; high-performance liquid chromatography (HPLC) with electrochemical detection
Statistical Method	Genotype and allelic distributions were compared groups using the Chi2 contingency table test. One-way analysis of variance was used to compare psychopathology rating scales, and CSF 5-HIAA, HVA, and MHPG levels by genotype. General linear models (GLMs) and logistic regression were used in exploratory analyses.
Result Summary	There was no association between genotype and either mood disorder, suicide attempt status, psychopathology severity or CSF monoamine metabolite levels.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs4131347	TBC1D15 TPH2	G/C		Genotypic P-value = 0.388, allelic P-value = 0.863 for BD when compared with controls.	There were no differences between BD and healthy volunteers ...... There were no differences between BD and healthy volunteers in genotype or allelic frequency. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
TPH2	No association was detected between the rs4131347 (?C8347G) SNP in the promoter region of the TPH2 g...... No association was detected between the rs4131347 (?C8347G) SNP in the promoter region of the TPH2 gene and mood disorders More...	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
MDD	rs4131347	TBC1D15 TPH2	Genotypic P-value = 0.684, allelic P-value = 0.502 for MDD when compared with controls.	There were no differences between MDD and healthy volunteers in genotype or allelic frequency.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	TPH2	No association was detected between the rs4131347 (?C8347G) SNP in the promoter region of the TPH2 gene and mood disorders	Negative