BDgene

SNP Report

Basic Info
Name rs10052957 dbSNP Ensembl
Location chr5:143407136 - 143407136(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele A
Minor Allele Frequence 0.221246
Functional Annotation downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000503701, ENST00000505058); intron_variant(ENST00000343796, ENST00000504572); non_coding_transcript_exon_variant(ENST00000623204); non_coding_transcript_variant(ENST00000623204); upstream_gene_variant(ENST00000231509, ENST00000394464, ENST00000394466, ENST00000415690, ENST00000502892, ENST00000503201, ENST00000508760, ENST00000510170, ENST00000514699)
No. of Studies 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Leszczynska-Rodziewicz, A., 2012 A/G genotypic P-value = 0.62 genotypic P-value = 0.62 There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More... Negative
Szczepankiewicz, A.,2011 A/G For BD, X2 test: allele, P-value > 0.05; the Fish...... For BD, X2 test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.122 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Leszczynska-Rodziewicz A, 2013 A/G P-value=0.22 P-value=0.22 Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More... Negative
Spijker, A. T.,2009 C/T Genotypic association: P-value = 0.03; odds ratio (OR) = 0....... Genotypic association: P-value = 0.03; odds ratio (OR) = 0.51, 95% confidence interval (CI): 0.27-0.95 More... In subjects of the patient group, a significantly lower freq...... In subjects of the patient group, a significantly lower frequency of heterozygous TthIIII carriers compared to the control group was found More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0)

SNPs in LD with rs10052957 (count: 12) View in gBrowse (chr5:143242611..143407136 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 12)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Szczepankiewicz, A.,2011 X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 No significant association was observed. Negative