BDgene

SNP Report

Basic Info
Name rs6196 dbSNP Ensembl
Location chr5:143281925 - 143281925(1)
Variant Alleles A/G
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.11881
Functional Annotation intron_variant; synonymous_variant.
Consequence to Transcript intron_variant(ENST00000415690); synonymous_variant(ENST00000231509, ENST00000343796, ENST00000394464, ENST00000394466, ENST00000424646, ENST00000503201, ENST00000504572)
No. of Studies 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Leszczynska-Rodziewicz, A., 2012 A/G genotypic P-value = 0.14 genotypic P-value = 0.14 There were no significant differences for other polymorphism...... There were no significant differences for other polymorphisms in the studied group in comparison to the control group. More... Negative
Szczepankiewicz, A.,2011 A/G For BD, X2 test: allele, P-value > 0.05; the Fish...... For BD, X2 test: allele, P-value > 0.05; the Fisher exact test: genotype, P-value > 0.05; for the course of bipolar disorder: genotype P-value = 0.138 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Leszczynska-Rodziewicz A, 2013 A/G P-value=0.27 P-value=0.27 Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More... Negative
Ceulemans, S.,2011 G/A Single SNP analyses: Permuted P-value = 0.02939, Odds Ratio=...... Single SNP analyses: Permuted P-value = 0.02939, Odds Ratio=0.7022 More... Significant associations were found . Significant associations were found . Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0)

SNPs in LD with rs6196 (count: 14) View in gBrowse (chr5:143246483..143376701 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 14)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Szczepankiewicz, A.,2011 X2 test:allele, P-value > 0.05;the Fisher exact test:genotype, P-value > 0.05 No significant association was observed. Negative