SNP Report

Basic Info

Name	rs6191 dbSNP Ensembl
Location	chr5:143278591 - 143278591(1)
Variant Alleles	C/A
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.401558
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000343796, ENST00000394464, ENST00000415690); downstream_gene_variant(ENST00000231509, ENST00000394466, ENST00000424646, ENST00000503201, ENST00000504572)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Leszczynska-Rodziewicz, A., 2012	A/C	genotypic P-value = 0.16 genotypic P-value = 0.16	There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More...	Negative
Szczepankiewicz, A.,2011	A/C	For BD, X² test: allele, P-value > 0.05; the Fish...... For BD, X² test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.029 More...	No significant association was observed in BD. No significant association was observed in BD.	Negative
Leszczynska-Rodziewicz A, 2013	A/C	P-value=0.26 P-value=0.26	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	5q31-q32	5(2/3/0)

SNPs in LD with rs6191 (count: 0) View in gBrowse (chr5:143278591..143278591 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz, A.,2011	X² test:allele, P-value = 0.015 for alleles, OR=1.338, 95% CI: 1.059-1.689;the Fisher exact test:genotype, P-value = 0.049	Significant association was found.	Positive