BDgene

SNP Report

Basic Info
Name rs110402 dbSNP Ensembl
Location chrCHR_HSCHR17_2_CTG5:45814295 - 45814295(1)
Variant Alleles G/A
Ancestral Allele G
Minor Allele G
Minor Allele Frequence 0.438898
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000293493, ENST00000314537, ENST00000339069, ENST00000347197, ENST00000352855, ENST00000398285, ENST00000577353, ENST00000582766, ENST00000587305, ENST00000619154, ENST00000634540, ENST00000634876); NMD_transcript_variant(ENST00000347197); non_coding_transcript_variant(ENST00000582766, ENST00000587305, ENST00000634876); upstream_gene_variant(ENST00000580955, ENST00000611599, ENST00000613260, ENST00000614143, ENST00000615345, ENST00000617446, ENST00000618382, ENST00000616225, ENST00000616274, ENST00000616748, ENST00000617905, ENST00000618144, ENST00000621969, ENST00000631500, ENST00000632383, ENST00000632599, ENST00000633723, ENST00000634181, ENST00000632383, ENST00000631500, ENST00000632599, ENST00000634181, ENST00000632552)
No. of Studies 4 (Positive: 0; Negative: 4; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Ceulemans, S.,2011 C/T Single SNP analyses: Permuted P-value = 0.7493, Odds Ratio=0...... Single SNP analyses: Permuted P-value = 0.7493, Odds Ratio=0.9655 More... No significant association was observed. No significant association was observed. Negative
Leszczynska-Rodziewicz, A., 2012 A/G genotypic P-value = 0.06 genotypic P-value = 0.06 There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More... Negative
Szczepankiewicz, A., 2013 A/G allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 95...... allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 95% CI=0.755-1.013 for affective disorder; allelic P-value=0.16, genotypic P-value=0.343, OR=0.885, 95% CI=0.751-1.041 for BD More... No significant association was observed. No significant association was observed. Negative
Leszczynska-Rodziewicz A, 2013 A/G P-value=0.10 P-value=0.10 Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More... Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MAPT-AS1 MAPT antisense RNA 1 17q21.31 Mapped by Literature SNP
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 4(2/2/0)

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 7)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Szczepankiewicz, A., 2013 allelic P-value=0.079, genotypic P-value=0.166, OR=0.874, 95% CI=0.755-1.013 for affective disorder; allelic P-value=0.144, genotypic P-value=0.238, OR=0.852, 95% CI=0.689-1.054 for MDD No significant association was observed. Negative